F-ATPase of drosophila melanogaster forms 53-picosiemen (53-pS) channels responsible for mitochondrial Ca2+-induced Ca2+ release

Sophia Von Stockum; Valentina Giorgio; Elena Trevisan; Giovanna Lippe; Gary D. Glick; Michael A. Forte; Caterina Da-Rè; Vanessa Checchetto; Gabriella Mazzotta; Rodolfo Costa; Ildikò Szabò; Paolo Bernardi

doi:10.1074/jbc.C114.629766

F-ATPase of drosophila melanogaster forms 53-picosiemen (53-pS) channels responsible for mitochondrial Ca₂₊-induced Ca₂₊ release

Sophia Von Stockum, Valentina Giorgio, Elena Trevisan, Giovanna Lippe, Gary D. Glick, Michael A. Forte, Caterina Da-Rè, Vanessa Checchetto, Gabriella Mazzotta, Rodolfo Costa, Ildikò Szabò, Paolo Bernardi

Vollum Institute

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

Background: The Ca₂₊-induced Ca₂₊ release channel (mCrC) of Drosophila mitochondria is similar to the permeability transition pore (PTP). Results: mCrC is modulated by PTP effectors and Drosophila F-ATPase forms 53-pS channels. Conclusion: F-ATPase mediates Ca₂₊-induced Ca₂₊ release in Drosophila mitochondria. Significance: Channel formation by F-ATPases has been conserved in evolution, but species-specific features exist that may underscore different roles in different organisms.

Original language	English (US)
Pages (from-to)	4537-4544
Number of pages	8
Journal	Journal of Biological Chemistry
Volume	290
Issue number	8
DOIs	https://doi.org/10.1074/jbc.C114.629766
State	Published - Feb 20 2015

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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Von Stockum, S., Giorgio, V., Trevisan, E., Lippe, G., Glick, G. D., Forte, M. A., Da-Rè, C., Checchetto, V., Mazzotta, G., Costa, R., Szabò, I., & Bernardi, P. (2015). F-ATPase of drosophila melanogaster forms 53-picosiemen (53-pS) channels responsible for mitochondrial Ca₂₊-induced Ca₂₊ release. Journal of Biological Chemistry, 290(8), 4537-4544. https://doi.org/10.1074/jbc.C114.629766

Von Stockum, S, Giorgio, V, Trevisan, E, Lippe, G, Glick, GD, Forte, MA, Da-Rè, C, Checchetto, V, Mazzotta, G, Costa, R, Szabò, I & Bernardi, P 2015, 'F-ATPase of drosophila melanogaster forms 53-picosiemen (53-pS) channels responsible for mitochondrial Ca₂₊-induced Ca₂₊ release', Journal of Biological Chemistry, vol. 290, no. 8, pp. 4537-4544. https://doi.org/10.1074/jbc.C114.629766

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abstract = "Background: The Ca2+-induced Ca2+ release channel (mCrC) of Drosophila mitochondria is similar to the permeability transition pore (PTP). Results: mCrC is modulated by PTP effectors and Drosophila F-ATPase forms 53-pS channels. Conclusion: F-ATPase mediates Ca2+-induced Ca2+ release in Drosophila mitochondria. Significance: Channel formation by F-ATPases has been conserved in evolution, but species-specific features exist that may underscore different roles in different organisms.",

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doi = "10.1074/jbc.C114.629766",

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AU - Von Stockum, Sophia

AU - Giorgio, Valentina

AU - Trevisan, Elena

AU - Lippe, Giovanna

AU - Glick, Gary D.

AU - Forte, Michael A.

AU - Da-Rè, Caterina

AU - Checchetto, Vanessa

AU - Mazzotta, Gabriella

AU - Costa, Rodolfo

AU - Szabò, Ildikò

AU - Bernardi, Paolo

PY - 2015/2/20

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N2 - Background: The Ca2+-induced Ca2+ release channel (mCrC) of Drosophila mitochondria is similar to the permeability transition pore (PTP). Results: mCrC is modulated by PTP effectors and Drosophila F-ATPase forms 53-pS channels. Conclusion: F-ATPase mediates Ca2+-induced Ca2+ release in Drosophila mitochondria. Significance: Channel formation by F-ATPases has been conserved in evolution, but species-specific features exist that may underscore different roles in different organisms.

AB - Background: The Ca2+-induced Ca2+ release channel (mCrC) of Drosophila mitochondria is similar to the permeability transition pore (PTP). Results: mCrC is modulated by PTP effectors and Drosophila F-ATPase forms 53-pS channels. Conclusion: F-ATPase mediates Ca2+-induced Ca2+ release in Drosophila mitochondria. Significance: Channel formation by F-ATPases has been conserved in evolution, but species-specific features exist that may underscore different roles in different organisms.

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F-ATPase of drosophila melanogaster forms 53-picosiemen (53-pS) channels responsible for mitochondrial Ca₂₊-induced Ca₂₊ release

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