Expanded tissue targets for foamy virus replication with simian immunodeficiency virus-induced immunosuppression

S. M. Murray, Louis Picker, Michael Axthelm, M. L. Linial

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60 Citations (Scopus)

Abstract

Foamy viruses (FV) are the oldest known genus of retroviruses and have persisted in nonhuman primates for over 60 million years. FV are efficiently transmitted, leading to a lifelong nonpathogenic infection. Transmission is thought to occur through saliva, but the detailed mechanism is unknown. Interestingly, this persistent infection contrasts with the rapid cytopathicity caused by FV in vitro, suggesting a host defense against FV. To better understand the tissue specificity of FV replication and host immunologic defense against FV cytopathicity, we quantified FV in tissues of healthy rhesus macaques (RM) and those severely immunosuppressed by simian immunodeficiency virus (SIV). Contrary to earlier findings, we find that all immunocompetent animals consistently have high levels of viral RNA in oral tissues but not in other tissues examined, including the small intestine. Strikingly, abundant viral transcripts were detected in the small intestine of all of the SIV-infected RM, which has been shown to be a major site of SIV (and human immunodeficiency virus)-induced CD4+ T-cell depletion. In contrast, there was a trend to lower viral RNA levels in oropharyngeal tissues of SIV-infected animals. The expansion of FV replication to the small intestine but not to other CD4+ T-cell-depleted tissues suggests that factors other than T-cell depletion, such as dysregulation of the jejunal microenvironment after SIV infection, likely account for the expanded tissue tropism of FV replication.

Original languageEnglish (US)
Pages (from-to)663-670
Number of pages8
JournalJournal of Virology
Volume80
Issue number2
DOIs
StatePublished - Jan 2006

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Spumavirus
Simian immunodeficiency virus
Simian Immunodeficiency Virus
immunosuppression
Virus Replication
virus replication
Immunosuppression
viruses
small intestine
T-lymphocytes
Macaca mulatta
Small Intestine
Retroviridae
Viral RNA
infection
RNA
tissue tropism
T-Lymphocytes
Human immunodeficiency virus
saliva

ASJC Scopus subject areas

  • Immunology

Cite this

Expanded tissue targets for foamy virus replication with simian immunodeficiency virus-induced immunosuppression. / Murray, S. M.; Picker, Louis; Axthelm, Michael; Linial, M. L.

In: Journal of Virology, Vol. 80, No. 2, 01.2006, p. 663-670.

Research output: Contribution to journalArticle

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