TY - JOUR
T1 - Experimental Nonsurgical Female Sterilization
T2 - Transcervical Implantation of Microspindles in Fallopian Tubes
AU - Schmitz-Rode, Thomas
AU - Ross, Penny L.
AU - Timmermans, Hans
AU - Thurmond, Amy S.
AU - Günther, Rolf W.
AU - Rösch, Josef
PY - 1994/1/1
Y1 - 1994/1/1
N2 - A nonsurgical method of female sterilization was investigated in rabbits. A self-expanding microspindle (length 9–18 mm, diameter 1.5–2.0 mm) made from tubular metal mesh was implanted in a single fallopian tube of 12 rabbits via catheterization of a single uterus. The contralateral fallopian tube and uterus served as controls. Each rabbit was scheduled to undergo three cycles of breeding. Before delivery, absence of pregnancy on the side with the microspindle was verified with hysterography. Eight rabbits completed three cycles of breeding and pregnancy. Two rabbits had one pregnancy. Two rabbits did not conceive. Spindles were placed correctly in 11 rabbits. Successful contraception was achieved in nine rabbits, who had 25 gestations on the nonspindle side and no gestation on the spindle side. One rabbit, which received the shortest spindle, was bilaterally pregnant, indicating a failure of contraception on the spindle side. No spindles dislocated. Histologic study showed all spindles firmly embedded in the tubal wall without signs of inflammation. Microspindles of a certain minimum length have potential as a transcervically implantable, permanent intratubal contraceptive device.
AB - A nonsurgical method of female sterilization was investigated in rabbits. A self-expanding microspindle (length 9–18 mm, diameter 1.5–2.0 mm) made from tubular metal mesh was implanted in a single fallopian tube of 12 rabbits via catheterization of a single uterus. The contralateral fallopian tube and uterus served as controls. Each rabbit was scheduled to undergo three cycles of breeding. Before delivery, absence of pregnancy on the side with the microspindle was verified with hysterography. Eight rabbits completed three cycles of breeding and pregnancy. Two rabbits had one pregnancy. Two rabbits did not conceive. Spindles were placed correctly in 11 rabbits. Successful contraception was achieved in nine rabbits, who had 25 gestations on the nonspindle side and no gestation on the spindle side. One rabbit, which received the shortest spindle, was bilaterally pregnant, indicating a failure of contraception on the spindle side. No spindles dislocated. Histologic study showed all spindles firmly embedded in the tubal wall without signs of inflammation. Microspindles of a certain minimum length have potential as a transcervically implantable, permanent intratubal contraceptive device.
KW - Contraceptives and contraceptive devices
KW - Fallopian tubes, interventional procedure, 853.1269
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U2 - 10.1016/S1051-0443(94)71635-3
DO - 10.1016/S1051-0443(94)71635-3
M3 - Article
C2 - 7873873
AN - SCOPUS:0028537248
VL - 5
SP - 905
EP - 910
JO - Journal of Vascular and Interventional Radiology
JF - Journal of Vascular and Interventional Radiology
SN - 1051-0443
IS - 6
ER -