Experimental microbial dysbiosis does not promote disease progression in SIV-infected macaques

Alexandra M. Ortiz; Jacob K. Flynn; Sarah R. DiNapoli; Ivan Vujkovic-Cvijin; Carly E. Starke; Stephen H. Lai; MacKenzie K.E. Long; Ornella Sortino; Carol L. Vinton; Joseph C. Mudd; Leslie Johnston; Kathleen Busman-Sahay; Yasmine Belkaid; Jacob D. Estes; Jason M. Brenchley

doi:10.1038/s41591-018-0132-5

Experimental microbial dysbiosis does not promote disease progression in SIV-infected macaques

Alexandra M. Ortiz, Jacob K. Flynn, Sarah R. DiNapoli, Ivan Vujkovic-Cvijin, Carly E. Starke, Stephen H. Lai, MacKenzie K.E. Long, Ornella Sortino, Carol L. Vinton, Joseph C. Mudd, Leslie Johnston, Kathleen Busman-Sahay, Yasmine Belkaid, Jacob D. Estes, Jason M. Brenchley

Vaccine and Gene Therapy Institute

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Intestinal microbial dysbiosis has been described in individuals with an HIV-1 infection and may underlie persistent inflammation in chronic infection, thereby contributing to disease progression. Herein, we induced an HIV-1-like intestinal dysbiosis in rhesus macaques (Macaca mulatta) with vancomycin treatment and assessed the contribution of dysbiosis to SIV disease progression. Dysbiotic and control animals had similar disease progression, indicating that intestinal microbial dysbiosis similar to that observed in individuals with HIV is not sufficient to accelerate untreated lentiviral disease progression.

Original language	English (US)
Pages (from-to)	1313-1316
Number of pages	4
Journal	Nature medicine
Volume	24
Issue number	9
DOIs	https://doi.org/10.1038/s41591-018-0132-5
State	Published - Sep 1 2018

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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Ortiz, A. M., Flynn, J. K., DiNapoli, S. R., Vujkovic-Cvijin, I., Starke, C. E., Lai, S. H., Long, M. K. E., Sortino, O., Vinton, C. L., Mudd, J. C., Johnston, L., Busman-Sahay, K., Belkaid, Y., Estes, J. D., & Brenchley, J. M. (2018). Experimental microbial dysbiosis does not promote disease progression in SIV-infected macaques. Nature medicine, 24(9), 1313-1316. https://doi.org/10.1038/s41591-018-0132-5

Ortiz, AM, Flynn, JK, DiNapoli, SR, Vujkovic-Cvijin, I, Starke, CE, Lai, SH, Long, MKE, Sortino, O, Vinton, CL, Mudd, JC, Johnston, L, Busman-Sahay, K, Belkaid, Y, Estes, JD & Brenchley, JM 2018, 'Experimental microbial dysbiosis does not promote disease progression in SIV-infected macaques', Nature medicine, vol. 24, no. 9, pp. 1313-1316. https://doi.org/10.1038/s41591-018-0132-5

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abstract = "Intestinal microbial dysbiosis has been described in individuals with an HIV-1 infection and may underlie persistent inflammation in chronic infection, thereby contributing to disease progression. Herein, we induced an HIV-1-like intestinal dysbiosis in rhesus macaques (Macaca mulatta) with vancomycin treatment and assessed the contribution of dysbiosis to SIV disease progression. Dysbiotic and control animals had similar disease progression, indicating that intestinal microbial dysbiosis similar to that observed in individuals with HIV is not sufficient to accelerate untreated lentiviral disease progression.",

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AU - Starke, Carly E.

AU - Lai, Stephen H.

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AU - Mudd, Joseph C.

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Experimental microbial dysbiosis does not promote disease progression in SIV-infected macaques

Abstract

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