Exercise level and cognitive decline

The MoVIES project

Mary Ellen Lytle, Joni Vander Bilt, Rajesh S. Pandav, Hiroko Dodge, Mary Ganguli

Research output: Contribution to journalArticle

144 Citations (Scopus)

Abstract

Growing evidence suggests that physical exercise may be protective against cognitive impairment and decline. A prospective study of a representative rural community sample (N = 1,146) aged 65+ years examined self-reported exercise habits and measured global cognitive function using the Mini-Mental State Examination (MMSE). A composite variable "exercise level" combining type, frequency, and duration of exercise was created with three levels: "high exercise" (aerobic exercise of ≥ 30 minute duration ≥ 3 times a week), "low exercise" (all other exercise groups), and "no exercise." Cognitive decline was defined as being in the 90 th percentile of decline in this cohort, ie, declining by 3 or more MMSE points during the 2-year interval between two assessments. In a multiple regression model, high exercise level at the baseline assessment was negatively associated with, ie, was protective against, being in the group with the greatest amount of decline at the follow-up assessment, after adjusting for likely confounders (odds ratio = 0.39; 95% confidence interval, 0.19, 0.78). When high exercise was redefined using frequency as ≥ 5 days per week as the threshold, as per the Surgeon General's guidelines, both low exercise and high exercise were negatively associated with cognitive decline. Exercise may have implications for prevention of cognitive decline.

Original languageEnglish (US)
Pages (from-to)57-64
Number of pages8
JournalAlzheimer Disease and Associated Disorders
Volume18
Issue number2
DOIs
StatePublished - Apr 2004
Externally publishedYes

Fingerprint

Exercise
Cognitive Dysfunction
Rural Population
Cognition
Habits
Odds Ratio
Prospective Studies
Guidelines
Confidence Intervals

Keywords

  • Cognitive status
  • Epidemiology
  • Exercise

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Neuroscience(all)

Cite this

Exercise level and cognitive decline : The MoVIES project. / Lytle, Mary Ellen; Vander Bilt, Joni; Pandav, Rajesh S.; Dodge, Hiroko; Ganguli, Mary.

In: Alzheimer Disease and Associated Disorders, Vol. 18, No. 2, 04.2004, p. 57-64.

Research output: Contribution to journalArticle

Lytle, Mary Ellen ; Vander Bilt, Joni ; Pandav, Rajesh S. ; Dodge, Hiroko ; Ganguli, Mary. / Exercise level and cognitive decline : The MoVIES project. In: Alzheimer Disease and Associated Disorders. 2004 ; Vol. 18, No. 2. pp. 57-64.
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