Evolutionary and biomedical insights from the rhesus macaque genome

Richard A. Gibbs; Jeffrey Rogers; Michael G. Katze; Roger Bumgarner; George M. Weinstock; Elaine R. Mardis; Karin A. Remington; Robert L. Strausberg; J. Craig Venter; Richard K. Wilson; Mark A. Batzer; Carlos D. Bustamante; Evan E. Eichler; Matthew W. Hahn; Ross C. Hardison; Kateryna D. Makova; Webb Miller; Aleksandar Milosavljevic; Robert E. Palermo; Adam Siepel; James M. Sikela; Tony Attaway; Stephanie Bell; Kelly E. Bernard; Christian J. Buhay; Mimi N. Chandrabose; Marvin Dao; Clay Davis; Kimberly D. Delehaunty; Yan Ding; Huyen H. Dinh; Shannon Dugan-Rocha; Lucinda A. Fulton; Ramatu Ayiesha Gabisi; Toni T. Garner; Jennifer Godfrey; Alicia C. Hawes; Judith Hernandez; Sandra Hines; Michael Holder; Jennifer Hume; Shalini N. Jhangiani; Vandita Joshi; Ziad Mohid Khan; Ewen F. Kirkness; Andrew Cree; R. Gerald Fowler; Sandra Lee; Lora R. Lewis; Zhangwan Li; Yih Shin Liu; Stephanie M. Moore; Donna Muzny; Lynne V. Nazareth; Ngoc Ngo Dinh; Geoffrey O. Okwuonu; Grace Pai; David Parker; Heidie A. Paul; Cynthia Pfannkoch; Craig S. Pohl; Yu Hui Rogers; San Juana Ruiz; Aniko Sabo; Jireh Santibanez; Brian W. Schneider; Scott M. Smith; Erica Sodergren; Amanda F. Svatek; Teresa R. Utterback; Selina Vattathil; Wesley Warren; Courtney Sherell White; Asif T. Chinwalla; Yucheng Feng; Aaron L. Halpern; La Deana W. Hillier; Xiaoqiu Huang; Pat Minx; Joanne O. Nelson; Kymbertie H. Pepin; Xiang Qin; Granger G. Sutton; Eli Venter; Brian P. Walenz; John W. Wallis; Kim C. Worley; Shiaw Pyng Yang; Steven M. Jones; Marco A. Marra; Mariano Rocchi; Jacqueline E. Schein; Robert Baertsch; Laura Clarke; Miklós Csürös; Jarret Glasscock; R. Alan Harris; Paul Havlak; Andrew R. Jackson; Huaiyang Jiang; Yue Liu; David N. Messina; Yufeng Shen; Henry Xing Zhi Song; Todd Wylie; Lan Zhang; Ewan Birney; Kyudong Han; Miriam K. Konkel; Jungnam Lee; Arian F.A. Smit; Brygg Ullmer; Hui Wang; Jinchuan Xing; Richard Burhans; Ze Cheng; John E. Karro; Jian Ma; Brian Raney; Xinwei She; Michael J. Cox; Jeffery P. Demuth; Laura J. Dumas; Sang Gook Han; Janet Hopkins; Anis Karimpour-Fard; Young H. Kim; Jonathan R. Pollack; Tomas Vinar; Charles Addo-Quaye; Jeremiah Degenhardt; Alexandra Denby; Melissa J. Hubisz; Amit Indap; Carolin Kosiol; Bruce T. Lahn; Heather A. Lawson; Alison Marklein; Rasmus Nielsen; Eric J. Vallender; Andrew G. Clark; Betsy Ferguson; Ryan D. Hernandez; Kashif Hirani; Hildegard Kehrer-Sawatzki; Jessica Kolb; Shobha Patil; Ling Ling Pu; Yanru Ren; David Glenn Smith; David A. Wheeler; Ian Schenck; Edward V. Ball; Rui Chen; David N. Cooper; Belinda Giardine; Fan Hsu; W. James Kent; Arthur Lesk; David L. Nelson; William E. O'Brien; Kay Prüfer; Peter D. Stenson; James C. Wallace; Hui Ke; Xiao Ming Liu; Peng Wang; Andy Peng Xiang; Fan Yang; Gait P. Barber; David Haussler; Donna Karolchik; Andy D. Kern; Robert M. Kuhn; Kayla E. Smith; Ann S. Zwieg

