Abstract
A model is presented which explains the biological role of the leader peptide in protein export. Along the lines of this model, the conformational changes of a protein with environment serves as a general mechanism for translocation. The leader peptide in the cytoplasm takes a hairpin like conformation which reverts to an extended helix upon integration into the membrane. The essential features of this model are in accord with recent results of protein export.
Original language | English (US) |
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Pages (from-to) | 737-745 |
Number of pages | 9 |
Journal | Bioscience Reports |
Volume | 9 |
Issue number | 6 |
DOIs | |
State | Published - Dec 1989 |
Externally published | Yes |
Keywords
- conformational changes
- hairpin helix
- leader peptides
- protein export
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology