F-ATPase of drosophila melanogaster forms 53-picosiemen (53-pS) channels responsible for mitochondrial Ca2+-induced Ca2+ release

Sophia Von Stockum, Valentina Giorgio, Elena Trevisan, Giovanna Lippe, Gary D. Glick, Michael A. Forte, Caterina Da-Rè, Vanessa Checchetto, Gabriella Mazzotta, Rodolfo Costa, Ildikò Szabò, Paolo Bernardi

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

Background: The Ca2+-induced Ca2+ release channel (mCrC) of Drosophila mitochondria is similar to the permeability transition pore (PTP). Results: mCrC is modulated by PTP effectors and Drosophila F-ATPase forms 53-pS channels. Conclusion: F-ATPase mediates Ca2+-induced Ca2+ release in Drosophila mitochondria. Significance: Channel formation by F-ATPases has been conserved in evolution, but species-specific features exist that may underscore different roles in different organisms.

Original languageEnglish (US)
Pages (from-to)4537-4544
Number of pages8
JournalJournal of Biological Chemistry
Volume290
Issue number8
DOIs
StatePublished - Feb 20 2015

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Von Stockum, S., Giorgio, V., Trevisan, E., Lippe, G., Glick, G. D., Forte, M. A., Da-Rè, C., Checchetto, V., Mazzotta, G., Costa, R., Szabò, I., & Bernardi, P. (2015). F-ATPase of drosophila melanogaster forms 53-picosiemen (53-pS) channels responsible for mitochondrial Ca2+-induced Ca2+ release. Journal of Biological Chemistry, 290(8), 4537-4544. https://doi.org/10.1074/jbc.C114.629766