doi:10.1126/science.1139247

Evolutionary and biomedical insights from the rhesus macaque genome

Richard A. Gibbs, Jeffrey Rogers, Michael G. Katze, Roger Bumgarner, George M. Weinstock, Elaine R. Mardis, Karin A. Remington, Robert L. Strausberg, J. Craig Venter, Richard K. Wilson, Mark A. Batzer, Carlos D. Bustamante, Evan E. Eichler, Matthew W. Hahn, Ross C. Hardison, Kateryna D. Makova, Webb Miller, Aleksandar Milosavljevic, Robert E. Palermo, Adam SiepelJames M. Sikela, Tony Attaway, Stephanie Bell, Kelly E. Bernard, Christian J. Buhay, Mimi N. Chandrabose, Marvin Dao, Clay Davis, Kimberly D. Delehaunty, Yan Ding, Huyen H. Dinh, Shannon Dugan-Rocha, Lucinda A. Fulton, Ramatu Ayiesha Gabisi, Toni T. Garner, Jennifer Godfrey, Alicia C. Hawes, Judith Hernandez, Sandra Hines, Michael Holder, Jennifer Hume, Shalini N. Jhangiani, Vandita Joshi, Ziad Mohid Khan, Ewen F. Kirkness, Andrew Cree, R. Gerald Fowler, Sandra Lee, Lora R. Lewis, Zhangwan Li, Yih Shin Liu, Stephanie M. Moore, Donna Muzny, Lynne V. Nazareth, Ngoc Ngo Dinh, Geoffrey O. Okwuonu, Grace Pai, David Parker, Heidie A. Paul, Cynthia Pfannkoch, Craig S. Pohl, Yu Hui Rogers, San Juana Ruiz, Aniko Sabo, Jireh Santibanez, Brian W. Schneider, Scott M. Smith, Erica Sodergren, Amanda F. Svatek, Teresa R. Utterback, Selina Vattathil, Wesley Warren, Courtney Sherell White, Asif T. Chinwalla, Yucheng Feng, Aaron L. Halpern, La Deana W. Hillier, Xiaoqiu Huang, Pat Minx, Joanne O. Nelson, Kymbertie H. Pepin, Xiang Qin, Granger G. Sutton, Eli Venter, Brian P. Walenz, John W. Wallis, Kim C. Worley, Shiaw Pyng Yang, Steven M. Jones, Marco A. Marra, Mariano Rocchi, Jacqueline E. Schein, Robert Baertsch, Laura Clarke, Miklós Csürös, Jarret Glasscock, R. Alan Harris, Paul Havlak, Andrew R. Jackson, Huaiyang Jiang, Yue Liu, David N. Messina, Yufeng Shen, Henry Xing Zhi Song, Todd Wylie, Lan Zhang, Ewan Birney, Kyudong Han, Miriam K. Konkel, Jungnam Lee, Arian F.A. Smit, Brygg Ullmer, Hui Wang, Jinchuan Xing, Richard Burhans, Ze Cheng, John E. Karro, Jian Ma, Brian Raney, Xinwei She, Michael J. Cox, Jeffery P. Demuth, Laura J. Dumas, Sang Gook Han, Janet Hopkins, Anis Karimpour-Fard, Young H. Kim, Jonathan R. Pollack, Tomas Vinar, Charles Addo-Quaye, Jeremiah Degenhardt, Alexandra Denby, Melissa J. Hubisz, Amit Indap, Carolin Kosiol, Bruce T. Lahn, Heather A. Lawson, Alison Marklein, Rasmus Nielsen, Eric J. Vallender, Andrew G. Clark, Betsy Ferguson, Ryan D. Hernandez, Kashif Hirani, Hildegard Kehrer-Sawatzki, Jessica Kolb, Shobha Patil, Ling Ling Pu, Yanru Ren, David Glenn Smith, David A. Wheeler, Ian Schenck, Edward V. Ball, Rui Chen, David N. Cooper, Belinda Giardine, Fan Hsu, W. James Kent, Arthur Lesk, David L. Nelson, William E. O'Brien, Kay Prüfer, Peter D. Stenson, James C. Wallace, Hui Ke, Xiao Ming Liu, Peng Wang, Andy Peng Xiang, Fan Yang, Gait P. Barber, David Haussler, Donna Karolchik, Andy D. Kern, Robert M. Kuhn, Kayla E. Smith, Ann S. Zwieg

