Failure of breast cancer cells in long-term culture to aromatize androstenedione

R. D'Agata, M. E. Monaco, M. E. Lippman, D. L. Loriaux

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

The ability of breast cancer cells in long-term tissue culture to aromatize androstenedione to estrone and estradiol was examined. (3H) androstenedione (1.1 × 10-7M) was incubated with 9 cell lines of human breast cancer and one line derived froa a dimethylbenz(a)anthracene induced rat mammary tumor. No conversion to estrone or estradiol was detected. The findings are discussed in light of previous studies showing aromatization of androgens in breast cancer tissues.

Original languageEnglish (US)
Pages (from-to)463-470
Number of pages8
JournalSteroids
Volume31
Issue number4
DOIs
StatePublished - Apr 1978

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology
  • Pharmacology
  • Clinical Biochemistry
  • Organic Chemistry

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