Fish oils in hypertriglyceridemia

A dose-response study

William Harris, Douglas W. Rothrock, Ann Fanning, Stephen B. Inkeles, Scott H. Goodnight, D. Roger Illingworth, William E. Connor

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

The effects of three supplemental doses of fish oil on plasma lipids, lipoproteins, and bleeding times were studied in ten hypertriglyceridemic patients. After a 3-wk base-line period each patient was given 15, 25, or 40 mL fish oil/d (containing 4.5, 7.5, and 12 g n-3 fatty acids) for three successive 6-wk periods, each separated by a 4-wk period of no supplementation. Plasma cholesterol concentrations decreased from 7.40 mmol/L to 6.35, 6.55, and 6.40 mmol/L with increasing doses of fish oil (p <0.01 vs baseline for each). Plasma triglyceride concentrations decreased from 6.10 mmol/L to 2.90, 2.80, and 2.35 mmol/L (p <0.01 vs baseline for each). Low-density-lipoprotein cholesterol concentrations increased significantly (by 23% and 28%) with the two higher doses, respectively. Bleeding times increased only with the largest dose. The lowest dose was the most hypolipidemic per gram n-3 fatty acids.

Original languageEnglish (US)
Pages (from-to)399-406
Number of pages8
JournalAmerican Journal of Clinical Nutrition
Volume51
Issue number3
StatePublished - Mar 1990
Externally publishedYes

Fingerprint

hypertriglyceridemia
Fish Oils
Hypertriglyceridemia
fish oils
dose response
Bleeding Time
Omega-3 Fatty Acids
dosage
omega-3 fatty acids
hemorrhage
LDL Cholesterol
Lipoproteins
Triglycerides
Cholesterol
Lipids
low density lipoprotein cholesterol
lipoproteins
blood lipids
triacylglycerols
cholesterol

Keywords

  • Dietary fats
  • Fish oils
  • Hypercholesterolemia
  • Hypertriglyceridemia
  • Lipoproteins
  • Plasma lipids
  • Platelets
  • Unsaturated fatty acids

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Harris, W., Rothrock, D. W., Fanning, A., Inkeles, S. B., Goodnight, S. H., Illingworth, D. R., & Connor, W. E. (1990). Fish oils in hypertriglyceridemia: A dose-response study. American Journal of Clinical Nutrition, 51(3), 399-406.

Fish oils in hypertriglyceridemia : A dose-response study. / Harris, William; Rothrock, Douglas W.; Fanning, Ann; Inkeles, Stephen B.; Goodnight, Scott H.; Illingworth, D. Roger; Connor, William E.

In: American Journal of Clinical Nutrition, Vol. 51, No. 3, 03.1990, p. 399-406.

Research output: Contribution to journalArticle

Harris, W, Rothrock, DW, Fanning, A, Inkeles, SB, Goodnight, SH, Illingworth, DR & Connor, WE 1990, 'Fish oils in hypertriglyceridemia: A dose-response study', American Journal of Clinical Nutrition, vol. 51, no. 3, pp. 399-406.
Harris W, Rothrock DW, Fanning A, Inkeles SB, Goodnight SH, Illingworth DR et al. Fish oils in hypertriglyceridemia: A dose-response study. American Journal of Clinical Nutrition. 1990 Mar;51(3):399-406.
Harris, William ; Rothrock, Douglas W. ; Fanning, Ann ; Inkeles, Stephen B. ; Goodnight, Scott H. ; Illingworth, D. Roger ; Connor, William E. / Fish oils in hypertriglyceridemia : A dose-response study. In: American Journal of Clinical Nutrition. 1990 ; Vol. 51, No. 3. pp. 399-406.
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