Oregon National Primate Research Center

Research output: Contribution to journal › Review article › peer-review

1081 Scopus citations

Abstract

The rhesus macaque (Macaca mulatta) is an abundant primate species that diverged from the ancestors of Homo sapiens about 25 million years ago. Because they are genetically and physiologically similar to humans, rhesus monkeys are the most widely used nonhuman primate in basic and applied biomedical research. We determined the genome sequence of an Indian-origin Macaca mulatta female and compared the data with chimpanzees and humans to reveal the structure of ancestral primate genomes and to identify evidence for positive selection and lineage-specific expansions and contractions of gene families. A comparison of sequences from individual animals was used to investigate their underlying genetic diversity. The complete description of the macaque genome blueprint enhances the utility of this animal model for biomedical research and improves our understanding of the basic biology of the species.

Original language	English (US)
Pages (from-to)	222-234
Number of pages	13
Journal	Science
Volume	316
Issue number	5822
DOIs	https://doi.org/10.1126/science.1139247
State	Published - Apr 13 2007

ASJC Scopus subject areas

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10.1126/science.1139247

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Gibbs, R. A., Rogers, J., Katze, M. G., Bumgarner, R., Weinstock, G. M., Mardis, E. R., Remington, K. A., Strausberg, R. L., Venter, J. C., Wilson, R. K., Batzer, M. A., Bustamante, C. D., Eichler, E. E., Hahn, M. W., Hardison, R. C., Makova, K. D., Miller, W., Milosavljevic, A., Palermo, R. E., ... Zwieg, A. S. (2007). Evolutionary and biomedical insights from the rhesus macaque genome. Science, 316(5822), 222-234. https://doi.org/10.1126/science.1139247

