Expression of VPAC2 receptor and PAC1 receptor splice variants in the trigeminal ganglion of the adult rat.

Priya Chaudhary, Thomas Baumann

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

PACAP and VIP are members of the VIP/secretin/glucagon family of peptides with neurotransmitter, neuroprotective, and neurotrophic functions. PACAP and VIP are known to be upregulated in primary sensory neurons following nerve injury, implying that these neuropeptides could be mediators of sensory transmission in neuropathic pain states. Nerve injury at the level of the trigeminal root is thought to be the prime cause of trigeminal neuralgia. Since cross-excitation (a chemically-mediated form of nonsynaptic transmission) within the TG is postulated to play a central role in trigeminal neuralgia, we studied the expression of PACAP and VIP receptors in the TG by RT PCR and immunocytochemistry. Of the three known receptors (PAC1, VPAC1 and VPAC2), RT PCR revealed the presence of mRNA for VPAC2 and several splice variants of the PAC1 receptor. Immunocytochemistry showed PAC1 and VPAC2 to be present in small-diameter TG neurons. Thus, PACAP and VIP are potential mediators of cross-excitation in the TG.

Original languageEnglish (US)
Pages (from-to)137-142
Number of pages6
JournalMolecular Brain Research
Volume104
Issue number2
StatePublished - Aug 15 2002

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Receptors, Vasoactive Intestinal Peptide, Type II
Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I
Pituitary Adenylate Cyclase-Activating Polypeptide
Trigeminal Ganglion
Trigeminal Neuralgia
Receptors, Vasoactive Intestinal Polypeptide, Type I
Pituitary Adenylate Cyclase-Activating Polypeptide Receptors
Immunohistochemistry
Vasoactive Intestinal Peptide Receptors
Polymerase Chain Reaction
Secretin
Wounds and Injuries
Neuralgia
Sensory Receptor Cells
Neuropeptides
Glucagon
Neurotransmitter Agents
Neurons
Messenger RNA
Peptides

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

Cite this

Expression of VPAC2 receptor and PAC1 receptor splice variants in the trigeminal ganglion of the adult rat. / Chaudhary, Priya; Baumann, Thomas.

In: Molecular Brain Research, Vol. 104, No. 2, 15.08.2002, p. 137-142.

Research output: Contribution to journalArticle

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