Fibrillin-2 is dispensable for peripheral nerve development, myelination and regeneration

Michael A. Chernousov, Kelly Baylor, Richard C. Stahl, Mark M. Stecker, Lynn Sakai, Sui Lee-Arteaga, Francesco Ramirez, David J. Carey

Research output: Contribution to journalArticle

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Abstract

The extracellular matrix of peripheral nerve is formed from a diverse set of macromolecules, including glycoproteins, collagens and proteoglycans. Recent studies using knockout animal models have demonstrated that individual components of the extracellular matrix play a vital role in peripheral nerve development and regeneration. In this study we identified fibrillin-1 and fibrillin-2, large modular structural glycoproteins, as components of the extracellular matrix of peripheral nerve. Previously it was found that fibrillin-2 null mice display joint contractures, suggesting a possible defect of the peripheral nervous system in these animals. Close examination of the peripheral nerves of fibrillin-2 deficient animals described here revealed some structural abnormalities in the perineurium, while general structure of the nerve and molecular composition of nerve extracellular matrix remained unchanged. We also found that in spite of the obvious motor function impairment, fibrillin-2 null mice failed to display changes of nerve conduction properties or nerve regeneration capacity. Based on the data obtained we can conclude that peripheral neuropathy should be excluded as the cause of the impairment of locomotory function and joint contractures observed in fibrillin-2 deficient animals.

Original languageEnglish (US)
Pages (from-to)357-368
Number of pages12
JournalMatrix Biology
Volume29
Issue number5
DOIs
StatePublished - Jun 1 2010

Fingerprint

Peripheral Nerves
Regeneration
Extracellular Matrix
Nerve Regeneration
Contracture
Joints
Neural Conduction
Peripheral Nervous System
Peripheral Nervous System Diseases
Proteoglycans
Molecular Structure
Glycoproteins
Collagen
Animal Models
Fibrillin-2

Keywords

  • Extracellular matrix
  • Fibrillin
  • Peripheral nerve

ASJC Scopus subject areas

  • Molecular Biology

Cite this

Chernousov, M. A., Baylor, K., Stahl, R. C., Stecker, M. M., Sakai, L., Lee-Arteaga, S., ... Carey, D. J. (2010). Fibrillin-2 is dispensable for peripheral nerve development, myelination and regeneration. Matrix Biology, 29(5), 357-368. https://doi.org/10.1016/j.matbio.2010.02.006

Fibrillin-2 is dispensable for peripheral nerve development, myelination and regeneration. / Chernousov, Michael A.; Baylor, Kelly; Stahl, Richard C.; Stecker, Mark M.; Sakai, Lynn; Lee-Arteaga, Sui; Ramirez, Francesco; Carey, David J.

In: Matrix Biology, Vol. 29, No. 5, 01.06.2010, p. 357-368.

Research output: Contribution to journalArticle

Chernousov, MA, Baylor, K, Stahl, RC, Stecker, MM, Sakai, L, Lee-Arteaga, S, Ramirez, F & Carey, DJ 2010, 'Fibrillin-2 is dispensable for peripheral nerve development, myelination and regeneration', Matrix Biology, vol. 29, no. 5, pp. 357-368. https://doi.org/10.1016/j.matbio.2010.02.006
Chernousov, Michael A. ; Baylor, Kelly ; Stahl, Richard C. ; Stecker, Mark M. ; Sakai, Lynn ; Lee-Arteaga, Sui ; Ramirez, Francesco ; Carey, David J. / Fibrillin-2 is dispensable for peripheral nerve development, myelination and regeneration. In: Matrix Biology. 2010 ; Vol. 29, No. 5. pp. 357-368.
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