Gibbs, RA, Rogers, J, Katze, MG, Bumgarner, R, Weinstock, GM, Mardis, ER, Remington, KA, Strausberg, RL, Venter, JC, Wilson, RK, Batzer, MA, Bustamante, CD, Eichler, EE, Hahn, MW, Hardison, RC, Makova, KD, Miller, W, Milosavljevic, A, Palermo, RE, Siepel, A, Sikela, JM, Attaway, T, Bell, S, Bernard, KE, Buhay, CJ, Chandrabose, MN, Dao, M, Davis, C, Delehaunty, KD, Ding, Y, Dinh, HH, Dugan-Rocha, S, Fulton, LA, Gabisi, RA, Garner, TT, Godfrey, J, Hawes, AC, Hernandez, J, Hines, S, Holder, M, Hume, J, Jhangiani, SN, Joshi, V, Khan, ZM, Kirkness, EF, Cree, A, Fowler, RG, Lee, S, Lewis, LR, Li, Z, Liu, YS, Moore, SM, Muzny, D, Nazareth, LV, Dinh, NN, Okwuonu, GO, Pai, G, Parker, D, Paul, HA, Pfannkoch, C, Pohl, CS, Rogers, YH, Ruiz, SJ, Sabo, A, Santibanez, J, Schneider, BW, Smith, SM, Sodergren, E, Svatek, AF, Utterback, TR, Vattathil, S, Warren, W, White, CS, Chinwalla, AT, Feng, Y, Halpern, AL, Hillier, LDW, Huang, X, Minx, P, Nelson, JO, Pepin, KH, Qin, X, Sutton, GG, Venter, E, Walenz, BP, Wallis, JW, Worley, KC, Yang, SP, Jones, SM, Marra, MA, Rocchi, M, Schein, JE, Baertsch, R, Clarke, L, Csürös, M, Glasscock, J, Harris, RA, Havlak, P, Jackson, AR, Jiang, H, Liu, Y, Messina, DN, Shen, Y, Song, HXZ, Wylie, T, Zhang, L, Birney, E, Han, K, Konkel, MK, Lee, J, Smit, AFA, Ullmer, B, Wang, H, Xing, J, Burhans, R, Cheng, Z, Karro, JE, Ma, J, Raney, B, She, X, Cox, MJ, Demuth, JP, Dumas, LJ, Han, SG, Hopkins, J, Karimpour-Fard, A, Kim, YH, Pollack, JR, Vinar, T, Addo-Quaye, C, Degenhardt, J, Denby, A, Hubisz, MJ, Indap, A, Kosiol, C, Lahn, BT, Lawson, HA, Marklein, A, Nielsen, R, Vallender, EJ, Clark, AG, Ferguson, B, Hernandez, RD, Hirani, K, Kehrer-Sawatzki, H, Kolb, J, Patil, S, Pu, LL, Ren, Y, Smith, DG, Wheeler, DA, Schenck, I, Ball, EV, Chen, R, Cooper, DN, Giardine, B, Hsu, F, Kent, WJ, Lesk, A, Nelson, DL, O'Brien, WE, Prüfer, K, Stenson, PD, Wallace, JC, Ke, H, Liu, XM, Wang, P, Xiang, AP, Yang, F, Barber, GP, Haussler, D, Karolchik, D, Kern, AD, Kuhn, RM, Smith, KE & Zwieg, AS 2007, 'Evolutionary and biomedical insights from the rhesus macaque genome', Science, vol. 316, no. 5822, pp. 222-234. https://doi.org/10.1126/science.1139247

@article{d01033c73998481d9bc32f041061998c,

title = "Evolutionary and biomedical insights from the rhesus macaque genome",

abstract = "The rhesus macaque (Macaca mulatta) is an abundant primate species that diverged from the ancestors of Homo sapiens about 25 million years ago. Because they are genetically and physiologically similar to humans, rhesus monkeys are the most widely used nonhuman primate in basic and applied biomedical research. We determined the genome sequence of an Indian-origin Macaca mulatta female and compared the data with chimpanzees and humans to reveal the structure of ancestral primate genomes and to identify evidence for positive selection and lineage-specific expansions and contractions of gene families. A comparison of sequences from individual animals was used to investigate their underlying genetic diversity. The complete description of the macaque genome blueprint enhances the utility of this animal model for biomedical research and improves our understanding of the basic biology of the species.",

