Fetal oxygenation and Doppler ultrasonography of cardiovascular hemodynamics in a chronic near-term sheep model

Kaarin Mäkikallio, Tiina Erkinaro, Niina Niemi, Tomi Kavasmaa, Ganesh Acharya, Mervi Päkkilä, Juha Rasanen

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Objective: We hypothesized that a decrease in fetal oxygenation without acidemia in a near-term fetal sheep leads to cardiovascular hemodynamic changes that are detectable by Doppler ultrasonography. Study design: Twelve ewes and fetuses were instrumented at 112 to 127 days of gestation. After a 5-day recovery period, experiments were performed with general anesthesia. Uterine and placental volume blood flows and fetal arterial and venous blood pressures were measured. Fetal cardiovascular hemodynamics was assessed by Doppler ultrasonography. All the measurements were performed at baseline, during fetal hypo-oxygenation, and at recovery phase. Results: A drop in fetal Po2 was related to increased (P <.05) weight-indexed right ventricular and combined cardiac outputs and proximal branch pulmonary artery pulsatility index values. The increase in proximal branch pulmonary artery pulsatility index values correlated (R = .59; P <.05) with the decrease in fetal oxygen saturation. In the aortic isthmus, the time-velocity integral ratio between antegrade and retrograde blood flow components decreased (P <.05) when fetal Po2 dropped. Conclusion: During decreased fetal oxygenation Doppler ultrasonography demonstrated increased fetal cardiac output and pulmonary arterial vascular impedance and a relative increase in the retrograde blood flow component in the aortic isthmus.

Original languageEnglish (US)
Pages (from-to)542-550
Number of pages9
JournalAmerican Journal of Obstetrics and Gynecology
Volume194
Issue number2
DOIs
StatePublished - Feb 2006
Externally publishedYes

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Prenatal Ultrasonography
Doppler Ultrasonography
Sheep
Hemodynamics
Cardiac Output
Pulmonary Artery
Venous Pressure
Blood Volume
Electric Impedance
Fetal Blood
General Anesthesia
Blood Vessels
Arterial Pressure
Fetus
Oxygen
Weights and Measures
Pregnancy
Lung

Keywords

  • Doppler ultrasonography
  • Fetal sheep
  • Oxygen
  • Physiology

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Fetal oxygenation and Doppler ultrasonography of cardiovascular hemodynamics in a chronic near-term sheep model. / Mäkikallio, Kaarin; Erkinaro, Tiina; Niemi, Niina; Kavasmaa, Tomi; Acharya, Ganesh; Päkkilä, Mervi; Rasanen, Juha.

In: American Journal of Obstetrics and Gynecology, Vol. 194, No. 2, 02.2006, p. 542-550.

Research output: Contribution to journalArticle

Mäkikallio, K, Erkinaro, T, Niemi, N, Kavasmaa, T, Acharya, G, Päkkilä, M & Rasanen, J 2006, 'Fetal oxygenation and Doppler ultrasonography of cardiovascular hemodynamics in a chronic near-term sheep model', American Journal of Obstetrics and Gynecology, vol. 194, no. 2, pp. 542-550. https://doi.org/10.1016/j.ajog.2005.08.028
Mäkikallio, Kaarin ; Erkinaro, Tiina ; Niemi, Niina ; Kavasmaa, Tomi ; Acharya, Ganesh ; Päkkilä, Mervi ; Rasanen, Juha. / Fetal oxygenation and Doppler ultrasonography of cardiovascular hemodynamics in a chronic near-term sheep model. In: American Journal of Obstetrics and Gynecology. 2006 ; Vol. 194, No. 2. pp. 542-550.
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