Evolutionary movement of centromeres in horse, donkey, and zebra

Lucia Carbone, Solomon G. Nergadze, Elisa Magnani, Doriana Misceo, Maria Francesca Cardone, Roberta Roberto, Livia Bertoni, Carmen Attolini, Maria Francesca Piras, Pieter de Jong, Terje Raudsepp, Bhanu P. Chowdhary, Gérard Guérin, Nicoletta Archidiacono, Mariano Rocchi, Elena Giulotto

Research output: Contribution to journalArticle

73 Scopus citations

Abstract

Centromere repositioning (CR) is a recently discovered biological phenomenon consisting of the emergence of a new centromere along a chromosome and the inactivation of the old one. After a CR, the primary constriction and the centromeric function are localized in a new position while the order of physical markers on the chromosome remains unchanged. These events profoundly affect chromosomal architecture. Since horses, asses, and zebras, whose evolutionary divergence is relatively recent, show remarkable morphological similarity and capacity to interbreed despite their chromosomes differing considerably, we investigated the role of CR in the karyotype evolution of the genus Equus. Using appropriate panels of BAC clones in FISH experiments, we compared the centromere position and marker order arrangement among orthologous chromosomes of Burchelli's zebra (Equus burchelli), donkey (Equus asinus), and horse (Equus caballus). Surprisingly, at least eight CRs took place during the evolution of this genus. Even more surprisingly, five cases of CR have occurred in the donkey after its divergence from zebra, that is, in a very short evolutionary time (approximately 1 million years).These findings suggest that in some species the CR phenomenon could have played an important role in karyotype shaping, with potential consequences on population dynamics and speciation.

Original languageEnglish (US)
Pages (from-to)777-782
Number of pages6
JournalGenomics
Volume87
Issue number6
DOIs
StatePublished - Jun 2006

Keywords

  • Centromere
  • Centromere repositioning
  • Donkey
  • Evolution
  • Horse

ASJC Scopus subject areas

  • Genetics

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    Carbone, L., Nergadze, S. G., Magnani, E., Misceo, D., Francesca Cardone, M., Roberto, R., Bertoni, L., Attolini, C., Francesca Piras, M., de Jong, P., Raudsepp, T., Chowdhary, B. P., Guérin, G., Archidiacono, N., Rocchi, M., & Giulotto, E. (2006). Evolutionary movement of centromeres in horse, donkey, and zebra. Genomics, 87(6), 777-782. https://doi.org/10.1016/j.ygeno.2005.11.012