First example of a molecularly imprinted polymer incorporating a difunctionalized alloxazine flavin isomer

Andrew J. Robak, Bruce P. Branchaud

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

High-quality alloxazine (a flavin isomer) imprinted polymers have been made for the first time. A molecularly imprinted polymer (MIP) for the N1,N3-di-functionalized alloxazine template 2 was made. The MIP prepared for 2 exhibited excellent, highly selective molecular recognition for template 2, as determined by HPLC analysis using columns prepared with the MIP. This has also demonstrated that the core flavin structure can survive the imprinting process.

Original languageEnglish (US)
Pages (from-to)5651-5654
Number of pages4
JournalTetrahedron Letters
Volume46
Issue number34
DOIs
StatePublished - Aug 22 2005

Keywords

  • Alloxazine
  • Enzyme mimetic
  • Flavin
  • Molecularly imprinted polymer
  • Redox catalyst

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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