Evidence that low-level viremias during effective highly active antiretroviral therapy result from two processes: Expression of archival virus and replication of virus

Nicole H. Tobin, Gerald H. Learn, Sarah E. Holte, Yang Wang, Ann J. Melvin, Jennifer L. McKernan, Diane M. Pawluk, Kathleen M. Mohan, Paul Lewis, James I. Mullins, Lisa M. Frenkel

Research output: Contribution to journalArticle

138 Citations (Scopus)

Abstract

Episodes of low-level viremia (LLV), with plasma human immunodeficiency virus type 1 (HIV-1) RNA levels ranging from 50 to 400 copies (c)/ml, occur commonly during highly active antiretroviral therapy (HAART). LLV has been associated with virologic failure of HAART in some studies, while in others LLV did not appear to affect the clinical outcome. To understand the processes leading to LLV, genetic analyses were used to determine whether plasma virions emanated from archived or from newly evolved viral genomes. Episodes of LLV (plasma HIV-1 RNA, 50 to 379 [median, 77] c/ml) were detected in 21/37 (57%) HIV-1-infected children with median plasma HIV-1 RNA levels of

Original languageEnglish (US)
Pages (from-to)9625-9634
Number of pages10
JournalJournal of Virology
Volume79
Issue number15
DOIs
StatePublished - Aug 2005

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Viremia
viremia
Highly Active Antiretroviral Therapy
Virus Replication
virus replication
Human immunodeficiency virus 1
HIV-1
Viruses
viruses
therapeutics
RNA
Viral Genome
virion
Virion
genome

ASJC Scopus subject areas

  • Immunology

Cite this

Evidence that low-level viremias during effective highly active antiretroviral therapy result from two processes : Expression of archival virus and replication of virus. / Tobin, Nicole H.; Learn, Gerald H.; Holte, Sarah E.; Wang, Yang; Melvin, Ann J.; McKernan, Jennifer L.; Pawluk, Diane M.; Mohan, Kathleen M.; Lewis, Paul; Mullins, James I.; Frenkel, Lisa M.

In: Journal of Virology, Vol. 79, No. 15, 08.2005, p. 9625-9634.

Research output: Contribution to journalArticle

Tobin, NH, Learn, GH, Holte, SE, Wang, Y, Melvin, AJ, McKernan, JL, Pawluk, DM, Mohan, KM, Lewis, P, Mullins, JI & Frenkel, LM 2005, 'Evidence that low-level viremias during effective highly active antiretroviral therapy result from two processes: Expression of archival virus and replication of virus', Journal of Virology, vol. 79, no. 15, pp. 9625-9634. https://doi.org/10.1128/JVI.79.15.9625-9634.2005
Tobin, Nicole H. ; Learn, Gerald H. ; Holte, Sarah E. ; Wang, Yang ; Melvin, Ann J. ; McKernan, Jennifer L. ; Pawluk, Diane M. ; Mohan, Kathleen M. ; Lewis, Paul ; Mullins, James I. ; Frenkel, Lisa M. / Evidence that low-level viremias during effective highly active antiretroviral therapy result from two processes : Expression of archival virus and replication of virus. In: Journal of Virology. 2005 ; Vol. 79, No. 15. pp. 9625-9634.
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