Fas stimulation results in selective islet infiltrate apoptosis in Situ and reversal of diabetes

Vikas R. Dharnidharka, Yancy Van Patten, F. Rena Bahjat, Michael Clare-Salzler

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Breakdown of peripheral T cell regulation due to defective antigen-activated apoptosis may lead to autoimmunity. In the nonobese diabetic (NOD) mouse model of type 1 diabetes mellitus, we have demonstrated defects in T cell activation and peripheral apoptosis. Stimulation of the Fas pathway by a Fas receptor agonist led to enhanced in vitro apoptosis and in vivo selective apoptosis of islet-infiltrating lymphocytes. Administration of the Fas agonist immediately after onset of diabetes led to reversal of diabetes in NOD mice. Inducing peripheral T cell apoptosis may be a potential method for reversal of autoimmune diabetes.

Original languageEnglish (US)
Pages (from-to)160-162
Number of pages3
JournalAnnals of the New York Academy of Sciences
Volume958
StatePublished - Jan 1 2002

Keywords

  • Activation-induced cell death
  • T cell apoptosis
  • Type 1 diabetes mellitus

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Fingerprint Dive into the research topics of 'Fas stimulation results in selective islet infiltrate apoptosis in Situ and reversal of diabetes'. Together they form a unique fingerprint.

  • Cite this

    Dharnidharka, V. R., Van Patten, Y., Rena Bahjat, F., & Clare-Salzler, M. (2002). Fas stimulation results in selective islet infiltrate apoptosis in Situ and reversal of diabetes. Annals of the New York Academy of Sciences, 958, 160-162.