Fish oils in hypertriglyceridemia: A dose-response study

W. S. Harris, D. W. Rothrock, A. Fanning, S. B. Inkeles, S. H. Goodnight, D. R. Illingworth, W. E. Connor

Research output: Contribution to journalArticle

64 Scopus citations

Abstract

The effects of three supplemental doses of fish oil on plasma lipids, lipoproteins, and bleeding times were studied in ten hypertriglyceridemia patients. After a 3-wk baseline period each patient was given 15, 25, or 40 mL fish oil/d (containing 4.5, 7.5, and 12 g n-3 fatty acids) for three successive 6-wk periods, each separated by a 4-wk period of no supplementation. Plasma cholesterol concentrations decreased from 7.40 mmol/L to 6.35, 6.55, and 6.40 mmol/L with increasing doses of fish oil (p<0.01 vs baseline for each). Plasma triglyceride concentrations decreased from 6.10 mmol/L to 2.90, 2.80, and 2.35 mmol/L (p<0.01 vs baseline for each). Low-density-lipoprotein cholesterol concentrations increased significantly (by 23% and 28%) with the two higher doses, respectively. Bleeding times increased only with the largest dose. The lowest dose was the most hypolipidemic per gram n-3 fatty acids.

Original languageEnglish (US)
Pages (from-to)399-406
Number of pages8
JournalAmerican Journal of Clinical Nutrition
Volume51
Issue number3
DOIs
StatePublished - 1990

Keywords

  • dietary fats
  • fish oils
  • hypercholesterolemia
  • hypertriglyceridemia
  • lipoproteins
  • plasma lipids
  • platelets
  • unsaturated fatty acids

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Fingerprint Dive into the research topics of 'Fish oils in hypertriglyceridemia: A dose-response study'. Together they form a unique fingerprint.

  • Cite this

    Harris, W. S., Rothrock, D. W., Fanning, A., Inkeles, S. B., Goodnight, S. H., Illingworth, D. R., & Connor, W. E. (1990). Fish oils in hypertriglyceridemia: A dose-response study. American Journal of Clinical Nutrition, 51(3), 399-406. https://doi.org/10.1093/ajcn/51.3.399