Abstract
Serial echocardiographic studies were performed on 48 children who received chemotherapy with doxorubicin hydrochloride For the group as a whole, no correlation could be made between the cumulative dose of doxorubicin administered and left ventricular systolic function as measured by the fractional shortening of the left ventricle (Δs). Two asymptomatic patients, however, demonstrated depressed Δs and abnormal results from radionuclide studies at cumulative doxorubicin doses of less than 430 mg/sq m. Differentiation of the echo-derived curve of left ventricular minor axis dimension indicated that these two patients had abnormalities in both diastolic and systolic function. Good correlation was demonstrated between echocardiographic and radionuclide studies in eight patients, including the two with depressed function. Inherent variability limits the sensitivity of echocardiographic functional studies, but serial studies are helpful in the evaluation of cardiac function in children who receive doxorubicin.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 653-657 |
| Number of pages | 5 |
| Journal | American Journal of Diseases of Children |
| Volume | 135 |
| Issue number | 7 |
| DOIs | |
| State | Published - 1981 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
Evaluation of the Cardiac Effects of Doxorubicin by Serial Echocardiography. / Hutter, John J.; Sahn, David; Carnahan, Yvonne.
In: American Journal of Diseases of Children, Vol. 135, No. 7, 1981, p. 653-657.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Evaluation of the Cardiac Effects of Doxorubicin by Serial Echocardiography
AU - Hutter, John J.
AU - Sahn, David
AU - Carnahan, Yvonne
PY - 1981
Y1 - 1981
N2 - Serial echocardiographic studies were performed on 48 children who received chemotherapy with doxorubicin hydrochloride For the group as a whole, no correlation could be made between the cumulative dose of doxorubicin administered and left ventricular systolic function as measured by the fractional shortening of the left ventricle (Δs). Two asymptomatic patients, however, demonstrated depressed Δs and abnormal results from radionuclide studies at cumulative doxorubicin doses of less than 430 mg/sq m. Differentiation of the echo-derived curve of left ventricular minor axis dimension indicated that these two patients had abnormalities in both diastolic and systolic function. Good correlation was demonstrated between echocardiographic and radionuclide studies in eight patients, including the two with depressed function. Inherent variability limits the sensitivity of echocardiographic functional studies, but serial studies are helpful in the evaluation of cardiac function in children who receive doxorubicin.
AB - Serial echocardiographic studies were performed on 48 children who received chemotherapy with doxorubicin hydrochloride For the group as a whole, no correlation could be made between the cumulative dose of doxorubicin administered and left ventricular systolic function as measured by the fractional shortening of the left ventricle (Δs). Two asymptomatic patients, however, demonstrated depressed Δs and abnormal results from radionuclide studies at cumulative doxorubicin doses of less than 430 mg/sq m. Differentiation of the echo-derived curve of left ventricular minor axis dimension indicated that these two patients had abnormalities in both diastolic and systolic function. Good correlation was demonstrated between echocardiographic and radionuclide studies in eight patients, including the two with depressed function. Inherent variability limits the sensitivity of echocardiographic functional studies, but serial studies are helpful in the evaluation of cardiac function in children who receive doxorubicin.
UR - http://www.scopus.com/inward/record.url?scp=0019485609&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019485609&partnerID=8YFLogxK
U2 - 10.1001/archpedi.1981.02130310057019
DO - 10.1001/archpedi.1981.02130310057019
M3 - Article
C2 - 7246495
AN - SCOPUS:0019485609
VL - 135
SP - 653
EP - 657
JO - JAMA Pediatrics
JF - JAMA Pediatrics
SN - 2168-6203
IS - 7
ER -