Eye, orbit, and adnexal structures

Daniel M. Albert, Marni Feldmann, Heather Potter, Amit Kumar

Research output: Chapter in Book/Report/Conference proceedingChapter


Two distinct populations of pigmented cells can be found in the eye. The pigmented epithelial cells of the iris, ciliary body, and retina are derived from the neural tube. These cells undergo reactive hyperplasia in response to a variety of stimuli, but they only rarely undergo malignant transformation. The other population consists of the stromal melanocytes, which can be found in the skin, conjunctiva, and uveal tract. These are neural crest in origin and do not undergo reactive hyperplasia, but they are the source of the most common primary intraocular tumor: uveal melanoma. The uveal melanocytes are considered the counterpart of dermal melanocytes, the source of cutaneous melanoma. (Dermal melanoma is discussed elsewhere in this text. This chapter focuses on eye-related melanomas.)

Original languageEnglish (US)
Title of host publicationOncology
Subtitle of host publicationAn Evidence-Based Approach
PublisherSpringer New York
Number of pages29
ISBN (Print)0387242910, 9780387242910
StatePublished - 2006
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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