First example of a molecularly imprinted polymer incorporating a difunctionalized alloxazine flavin isomer

Andrew J. Robak; Bruce P. Branchaud

doi:10.1016/j.tetlet.2005.06.102

First example of a molecularly imprinted polymer incorporating a difunctionalized alloxazine flavin isomer

Andrew J. Robak, Bruce P. Branchaud

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

High-quality alloxazine (a flavin isomer) imprinted polymers have been made for the first time. A molecularly imprinted polymer (MIP) for the N1,N3-di-functionalized alloxazine template 2 was made. The MIP prepared for 2 exhibited excellent, highly selective molecular recognition for template 2, as determined by HPLC analysis using columns prepared with the MIP. This has also demonstrated that the core flavin structure can survive the imprinting process.

Original language	English (US)
Pages (from-to)	5651-5654
Number of pages	4
Journal	Tetrahedron Letters
Volume	46
Issue number	34
DOIs	https://doi.org/10.1016/j.tetlet.2005.06.102
State	Published - Aug 22 2005
Externally published	Yes

Keywords

Alloxazine
Enzyme mimetic
Flavin
Molecularly imprinted polymer
Redox catalyst

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2005.06.102

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title = "First example of a molecularly imprinted polymer incorporating a difunctionalized alloxazine flavin isomer",

abstract = "High-quality alloxazine (a flavin isomer) imprinted polymers have been made for the first time. A molecularly imprinted polymer (MIP) for the N1,N3-di-functionalized alloxazine template 2 was made. The MIP prepared for 2 exhibited excellent, highly selective molecular recognition for template 2, as determined by HPLC analysis using columns prepared with the MIP. This has also demonstrated that the core flavin structure can survive the imprinting process.",

keywords = "Alloxazine, Enzyme mimetic, Flavin, Molecularly imprinted polymer, Redox catalyst",

author = "Robak, {Andrew J.} and Branchaud, {Bruce P.}",

note = "Funding Information: This research has been supported by the University of Oregon Department of Chemistry and Materials Science Institute. ",

year = "2005",

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doi = "10.1016/j.tetlet.2005.06.102",

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T1 - First example of a molecularly imprinted polymer incorporating a difunctionalized alloxazine flavin isomer

AU - Robak, Andrew J.

AU - Branchaud, Bruce P.

N1 - Funding Information: This research has been supported by the University of Oregon Department of Chemistry and Materials Science Institute.

PY - 2005/8/22

Y1 - 2005/8/22

N2 - High-quality alloxazine (a flavin isomer) imprinted polymers have been made for the first time. A molecularly imprinted polymer (MIP) for the N1,N3-di-functionalized alloxazine template 2 was made. The MIP prepared for 2 exhibited excellent, highly selective molecular recognition for template 2, as determined by HPLC analysis using columns prepared with the MIP. This has also demonstrated that the core flavin structure can survive the imprinting process.

AB - High-quality alloxazine (a flavin isomer) imprinted polymers have been made for the first time. A molecularly imprinted polymer (MIP) for the N1,N3-di-functionalized alloxazine template 2 was made. The MIP prepared for 2 exhibited excellent, highly selective molecular recognition for template 2, as determined by HPLC analysis using columns prepared with the MIP. This has also demonstrated that the core flavin structure can survive the imprinting process.

KW - Alloxazine

KW - Enzyme mimetic

KW - Flavin

KW - Molecularly imprinted polymer

KW - Redox catalyst

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M3 - Article

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SN - 0040-4039

VL - 46

SP - 5651

EP - 5654

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 34

ER -

First example of a molecularly imprinted polymer incorporating a difunctionalized alloxazine flavin isomer

Abstract

Keywords

ASJC Scopus subject areas

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