Fas stimulation results in selective islet infiltrate apoptosis in Situ and reversal of diabetes

Vikas R. Dharnidharka; Yancy Van Patten; F. Rena Bahjat; Michael Clare-Salzler

doi:10.1111/j.1749-6632.2002.tb02960.x

Fas stimulation results in selective islet infiltrate apoptosis in Situ and reversal of diabetes

Vikas R. Dharnidharka, Yancy Van Patten, F. Rena Bahjat, Michael Clare-Salzler

Molecular Microbiology and Immunology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Breakdown of peripheral T cell regulation due to defective antigen-activated apoptosis may lead to autoimmunity. In the nonobese diabetic (NOD) mouse model of type 1 diabetes mellitus, we have demonstrated defects in T cell activation and peripheral apoptosis. Stimulation of the Fas pathway by a Fas receptor agonist led to enhanced in vitro apoptosis and in vivo selective apoptosis of islet-infiltrating lymphocytes. Administration of the Fas agonist immediately after onset of diabetes led to reversal of diabetes in NOD mice. Inducing peripheral T cell apoptosis may be a potential method for reversal of autoimmune diabetes.

Original language	English (US)
Pages (from-to)	160-162
Number of pages	3
Journal	Annals of the New York Academy of Sciences
Volume	958
DOIs	https://doi.org/10.1111/j.1749-6632.2002.tb02960.x
State	Published - 2002

Keywords

Activation-induced cell death
T cell apoptosis
Type 1 diabetes mellitus

ASJC Scopus subject areas

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
History and Philosophy of Science

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10.1111/j.1749-6632.2002.tb02960.x

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abstract = "Breakdown of peripheral T cell regulation due to defective antigen-activated apoptosis may lead to autoimmunity. In the nonobese diabetic (NOD) mouse model of type 1 diabetes mellitus, we have demonstrated defects in T cell activation and peripheral apoptosis. Stimulation of the Fas pathway by a Fas receptor agonist led to enhanced in vitro apoptosis and in vivo selective apoptosis of islet-infiltrating lymphocytes. Administration of the Fas agonist immediately after onset of diabetes led to reversal of diabetes in NOD mice. Inducing peripheral T cell apoptosis may be a potential method for reversal of autoimmune diabetes.",

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AU - Dharnidharka, Vikas R.

AU - Van Patten, Yancy

AU - Rena Bahjat, F.

AU - Clare-Salzler, Michael

PY - 2002

Y1 - 2002

N2 - Breakdown of peripheral T cell regulation due to defective antigen-activated apoptosis may lead to autoimmunity. In the nonobese diabetic (NOD) mouse model of type 1 diabetes mellitus, we have demonstrated defects in T cell activation and peripheral apoptosis. Stimulation of the Fas pathway by a Fas receptor agonist led to enhanced in vitro apoptosis and in vivo selective apoptosis of islet-infiltrating lymphocytes. Administration of the Fas agonist immediately after onset of diabetes led to reversal of diabetes in NOD mice. Inducing peripheral T cell apoptosis may be a potential method for reversal of autoimmune diabetes.

AB - Breakdown of peripheral T cell regulation due to defective antigen-activated apoptosis may lead to autoimmunity. In the nonobese diabetic (NOD) mouse model of type 1 diabetes mellitus, we have demonstrated defects in T cell activation and peripheral apoptosis. Stimulation of the Fas pathway by a Fas receptor agonist led to enhanced in vitro apoptosis and in vivo selective apoptosis of islet-infiltrating lymphocytes. Administration of the Fas agonist immediately after onset of diabetes led to reversal of diabetes in NOD mice. Inducing peripheral T cell apoptosis may be a potential method for reversal of autoimmune diabetes.

KW - Activation-induced cell death

KW - T cell apoptosis

KW - Type 1 diabetes mellitus

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Fas stimulation results in selective islet infiltrate apoptosis in Situ and reversal of diabetes

Abstract

Keywords

ASJC Scopus subject areas

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