author = "Gibbs, {Richard A.} and Jeffrey Rogers and Katze, {Michael G.} and Roger Bumgarner and Weinstock, {George M.} and Mardis, {Elaine R.} and Remington, {Karin A.} and Strausberg, {Robert L.} and Venter, {J. Craig} and Wilson, {Richard K.} and Batzer, {Mark A.} and Bustamante, {Carlos D.} and Eichler, {Evan E.} and Hahn, {Matthew W.} and Hardison, {Ross C.} and Makova, {Kateryna D.} and Webb Miller and Aleksandar Milosavljevic and Palermo, {Robert E.} and Adam Siepel and Sikela, {James M.} and Tony Attaway and Stephanie Bell and Bernard, {Kelly E.} and Buhay, {Christian J.} and Chandrabose, {Mimi N.} and Marvin Dao and Clay Davis and Delehaunty, {Kimberly D.} and Yan Ding and Dinh, {Huyen H.} and Shannon Dugan-Rocha and Fulton, {Lucinda A.} and Gabisi, {Ramatu Ayiesha} and Garner, {Toni T.} and Jennifer Godfrey and Hawes, {Alicia C.} and Judith Hernandez and Sandra Hines and Michael Holder and Jennifer Hume and Jhangiani, {Shalini N.} and Vandita Joshi and Khan, {Ziad Mohid} and Kirkness, {Ewen F.} and Andrew Cree and Fowler, {R. Gerald} and Sandra Lee and Lewis, {Lora R.} and Zhangwan Li and Liu, {Yih Shin} and Moore, {Stephanie M.} and Donna Muzny and Nazareth, {Lynne V.} and Dinh, {Ngoc Ngo} and Okwuonu, {Geoffrey O.} and Grace Pai and David Parker and Paul, {Heidie A.} and Cynthia Pfannkoch and Pohl, {Craig S.} and Rogers, {Yu Hui} and Ruiz, {San Juana} and Aniko Sabo and Jireh Santibanez and Schneider, {Brian W.} and Smith, {Scott M.} and Erica Sodergren and Svatek, {Amanda F.} and Utterback, {Teresa R.} and Selina Vattathil and Wesley Warren and White, {Courtney Sherell} and Chinwalla, {Asif T.} and Yucheng Feng and Halpern, {Aaron L.} and Hillier, {La Deana W.} and Xiaoqiu Huang and Pat Minx and Nelson, {Joanne O.} and Pepin, {Kymbertie H.} and Xiang Qin and Sutton, {Granger G.} and Eli Venter and Walenz, {Brian P.} and Wallis, {John W.} and Worley, {Kim C.} and Yang, {Shiaw Pyng} and Jones, {Steven M.} and Marra, {Marco A.} and Mariano Rocchi and Schein, {Jacqueline E.} and Robert Baertsch and Laura Clarke and Mikl{\'o}s Cs{\"u}r{\"o}s and Jarret Glasscock and Harris, {R. Alan} and Paul Havlak and Jackson, {Andrew R.} and Huaiyang Jiang and Yue Liu and Messina, {David N.} and Yufeng Shen and Song, {Henry Xing Zhi} and Todd Wylie and Lan Zhang and Ewan Birney and Kyudong Han and Konkel, {Miriam K.} and Jungnam Lee and Smit, {Arian F.A.} and Brygg Ullmer and Hui Wang and Jinchuan Xing and Richard Burhans and Ze Cheng and Karro, {John E.} and Jian Ma and Brian Raney and Xinwei She and Cox, {Michael J.} and Demuth, {Jeffery P.} and Dumas, {Laura J.} and Han, {Sang Gook} and Janet Hopkins and Anis Karimpour-Fard and Kim, {Young H.} and Pollack, {Jonathan R.} and Tomas Vinar and Charles Addo-Quaye and Jeremiah Degenhardt and Alexandra Denby and Hubisz, {Melissa J.} and Amit Indap and Carolin Kosiol and Lahn, {Bruce T.} and Lawson, {Heather A.} and Alison Marklein and Rasmus Nielsen and Vallender, {Eric J.} and Clark, {Andrew G.} and Betsy Ferguson and Hernandez, {Ryan D.} and Kashif Hirani and Hildegard Kehrer-Sawatzki and Jessica Kolb and Shobha Patil and Pu, {Ling Ling} and Yanru Ren and Smith, {David Glenn} and Wheeler, {David A.} and Ian Schenck and Ball, {Edward V.} and Rui Chen and Cooper, {David N.} and Belinda Giardine and Fan Hsu and Kent, {W. James} and Arthur Lesk and Nelson, {David L.} and O'Brien, {William E.} and Kay Pr{\"u}fer and Stenson, {Peter D.} and Wallace, {James C.} and Hui Ke and Liu, {Xiao Ming} and Peng Wang and Xiang, {Andy Peng} and Fan Yang and Barber, {Gait P.} and David Haussler and Donna Karolchik and Kern, {Andy D.} and Kuhn, {Robert M.} and Smith, {Kayla E.} and Zwieg, {Ann S.}",

year = "2007",

month = apr,

day = "13",

doi = "10.1126/science.1139247",

language = "English (US)",

volume = "316",

pages = "222--234",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "5822",

}

TY - JOUR

T1 - Evolutionary and biomedical insights from the rhesus macaque genome

AU - Gibbs, Richard A.

