Evidence for genetic contamination of inbred Buffalo rats (RT-1b) obtained from a commercial vendor

Richard E. Jones; Andrew Weinberg; Dennis Bourdette

doi:10.1016/0165-5728(94)90115-5

Evidence for genetic contamination of inbred Buffalo rats (RT-1^b) obtained from a commercial vendor

Richard E. Jones, Andrew Weinberg, Dennis Bourdette

Neurology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Inbred Buffalo rats (RT-1^b) have been used in studies of experimental autoimmune encephalomyelitis and autoimmune thyroiditis. Since our studies, and those of others, have relied on the genetic purity of inbred Buffalo rats, we chose to test these animals for expression of strain-dependent, allotype-specific variants of CD45 (leukocyte common antigen, LCA) using the monoclonal antibodies RT7.1 and RT7.2. The goal of this study was to confirm the genetic purity and to verify the inbred status of Buffalo rats obtained from a commericial source.

Original language	English (US)
Pages (from-to)	215-218
Number of pages	4
Journal	Journal of Neuroimmunology
Volume	52
Issue number	2
DOIs	https://doi.org/10.1016/0165-5728(94)90115-5
State	Published - Jul 1994

Keywords

Buffalo rats
Demyelination
Experimental autoimmune encephalomyelitis
Genetic purity
Inbred strain

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

Access to Document

10.1016/0165-5728(94)90115-5

Cite this

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title = "Evidence for genetic contamination of inbred Buffalo rats (RT-1b) obtained from a commercial vendor",

abstract = "Inbred Buffalo rats (RT-1b) have been used in studies of experimental autoimmune encephalomyelitis and autoimmune thyroiditis. Since our studies, and those of others, have relied on the genetic purity of inbred Buffalo rats, we chose to test these animals for expression of strain-dependent, allotype-specific variants of CD45 (leukocyte common antigen, LCA) using the monoclonal antibodies RT7.1 and RT7.2. The goal of this study was to confirm the genetic purity and to verify the inbred status of Buffalo rats obtained from a commericial source.",

keywords = "Buffalo rats, Demyelination, Experimental autoimmune encephalomyelitis, Genetic purity, Inbred strain",

author = "Jones, {Richard E.} and Andrew Weinberg and Dennis Bourdette",

note = "Funding Information: Supported by the US Department of Veterans Affairs and the National Multiple Sclerosis Society (RG2521).",

year = "1994",

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T1 - Evidence for genetic contamination of inbred Buffalo rats (RT-1b) obtained from a commercial vendor

AU - Jones, Richard E.

AU - Weinberg, Andrew

AU - Bourdette, Dennis

N1 - Funding Information: Supported by the US Department of Veterans Affairs and the National Multiple Sclerosis Society (RG2521).

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N2 - Inbred Buffalo rats (RT-1b) have been used in studies of experimental autoimmune encephalomyelitis and autoimmune thyroiditis. Since our studies, and those of others, have relied on the genetic purity of inbred Buffalo rats, we chose to test these animals for expression of strain-dependent, allotype-specific variants of CD45 (leukocyte common antigen, LCA) using the monoclonal antibodies RT7.1 and RT7.2. The goal of this study was to confirm the genetic purity and to verify the inbred status of Buffalo rats obtained from a commericial source.

AB - Inbred Buffalo rats (RT-1b) have been used in studies of experimental autoimmune encephalomyelitis and autoimmune thyroiditis. Since our studies, and those of others, have relied on the genetic purity of inbred Buffalo rats, we chose to test these animals for expression of strain-dependent, allotype-specific variants of CD45 (leukocyte common antigen, LCA) using the monoclonal antibodies RT7.1 and RT7.2. The goal of this study was to confirm the genetic purity and to verify the inbred status of Buffalo rats obtained from a commericial source.

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KW - Genetic purity

KW - Inbred strain

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