Failure of breast cancer cells in long-term culture to aromatize androstenedione

R. D'Agata, M. E. Monaco, M. E. Lippman, Donald (Lynn) Loriaux

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The ability of breast cancer cells in long-term tissue culture to aromatize androstenedione to estrone and estradiol was examined. (3H) androstenedione (1.1 × 10-7M) was incubated with 9 cell lines of human breast cancer and one line derived froa a dimethylbenz(a)anthracene induced rat mammary tumor. No conversion to estrone or estradiol was detected. The findings are discussed in light of previous studies showing aromatization of androgens in breast cancer tissues.

Original languageEnglish (US)
Pages (from-to)463-470
Number of pages8
JournalSteroids
Volume31
Issue number4
DOIs
StatePublished - 1978
Externally publishedYes

Fingerprint

Androstenedione
Estrone
Cell culture
Estradiol
Cells
Breast Neoplasms
Aromatization
Tissue culture
Androgens
Rats
Tumors
Tissue
Cell Line
anthracene

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Molecular Biology

Cite this

Failure of breast cancer cells in long-term culture to aromatize androstenedione. / D'Agata, R.; Monaco, M. E.; Lippman, M. E.; Loriaux, Donald (Lynn).

In: Steroids, Vol. 31, No. 4, 1978, p. 463-470.

Research output: Contribution to journalArticle

D'Agata, R. ; Monaco, M. E. ; Lippman, M. E. ; Loriaux, Donald (Lynn). / Failure of breast cancer cells in long-term culture to aromatize androstenedione. In: Steroids. 1978 ; Vol. 31, No. 4. pp. 463-470.
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