Fish oils in hypertriglyceridemia: A dose-response study

W. S. Harris, D. W. Rothrock, A. Fanning, S. B. Inkeles, S. H. Goodnight, D. R. Illingworth, W. E. Connor

Research output: Contribution to journalArticlepeer-review

69 Scopus citations


The effects of three supplemental doses of fish oil on plasma lipids, lipoproteins, and bleeding times were studied in ten hypertriglyceridemia patients. After a 3-wk baseline period each patient was given 15, 25, or 40 mL fish oil/d (containing 4.5, 7.5, and 12 g n-3 fatty acids) for three successive 6-wk periods, each separated by a 4-wk period of no supplementation. Plasma cholesterol concentrations decreased from 7.40 mmol/L to 6.35, 6.55, and 6.40 mmol/L with increasing doses of fish oil (p<0.01 vs baseline for each). Plasma triglyceride concentrations decreased from 6.10 mmol/L to 2.90, 2.80, and 2.35 mmol/L (p<0.01 vs baseline for each). Low-density-lipoprotein cholesterol concentrations increased significantly (by 23% and 28%) with the two higher doses, respectively. Bleeding times increased only with the largest dose. The lowest dose was the most hypolipidemic per gram n-3 fatty acids.

Original languageEnglish (US)
Pages (from-to)399-406
Number of pages8
JournalAmerican Journal of Clinical Nutrition
Issue number3
StatePublished - 1990
Externally publishedYes


  • dietary fats
  • fish oils
  • hypercholesterolemia
  • hypertriglyceridemia
  • lipoproteins
  • plasma lipids
  • platelets
  • unsaturated fatty acids

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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