Expression of a tumor-related gene network increases in the mammalian hypothalamus at the time of female puberty

Christian L. Roth, Claudio Mastronardi, Alejandro Lomniczi, Hollis Wright, Ricardo Cabrera, Alison E. Mungenast, Sabine Heger, Heike Jung, Christopher Dubay, Sergio Ojeda

    Research output: Contribution to journalArticle

    62 Citations (Scopus)

    Abstract

    Much has been learned in recent years about the central mechanisms controlling the initiation of mammalian puberty. It is now clear that this process requires the interactive participation of several genes. Using a combination of high throughput, molecular, and bioinformatics strategies, in combination with a system biology approach, we singled out from the hypothalamus of nonhuman primates and rats a group of related genes whose expression increases at the time of female puberty. Although these genes [henceforth termed tumor-related genes (TRGs)] have diverse cellular functions, they share the common feature of having been earlier identified as involved in tumor suppression/tumor formation. A prominent member of this group is KiSS1, a gene recently shown to be essential for the occurrence of puberty. Cis-regulatory analysis revealed the presence of a hierarchically arranged gene set containing five major hubs (CDP/CUTL1, MAF, p53, YY1, and USF2) controlling the network at the transcriptional level. In turn, these hubs are heavily connected to non-TRGs involved in the transcriptional regulation of the pubertal process. TRGsmaybe expressed in themammalianhypothalamus as components of a regulatory gene network that facilitates and integrates cellular and cell-cell communication programs required for the acquisition of female reproductive competence.

    Original languageEnglish (US)
    Pages (from-to)5147-5161
    Number of pages15
    JournalEndocrinology
    Volume148
    Issue number11
    DOIs
    StatePublished - Nov 2007

    Fingerprint

    Gene Regulatory Networks
    Puberty
    Hypothalamus
    Genes
    Neoplasms
    Cytidine Diphosphate
    Systems Biology
    Computational Biology
    Cell Communication
    Mental Competency
    Primates
    Communication
    Gene Expression

    ASJC Scopus subject areas

    • Endocrinology
    • Endocrinology, Diabetes and Metabolism

    Cite this

    Expression of a tumor-related gene network increases in the mammalian hypothalamus at the time of female puberty. / Roth, Christian L.; Mastronardi, Claudio; Lomniczi, Alejandro; Wright, Hollis; Cabrera, Ricardo; Mungenast, Alison E.; Heger, Sabine; Jung, Heike; Dubay, Christopher; Ojeda, Sergio.

    In: Endocrinology, Vol. 148, No. 11, 11.2007, p. 5147-5161.

    Research output: Contribution to journalArticle

    Roth, CL, Mastronardi, C, Lomniczi, A, Wright, H, Cabrera, R, Mungenast, AE, Heger, S, Jung, H, Dubay, C & Ojeda, S 2007, 'Expression of a tumor-related gene network increases in the mammalian hypothalamus at the time of female puberty', Endocrinology, vol. 148, no. 11, pp. 5147-5161. https://doi.org/10.1210/en.2007-0634
    Roth, Christian L. ; Mastronardi, Claudio ; Lomniczi, Alejandro ; Wright, Hollis ; Cabrera, Ricardo ; Mungenast, Alison E. ; Heger, Sabine ; Jung, Heike ; Dubay, Christopher ; Ojeda, Sergio. / Expression of a tumor-related gene network increases in the mammalian hypothalamus at the time of female puberty. In: Endocrinology. 2007 ; Vol. 148, No. 11. pp. 5147-5161.
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