Expectancy effect: Impact of pill administration on cognitive performance in healthy seniors

Barry Oken, Kristin Flegal, Daniel Zajdel, Shirley Kishiyama, Mitchell Haas, Dawn Peters

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Expectancy or placebo effects on cognitive function have not been well studied. To determine the effect of taking pills on cognitive function, 40 participants were randomly assigned to a pill or no-pill condition. Healthy seniors who took a 2-week supply of methylcellulose pills, which they were told was an experimental cognitive enhancer, were compared to seniors not taking any pills. There were 2 primary outcome measures defined prior to the study - Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Word List delayed recall and Stroop color word task time - as well as 7 other cognitive outcome measures. There was a significant effect of pill taking on the 2 primary outcome measures. There was also an effect of pill taking on choice reaction time and Word List immediate recall but not on the other 5 secondary cognitive outcome measures. In an exploratory analysis of potential predictors of the expectancy effect, perceived stress and self-efficacy but not personality traits interacted with the pill-taking effect on cognitive function. Further characterizing and understanding this observed expectancy effect is important to maximize cognitive health and improve clinical trial design.

Original languageEnglish (US)
Pages (from-to)7-17
Number of pages11
JournalJournal of Clinical and Experimental Neuropsychology
Volume30
Issue number1
DOIs
StatePublished - Jan 2008

Fingerprint

Outcome Assessment (Health Care)
Cognition
Nootropic Agents
Placebo Effect
Methylcellulose
Self Efficacy
Short-Term Memory
Reaction Time
Personality
Registries
Alzheimer Disease
Color
Clinical Trials
Health

Keywords

  • Attention
  • Geriatrics
  • Memory
  • Placebo effect
  • Self-efficacy
  • Stress

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Psychology(all)
  • Clinical Psychology

Cite this

Expectancy effect : Impact of pill administration on cognitive performance in healthy seniors. / Oken, Barry; Flegal, Kristin; Zajdel, Daniel; Kishiyama, Shirley; Haas, Mitchell; Peters, Dawn.

In: Journal of Clinical and Experimental Neuropsychology, Vol. 30, No. 1, 01.2008, p. 7-17.

Research output: Contribution to journalArticle

Oken, Barry ; Flegal, Kristin ; Zajdel, Daniel ; Kishiyama, Shirley ; Haas, Mitchell ; Peters, Dawn. / Expectancy effect : Impact of pill administration on cognitive performance in healthy seniors. In: Journal of Clinical and Experimental Neuropsychology. 2008 ; Vol. 30, No. 1. pp. 7-17.
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