Expression of fasciclin I and II glycoproteins on subsets of axon pathways during neuronal development in the grasshopper

Michael J. Bastiani, Allan Harrelson, Peter M. Snow, Corey S. Goodman

Research output: Contribution to journalArticle

271 Citations (Scopus)

Abstract

The "labeled pathways" hypothesis predicts that axon fascicles in the embryonic neuropil are differentially labeled by surface recognition molecules used for growth cone guidance. To identify candidates for such recognition molecules, we generated monoclonal antibodies (MAbs) that recognize surface antigens expressed on subsets of axon fascicles in the grasshopper embryo. The 3B11 and 8C6 MAbs immunoprecipitate 70- and 95-kd membrane glycoproteins called fasciclin I and II, respectively, which are expressed on different subsets of axon fascicles during development. These two glycoproteins are expressed regionally on particular portions of embryonic axons in correlation with their patterns of fasciculation, dynamically during the period of axon outgrowth in a manner consistent with a role in growth cone guidance, and at other times and places during embryogenesis, suggesting multiple developmental roles.

Original languageEnglish (US)
Pages (from-to)745-755
Number of pages11
JournalCell
Volume48
Issue number5
DOIs
StatePublished - Mar 13 1987
Externally publishedYes

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Grasshoppers
Axons
Glycoproteins
Growth Cones
Monoclonal Antibodies
Cones
Fasciculation
Neuropil
Membrane Glycoproteins
Surface Antigens
Molecules
Embryonic Development
Embryonic Structures
fasciclin II
fasciclin I

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Expression of fasciclin I and II glycoproteins on subsets of axon pathways during neuronal development in the grasshopper. / Bastiani, Michael J.; Harrelson, Allan; Snow, Peter M.; Goodman, Corey S.

In: Cell, Vol. 48, No. 5, 13.03.1987, p. 745-755.

Research output: Contribution to journalArticle

Bastiani, Michael J. ; Harrelson, Allan ; Snow, Peter M. ; Goodman, Corey S. / Expression of fasciclin I and II glycoproteins on subsets of axon pathways during neuronal development in the grasshopper. In: Cell. 1987 ; Vol. 48, No. 5. pp. 745-755.
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