AU - Rogers, Jeffrey

AU - Katze, Michael G.

AU - Bumgarner, Roger

AU - Weinstock, George M.

AU - Mardis, Elaine R.

AU - Remington, Karin A.

AU - Strausberg, Robert L.

AU - Venter, J. Craig

AU - Wilson, Richard K.

AU - Batzer, Mark A.

AU - Bustamante, Carlos D.

AU - Eichler, Evan E.

AU - Hahn, Matthew W.

AU - Hardison, Ross C.

AU - Makova, Kateryna D.

AU - Miller, Webb

AU - Milosavljevic, Aleksandar

AU - Palermo, Robert E.

AU - Siepel, Adam

AU - Sikela, James M.

AU - Attaway, Tony

AU - Bell, Stephanie

AU - Bernard, Kelly E.

AU - Buhay, Christian J.

AU - Chandrabose, Mimi N.

AU - Dao, Marvin

AU - Davis, Clay

AU - Delehaunty, Kimberly D.

AU - Ding, Yan

AU - Dinh, Huyen H.

AU - Dugan-Rocha, Shannon

AU - Fulton, Lucinda A.

AU - Gabisi, Ramatu Ayiesha

AU - Garner, Toni T.

AU - Godfrey, Jennifer

AU - Hawes, Alicia C.

AU - Hernandez, Judith

AU - Hines, Sandra

AU - Holder, Michael

AU - Hume, Jennifer

AU - Jhangiani, Shalini N.

AU - Joshi, Vandita

AU - Khan, Ziad Mohid

AU - Kirkness, Ewen F.

AU - Cree, Andrew

AU - Fowler, R. Gerald

AU - Lee, Sandra

AU - Lewis, Lora R.

AU - Li, Zhangwan

AU - Liu, Yih Shin

AU - Moore, Stephanie M.

AU - Muzny, Donna

AU - Nazareth, Lynne V.

AU - Dinh, Ngoc Ngo

AU - Okwuonu, Geoffrey O.

AU - Pai, Grace

AU - Parker, David

AU - Paul, Heidie A.

AU - Pfannkoch, Cynthia

AU - Pohl, Craig S.

AU - Rogers, Yu Hui

AU - Ruiz, San Juana

AU - Sabo, Aniko

AU - Santibanez, Jireh

AU - Schneider, Brian W.

AU - Smith, Scott M.

AU - Sodergren, Erica

AU - Svatek, Amanda F.

AU - Utterback, Teresa R.

AU - Vattathil, Selina

AU - Warren, Wesley

AU - White, Courtney Sherell

AU - Chinwalla, Asif T.

AU - Feng, Yucheng

AU - Halpern, Aaron L.

AU - Hillier, La Deana W.

AU - Huang, Xiaoqiu

AU - Minx, Pat

AU - Nelson, Joanne O.

AU - Pepin, Kymbertie H.

AU - Qin, Xiang

AU - Sutton, Granger G.

AU - Venter, Eli

AU - Walenz, Brian P.

AU - Wallis, John W.

AU - Worley, Kim C.

AU - Yang, Shiaw Pyng

AU - Jones, Steven M.

AU - Marra, Marco A.

AU - Rocchi, Mariano

AU - Schein, Jacqueline E.

AU - Baertsch, Robert

AU - Clarke, Laura

AU - Csürös, Miklós

AU - Glasscock, Jarret

AU - Harris, R. Alan

AU - Havlak, Paul

AU - Jackson, Andrew R.

AU - Jiang, Huaiyang

AU - Liu, Yue

AU - Messina, David N.

AU - Shen, Yufeng

AU - Song, Henry Xing Zhi

AU - Wylie, Todd

AU - Zhang, Lan

AU - Birney, Ewan

AU - Han, Kyudong

AU - Konkel, Miriam K.

AU - Lee, Jungnam

AU - Smit, Arian F.A.

