F2-isoprostanes in Alzheimer and other neurodegenerative diseases

Thomas J. Montine, Kathleen S. Montine, Wendy McMahan, William R. Markesbery, Joseph F. Quinn, Jason D. Morrow

Research output: Contribution to journalReview article

92 Scopus citations

Abstract

Increased free radical-mediated injury to brain is proposed to be an integral component of several neurodegenerative diseases, including Alzheimer's disease (AD). Lipid peroxidation is a major outcome of free radical-mediated injury to brain, where it directly damages membranes and generates a number of oxidized products. F2-Isoprostanes (F2-IsoPs), one group of lipid peroxidation products derived from arachidonic acid, are especially useful as in vivo biomarkers of lipid peroxidation. F2-IsoP concentration is selectively increased in diseased regions of brain from patients who died from advanced AD, where pathologic changes include amyloid β (Aβ) amyloidogenesis, neurofibrillary tangle formation, and extensive neuron death. Interestingly, cerebral F2-IsoPs are not reproducibly elevated in aged mouse models of cerebral Aβ amyloidogenesis only. There is broad agreement that increased cerebrospinal fluid (CSF) levels of F2-IsoPs also are present in patients with early AD. Demonstrated applications of quantifying CSF F2-IsoPs have improved laboratory diagnostic accuracy of AD and objective assessment of antioxidant therapeutics. In contrast, quantification of F2-IsoPs in plasma and urine of AD patients has produced conflicting data. These results indicate that brain lipid peroxidation is a potential therapeutic target early in the course of AD, and that CSF F 2-IsoPs may aid in the assessment of antioxidant experimental therapeutics and laboratory diagnosis of AD.

Original languageEnglish (US)
Pages (from-to)269-275
Number of pages7
JournalAntioxidants and Redox Signaling
Volume7
Issue number1-2
DOIs
StatePublished - Jan 1 2005

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ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

Cite this

Montine, T. J., Montine, K. S., McMahan, W., Markesbery, W. R., Quinn, J. F., & Morrow, J. D. (2005). F2-isoprostanes in Alzheimer and other neurodegenerative diseases. Antioxidants and Redox Signaling, 7(1-2), 269-275. https://doi.org/10.1089/ars.2005.7.269