F-ATPase of drosophila melanogaster forms 53-picosiemen (53-pS) channels responsible for mitochondrial Ca2+-induced Ca2+ release

Sophia Von Stockum, Valentina Giorgio, Elena Trevisan, Giovanna Lippe, Gary D. Glick, Michael Forte, Caterina Da-Rè, Vanessa Checchetto, Gabriella Mazzotta, Rodolfo Costa, Ildikò Szabò, Paolo Bernardi

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Background: The Ca2+-induced Ca2+ release channel (mCrC) of Drosophila mitochondria is similar to the permeability transition pore (PTP). Results: mCrC is modulated by PTP effectors and Drosophila F-ATPase forms 53-pS channels. Conclusion: F-ATPase mediates Ca2+-induced Ca2+ release in Drosophila mitochondria. Significance: Channel formation by F-ATPases has been conserved in evolution, but species-specific features exist that may underscore different roles in different organisms.

Original languageEnglish (US)
Pages (from-to)4537-4544
Number of pages8
JournalJournal of Biological Chemistry
Volume290
Issue number8
DOIs
StatePublished - Feb 20 2015

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Mitochondria
Drosophila melanogaster
Drosophila
Adenosine Triphosphatases
Calcium-Transporting ATPases
Permeability

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

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F-ATPase of drosophila melanogaster forms 53-picosiemen (53-pS) channels responsible for mitochondrial Ca2+-induced Ca2+ release. / Von Stockum, Sophia; Giorgio, Valentina; Trevisan, Elena; Lippe, Giovanna; Glick, Gary D.; Forte, Michael; Da-Rè, Caterina; Checchetto, Vanessa; Mazzotta, Gabriella; Costa, Rodolfo; Szabò, Ildikò; Bernardi, Paolo.

In: Journal of Biological Chemistry, Vol. 290, No. 8, 20.02.2015, p. 4537-4544.

Research output: Contribution to journalArticle

Von Stockum, S, Giorgio, V, Trevisan, E, Lippe, G, Glick, GD, Forte, M, Da-Rè, C, Checchetto, V, Mazzotta, G, Costa, R, Szabò, I & Bernardi, P 2015, 'F-ATPase of drosophila melanogaster forms 53-picosiemen (53-pS) channels responsible for mitochondrial Ca2+-induced Ca2+ release', Journal of Biological Chemistry, vol. 290, no. 8, pp. 4537-4544. https://doi.org/10.1074/jbc.C114.629766
Von Stockum, Sophia ; Giorgio, Valentina ; Trevisan, Elena ; Lippe, Giovanna ; Glick, Gary D. ; Forte, Michael ; Da-Rè, Caterina ; Checchetto, Vanessa ; Mazzotta, Gabriella ; Costa, Rodolfo ; Szabò, Ildikò ; Bernardi, Paolo. / F-ATPase of drosophila melanogaster forms 53-picosiemen (53-pS) channels responsible for mitochondrial Ca2+-induced Ca2+ release. In: Journal of Biological Chemistry. 2015 ; Vol. 290, No. 8. pp. 4537-4544.
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