Filtering of acoustic signals within the hearing organ

Sripriya Ramamoorthy, Dingjun Zha, Fangyi Chen, Steven Jacques, Ruikang Wang, Niloy Choudhury, Alfred Nuttall, Anders Fridberger

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The detection of sound by the mammalian hearing organ involves a complex mechanical interplay among different cell types. The inner hair cells, which are the primary sensory receptors, are stimulated by the structural vibrations of the entire organ of Corti. The outer hair cells are thought to modulate these sound-evoked vibrations to enhance hearing sensitivity and frequency resolution, but it remains unclear whether other structures also contribute to frequency tuning. In the current study, sound-evoked vibrations were measured at the stereociliary side of inner and outer hair cells and their surrounding supporting cells, using optical coherence tomography interferometry in living anesthetized guinea pigs. Our measurements demonstrate the presence of multiple vibration modes as well as significant differences in frequency tuning and response phase among different cell types. In particular, the frequency tuning at the inner hair cells differs from other cell types, causing the locus of maximum inner hair cell activation to be shifted toward the apex of the cochlea compared with the outer hair cells. These observations show that additional processing and filtering of acoustic signals occur within the organ of Corti before inner hair cell excitation, representing a departure from established theories.

Original languageEnglish (US)
Pages (from-to)9051-9058
Number of pages8
JournalJournal of Neuroscience
Volume34
Issue number27
DOIs
StatePublished - 2014

Fingerprint

Inner Auditory Hair Cells
Outer Auditory Hair Cells
Acoustics
Hearing
Vibration
Organ of Corti
Interferometry
Cochlea
Optical Coherence Tomography
Sensory Receptor Cells
Guinea Pigs

Keywords

  • Basilar membrane
  • Cochlea
  • Cochlear amplifier
  • Inner hair cells
  • Outer hair cells
  • Reticular lamina

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Ramamoorthy, S., Zha, D., Chen, F., Jacques, S., Wang, R., Choudhury, N., ... Fridberger, A. (2014). Filtering of acoustic signals within the hearing organ. Journal of Neuroscience, 34(27), 9051-9058. https://doi.org/10.1523/JNEUROSCI.0722-14.2014

Filtering of acoustic signals within the hearing organ. / Ramamoorthy, Sripriya; Zha, Dingjun; Chen, Fangyi; Jacques, Steven; Wang, Ruikang; Choudhury, Niloy; Nuttall, Alfred; Fridberger, Anders.

In: Journal of Neuroscience, Vol. 34, No. 27, 2014, p. 9051-9058.

Research output: Contribution to journalArticle

Ramamoorthy, S, Zha, D, Chen, F, Jacques, S, Wang, R, Choudhury, N, Nuttall, A & Fridberger, A 2014, 'Filtering of acoustic signals within the hearing organ', Journal of Neuroscience, vol. 34, no. 27, pp. 9051-9058. https://doi.org/10.1523/JNEUROSCI.0722-14.2014
Ramamoorthy S, Zha D, Chen F, Jacques S, Wang R, Choudhury N et al. Filtering of acoustic signals within the hearing organ. Journal of Neuroscience. 2014;34(27):9051-9058. https://doi.org/10.1523/JNEUROSCI.0722-14.2014
Ramamoorthy, Sripriya ; Zha, Dingjun ; Chen, Fangyi ; Jacques, Steven ; Wang, Ruikang ; Choudhury, Niloy ; Nuttall, Alfred ; Fridberger, Anders. / Filtering of acoustic signals within the hearing organ. In: Journal of Neuroscience. 2014 ; Vol. 34, No. 27. pp. 9051-9058.
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