F2-isoprostanes in Alzheimer and other neurodegenerative diseases

Thomas J. Montine, Kathleen S. Montine, Wendy McMahan, William R. Markesbery, Joseph Quinn, Jason D. Morrow

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

Increased free radical-mediated injury to brain is proposed to be an integral component of several neurodegenerative diseases, including Alzheimer's disease (AD). Lipid peroxidation is a major outcome of free radical-mediated injury to brain, where it directly damages membranes and generates a number of oxidized products. F2-Isoprostanes (F2-IsoPs), one group of lipid peroxidation products derived from arachidonic acid, are especially useful as in vivo biomarkers of lipid peroxidation. F2-IsoP concentration is selectively increased in diseased regions of brain from patients who died from advanced AD, where pathologic changes include amyloid β (Aβ) amyloidogenesis, neurofibrillary tangle formation, and extensive neuron death. Interestingly, cerebral F2-IsoPs are not reproducibly elevated in aged mouse models of cerebral Aβ amyloidogenesis only. There is broad agreement that increased cerebrospinal fluid (CSF) levels of F2-IsoPs also are present in patients with early AD. Demonstrated applications of quantifying CSF F2-IsoPs have improved laboratory diagnostic accuracy of AD and objective assessment of antioxidant therapeutics. In contrast, quantification of F2-IsoPs in plasma and urine of AD patients has produced conflicting data. These results indicate that brain lipid peroxidation is a potential therapeutic target early in the course of AD, and that CSF F 2-IsoPs may aid in the assessment of antioxidant experimental therapeutics and laboratory diagnosis of AD.

Original languageEnglish (US)
Pages (from-to)269-275
Number of pages7
JournalAntioxidants and Redox Signaling
Volume7
Issue number1-2
DOIs
StatePublished - Jan 2005
Externally publishedYes

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F2-Isoprostanes
Neurodegenerative diseases
Neurodegenerative Diseases
Alzheimer Disease
Cerebrospinal fluid
Lipid Peroxidation
Brain
Lipids
Cerebrospinal Fluid
Brain Injuries
Free Radicals
Antioxidants
Neurofibrillary Tangles
Clinical Laboratory Techniques
Brain Diseases
Biomarkers
Amyloid
Arachidonic Acid
Neurons
Therapeutics

ASJC Scopus subject areas

  • Biochemistry

Cite this

Montine, T. J., Montine, K. S., McMahan, W., Markesbery, W. R., Quinn, J., & Morrow, J. D. (2005). F2-isoprostanes in Alzheimer and other neurodegenerative diseases. Antioxidants and Redox Signaling, 7(1-2), 269-275. https://doi.org/10.1089/ars.2005.7.269

F2-isoprostanes in Alzheimer and other neurodegenerative diseases. / Montine, Thomas J.; Montine, Kathleen S.; McMahan, Wendy; Markesbery, William R.; Quinn, Joseph; Morrow, Jason D.

In: Antioxidants and Redox Signaling, Vol. 7, No. 1-2, 01.2005, p. 269-275.

Research output: Contribution to journalArticle

Montine, TJ, Montine, KS, McMahan, W, Markesbery, WR, Quinn, J & Morrow, JD 2005, 'F2-isoprostanes in Alzheimer and other neurodegenerative diseases', Antioxidants and Redox Signaling, vol. 7, no. 1-2, pp. 269-275. https://doi.org/10.1089/ars.2005.7.269
Montine, Thomas J. ; Montine, Kathleen S. ; McMahan, Wendy ; Markesbery, William R. ; Quinn, Joseph ; Morrow, Jason D. / F2-isoprostanes in Alzheimer and other neurodegenerative diseases. In: Antioxidants and Redox Signaling. 2005 ; Vol. 7, No. 1-2. pp. 269-275.
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