Flecked retina secondary to oxalate crystals from methoxyflurane anesthesia: clinical and experimental studies

D. M. Albert, J. D. Bullock, M. Lahav, R. Caine

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Recently we encountered a patient with an ophthalmoscopic appearance suggestive of a flecked retina syndrome. Crystalline deposits of calcium oxalate were observed in the retinal pigment epithelium (RPE) and appeared to account for the flecks that were seen ophthalmoscopically. It was found from the past history that this patient had undergone prolonged general anesthesia with methoxyflurane, an anesthetic agent which undergoes degradation in the liver to oxalate and fluoride ions. A second patient with a similar appearance was subsequently observed and is described here. To test the hypothesis that prolonged hyperoxalemia may be a cause of flecked retina, we have attempted to experimentally reproduce this disease in animals. The results of a rabbit model for retinal oxalosis resembling the clinical appearance of the flecked retina are described.

Original languageEnglish (US)
Pages (from-to)OP-817-826
JournalTransactions of the American Academy of Ophthalmology and Otolaryngology
Issue number6
StatePublished - Dec 1 1975


ASJC Scopus subject areas

  • Medicine(all)

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