AU - Ullmer, Brygg

AU - Wang, Hui

AU - Xing, Jinchuan

AU - Burhans, Richard

AU - Cheng, Ze

AU - Karro, John E.

AU - Ma, Jian

AU - Raney, Brian

AU - She, Xinwei

AU - Cox, Michael J.

AU - Demuth, Jeffery P.

AU - Dumas, Laura J.

AU - Han, Sang Gook

AU - Hopkins, Janet

AU - Karimpour-Fard, Anis

AU - Kim, Young H.

AU - Pollack, Jonathan R.

AU - Vinar, Tomas

AU - Addo-Quaye, Charles

AU - Degenhardt, Jeremiah

AU - Denby, Alexandra

AU - Hubisz, Melissa J.

AU - Indap, Amit

AU - Kosiol, Carolin

AU - Lahn, Bruce T.

AU - Lawson, Heather A.

AU - Marklein, Alison

AU - Nielsen, Rasmus

AU - Vallender, Eric J.

AU - Clark, Andrew G.

AU - Ferguson, Betsy

AU - Hernandez, Ryan D.

AU - Hirani, Kashif

AU - Kehrer-Sawatzki, Hildegard

AU - Kolb, Jessica

AU - Patil, Shobha

AU - Pu, Ling Ling

AU - Ren, Yanru

AU - Smith, David Glenn

AU - Wheeler, David A.

AU - Schenck, Ian

AU - Ball, Edward V.

AU - Chen, Rui

AU - Cooper, David N.

AU - Giardine, Belinda

AU - Hsu, Fan

AU - Kent, W. James

AU - Lesk, Arthur

AU - Nelson, David L.

AU - O'Brien, William E.

AU - Prüfer, Kay

AU - Stenson, Peter D.

AU - Wallace, James C.

AU - Ke, Hui

AU - Liu, Xiao Ming

AU - Wang, Peng

AU - Xiang, Andy Peng

AU - Yang, Fan

AU - Barber, Gait P.

AU - Haussler, David

AU - Karolchik, Donna

AU - Kern, Andy D.

AU - Kuhn, Robert M.

AU - Smith, Kayla E.

AU - Zwieg, Ann S.

PY - 2007/4/13

Y1 - 2007/4/13

N2 - The rhesus macaque (Macaca mulatta) is an abundant primate species that diverged from the ancestors of Homo sapiens about 25 million years ago. Because they are genetically and physiologically similar to humans, rhesus monkeys are the most widely used nonhuman primate in basic and applied biomedical research. We determined the genome sequence of an Indian-origin Macaca mulatta female and compared the data with chimpanzees and humans to reveal the structure of ancestral primate genomes and to identify evidence for positive selection and lineage-specific expansions and contractions of gene families. A comparison of sequences from individual animals was used to investigate their underlying genetic diversity. The complete description of the macaque genome blueprint enhances the utility of this animal model for biomedical research and improves our understanding of the basic biology of the species.

AB - The rhesus macaque (Macaca mulatta) is an abundant primate species that diverged from the ancestors of Homo sapiens about 25 million years ago. Because they are genetically and physiologically similar to humans, rhesus monkeys are the most widely used nonhuman primate in basic and applied biomedical research. We determined the genome sequence of an Indian-origin Macaca mulatta female and compared the data with chimpanzees and humans to reveal the structure of ancestral primate genomes and to identify evidence for positive selection and lineage-specific expansions and contractions of gene families. A comparison of sequences from individual animals was used to investigate their underlying genetic diversity. The complete description of the macaque genome blueprint enhances the utility of this animal model for biomedical research and improves our understanding of the basic biology of the species.

UR - http://www.scopus.com/inward/record.url?scp=34247352040&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34247352040&partnerID=8YFLogxK

U2 - 10.1126/science.1139247

DO - 10.1126/science.1139247

M3 - Review article

C2 - 17431167

AN - SCOPUS:34247352040

SN - 0036-8075

VL - 316

SP - 222

EP - 234

JO - Science

JF - Science

IS - 5822

ER -

Evolutionary and biomedical insights from the rhesus macaque genome

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