Experimental nonsurgical female sterilization

transcervical implantation of microspindles in fallopian tubes.

T. Schmitz-Rode, P. L. Ross, H. Timmermans, A. S. Thurmond, R. W. Günther, Josef Rosch

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

PURPOSE: A nonsurgical method of female sterilization was investigated in rabbits. MATERIALS AND METHODS: A self-expanding microspindle (length 9-18 mm, diameter 1.5-2.0 mm) made from tubular metal mesh was implanted in a single fallopian tube of 12 rabbits via catheterization of a single uterus. The contralateral fallopian tube and uterus served as controls. Each rabbit was scheduled to undergo three cycles of breeding. Before delivery, absence of pregnancy on the side with the microspindle was verified with hysterography. RESULTS: Eight rabbits completed three cycles of breeding and pregnancy. Two rabbits had one pregnancy. Two rabbits did not conceive. Spindles were placed correctly in 11 rabbits. Successful contraception was achieved in nine rabbits, who had 25 gestations on the nonspindle side and no gestation on the spindle side. One rabbit, which received the shortest spindle, was bilaterally pregnant, indicating a failure of contraception on the spindle side. No spindles dislocated. Histologic study showed all spindles firmly embedded in the tubal wall without signs of inflammation. CONCLUSION: Microspindles of a certain minimum length have potential as a transcervically implantable, permanent intratubal contraceptive device.

Original languageEnglish (US)
Pages (from-to)905-910
Number of pages6
JournalJournal of vascular and interventional radiology : JVIR
Volume5
Issue number6
StatePublished - Nov 1994
Externally publishedYes

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Reproductive Sterilization
Fallopian Tubes
Rabbits
Pregnancy
Contraception
Uterus
Breeding
Contraceptive Devices
Catheterization
Metals
Inflammation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Schmitz-Rode, T., Ross, P. L., Timmermans, H., Thurmond, A. S., Günther, R. W., & Rosch, J. (1994). Experimental nonsurgical female sterilization: transcervical implantation of microspindles in fallopian tubes. Journal of vascular and interventional radiology : JVIR, 5(6), 905-910.

Experimental nonsurgical female sterilization : transcervical implantation of microspindles in fallopian tubes. / Schmitz-Rode, T.; Ross, P. L.; Timmermans, H.; Thurmond, A. S.; Günther, R. W.; Rosch, Josef.

In: Journal of vascular and interventional radiology : JVIR, Vol. 5, No. 6, 11.1994, p. 905-910.

Research output: Contribution to journalArticle

Schmitz-Rode, T, Ross, PL, Timmermans, H, Thurmond, AS, Günther, RW & Rosch, J 1994, 'Experimental nonsurgical female sterilization: transcervical implantation of microspindles in fallopian tubes.', Journal of vascular and interventional radiology : JVIR, vol. 5, no. 6, pp. 905-910.
Schmitz-Rode, T. ; Ross, P. L. ; Timmermans, H. ; Thurmond, A. S. ; Günther, R. W. ; Rosch, Josef. / Experimental nonsurgical female sterilization : transcervical implantation of microspindles in fallopian tubes. In: Journal of vascular and interventional radiology : JVIR. 1994 ; Vol. 5, No. 6. pp. 905-910.
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N2 - PURPOSE: A nonsurgical method of female sterilization was investigated in rabbits. MATERIALS AND METHODS: A self-expanding microspindle (length 9-18 mm, diameter 1.5-2.0 mm) made from tubular metal mesh was implanted in a single fallopian tube of 12 rabbits via catheterization of a single uterus. The contralateral fallopian tube and uterus served as controls. Each rabbit was scheduled to undergo three cycles of breeding. Before delivery, absence of pregnancy on the side with the microspindle was verified with hysterography. RESULTS: Eight rabbits completed three cycles of breeding and pregnancy. Two rabbits had one pregnancy. Two rabbits did not conceive. Spindles were placed correctly in 11 rabbits. Successful contraception was achieved in nine rabbits, who had 25 gestations on the nonspindle side and no gestation on the spindle side. One rabbit, which received the shortest spindle, was bilaterally pregnant, indicating a failure of contraception on the spindle side. No spindles dislocated. Histologic study showed all spindles firmly embedded in the tubal wall without signs of inflammation. CONCLUSION: Microspindles of a certain minimum length have potential as a transcervically implantable, permanent intratubal contraceptive device.

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