Failure of antiplatelet and anticoagulant therapy to improve patency of grafts after coronary artery bypass

George Pantely, S. H. Goodnight, S. H. Rahimtoola, B. J. Harlan, H. DeMots, L. Calvin, Josef Rosch

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

Fifty patients who underwent aortocoronary saphenous-vein bypass-graft surgery were randomly assigned to one of three groups to determine the effects of antiplatelet or anticoagulant therapy on graft patency. Twenty-four patients served as controls; 13 patients received aspirin (325 mg three times a day) and dipyridamole (75 mg three times a day); and 13 patients received closely regulated warfarin therapy. Medications were begun on the third postoperative day. Six months after surgery, all patients underwent coronary angiography to assess graft patency. There were no statistically significant differences between groups in various clinical, hemodynamic and angiographic findings. Vein-graft patency was 50 of 61 grafts (82 per cent) in controls, 27 of 33 grafts (82 per cent) with aspirin and dipyridamole and 29 of 37 grafts (78 per cent) with warfarin (P

Original languageEnglish (US)
Pages (from-to)962-966
Number of pages5
JournalNew England Journal of Medicine
Volume301
Issue number18
StatePublished - 1979

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Coronary Artery Bypass
Anticoagulants
Transplants
Dipyridamole
Warfarin
Therapeutics
Aspirin
Saphenous Vein
Coronary Angiography
Veins
Hemodynamics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Pantely, G., Goodnight, S. H., Rahimtoola, S. H., Harlan, B. J., DeMots, H., Calvin, L., & Rosch, J. (1979). Failure of antiplatelet and anticoagulant therapy to improve patency of grafts after coronary artery bypass. New England Journal of Medicine, 301(18), 962-966.

Failure of antiplatelet and anticoagulant therapy to improve patency of grafts after coronary artery bypass. / Pantely, George; Goodnight, S. H.; Rahimtoola, S. H.; Harlan, B. J.; DeMots, H.; Calvin, L.; Rosch, Josef.

In: New England Journal of Medicine, Vol. 301, No. 18, 1979, p. 962-966.

Research output: Contribution to journalArticle

Pantely, G, Goodnight, SH, Rahimtoola, SH, Harlan, BJ, DeMots, H, Calvin, L & Rosch, J 1979, 'Failure of antiplatelet and anticoagulant therapy to improve patency of grafts after coronary artery bypass', New England Journal of Medicine, vol. 301, no. 18, pp. 962-966.
Pantely G, Goodnight SH, Rahimtoola SH, Harlan BJ, DeMots H, Calvin L et al. Failure of antiplatelet and anticoagulant therapy to improve patency of grafts after coronary artery bypass. New England Journal of Medicine. 1979;301(18):962-966.
Pantely, George ; Goodnight, S. H. ; Rahimtoola, S. H. ; Harlan, B. J. ; DeMots, H. ; Calvin, L. ; Rosch, Josef. / Failure of antiplatelet and anticoagulant therapy to improve patency of grafts after coronary artery bypass. In: New England Journal of Medicine. 1979 ; Vol. 301, No. 18. pp. 962-966.
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