Evaluation of the Cardiac Effects of Doxorubicin by Serial Echocardiography

John J. Hutter, David Sahn, Yvonne Carnahan

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Serial echocardiographic studies were performed on 48 children who received chemotherapy with doxorubicin hydrochloride For the group as a whole, no correlation could be made between the cumulative dose of doxorubicin administered and left ventricular systolic function as measured by the fractional shortening of the left ventricle (Δs). Two asymptomatic patients, however, demonstrated depressed Δs and abnormal results from radionuclide studies at cumulative doxorubicin doses of less than 430 mg/sq m. Differentiation of the echo-derived curve of left ventricular minor axis dimension indicated that these two patients had abnormalities in both diastolic and systolic function. Good correlation was demonstrated between echocardiographic and radionuclide studies in eight patients, including the two with depressed function. Inherent variability limits the sensitivity of echocardiographic functional studies, but serial studies are helpful in the evaluation of cardiac function in children who receive doxorubicin.

Original languageEnglish (US)
Pages (from-to)653-657
Number of pages5
JournalAmerican Journal of Diseases of Children
Volume135
Issue number7
DOIs
StatePublished - 1981
Externally publishedYes

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Doxorubicin
Echocardiography
Radioisotopes
Left Ventricular Function
Heart Ventricles
Drug Therapy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Evaluation of the Cardiac Effects of Doxorubicin by Serial Echocardiography. / Hutter, John J.; Sahn, David; Carnahan, Yvonne.

In: American Journal of Diseases of Children, Vol. 135, No. 7, 1981, p. 653-657.

Research output: Contribution to journalArticle

Hutter, John J. ; Sahn, David ; Carnahan, Yvonne. / Evaluation of the Cardiac Effects of Doxorubicin by Serial Echocardiography. In: American Journal of Diseases of Children. 1981 ; Vol. 135, No. 7. pp. 653-657.
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