Evidence for genetic contamination of inbred Buffalo rats (RT-1b) obtained from a commercial vendor

Richard E. Jones, Andrew Weinberg, Dennis Bourdette

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Inbred Buffalo rats (RT-1b) have been used in studies of experimental autoimmune encephalomyelitis and autoimmune thyroiditis. Since our studies, and those of others, have relied on the genetic purity of inbred Buffalo rats, we chose to test these animals for expression of strain-dependent, allotype-specific variants of CD45 (leukocyte common antigen, LCA) using the monoclonal antibodies RT7.1 and RT7.2. The goal of this study was to confirm the genetic purity and to verify the inbred status of Buffalo rats obtained from a commericial source.

Original languageEnglish (US)
Pages (from-to)215-218
Number of pages4
JournalJournal of Neuroimmunology
Volume52
Issue number2
DOIs
StatePublished - Jul 1994

Keywords

  • Buffalo rats
  • Demyelination
  • Experimental autoimmune encephalomyelitis
  • Genetic purity
  • Inbred strain

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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