Evaluation of plasma homocysteine and risk of age-related macular degeneration

Johanna M. Seddon, Gary Gensler, Michael Klein, Roy C. Milton

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

PURPOSE: To assess the relationship between plasma levels of homocysteine and age-related macular degeneration (AMD). DESIGN: Cross-sectional, case-control study. METHODS: Fasting plasma homocysteine levels were measured at two centers in 934 individuals who were participating in an ancillary study of the Age-Related Eye Disease Study. There were 547 cases and 387 control subjects, who were determined by fundus photography. Conditional logistic regression analyses were conducted to assess the association of homocysteine with AMD. RESULTS: Median values of homocysteine were higher among advanced AMD cases (9.51 mmol/l) compared with persons with no AMD (8.81 mmol/l; P = .01). Values of >12 mmol/l vs ≤12 mmol/l were also associated with an increased risk of AMD (P = .023), when controlled for other covariates. CONCLUSION: Results are consistent with a possible small, independent association between higher homocysteine levels and AMD. Homocysteine may be a modifiable risk factor for AMD.

Original languageEnglish (US)
Pages (from-to)201-203
Number of pages3
JournalAmerican Journal of Ophthalmology
Volume141
Issue number1
DOIs
StatePublished - Jan 2006

Fingerprint

Macular Degeneration
Homocysteine
Eye Diseases
Photography
Case-Control Studies
Fasting
Logistic Models
Regression Analysis

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Evaluation of plasma homocysteine and risk of age-related macular degeneration. / Seddon, Johanna M.; Gensler, Gary; Klein, Michael; Milton, Roy C.

In: American Journal of Ophthalmology, Vol. 141, No. 1, 01.2006, p. 201-203.

Research output: Contribution to journalArticle

Seddon, Johanna M. ; Gensler, Gary ; Klein, Michael ; Milton, Roy C. / Evaluation of plasma homocysteine and risk of age-related macular degeneration. In: American Journal of Ophthalmology. 2006 ; Vol. 141, No. 1. pp. 201-203.
@article{26daa6afe4314dbe9ed7c27626cbc4b0,
title = "Evaluation of plasma homocysteine and risk of age-related macular degeneration",
abstract = "PURPOSE: To assess the relationship between plasma levels of homocysteine and age-related macular degeneration (AMD). DESIGN: Cross-sectional, case-control study. METHODS: Fasting plasma homocysteine levels were measured at two centers in 934 individuals who were participating in an ancillary study of the Age-Related Eye Disease Study. There were 547 cases and 387 control subjects, who were determined by fundus photography. Conditional logistic regression analyses were conducted to assess the association of homocysteine with AMD. RESULTS: Median values of homocysteine were higher among advanced AMD cases (9.51 mmol/l) compared with persons with no AMD (8.81 mmol/l; P = .01). Values of >12 mmol/l vs ≤12 mmol/l were also associated with an increased risk of AMD (P = .023), when controlled for other covariates. CONCLUSION: Results are consistent with a possible small, independent association between higher homocysteine levels and AMD. Homocysteine may be a modifiable risk factor for AMD.",
author = "Seddon, {Johanna M.} and Gary Gensler and Michael Klein and Milton, {Roy C.}",
year = "2006",
month = "1",
doi = "10.1016/j.ajo.2005.07.059",
language = "English (US)",
volume = "141",
pages = "201--203",
journal = "American Journal of Ophthalmology",
issn = "0002-9394",
publisher = "Elsevier USA",
number = "1",

}

TY - JOUR

T1 - Evaluation of plasma homocysteine and risk of age-related macular degeneration

AU - Seddon, Johanna M.

AU - Gensler, Gary

AU - Klein, Michael

AU - Milton, Roy C.

PY - 2006/1

Y1 - 2006/1

N2 - PURPOSE: To assess the relationship between plasma levels of homocysteine and age-related macular degeneration (AMD). DESIGN: Cross-sectional, case-control study. METHODS: Fasting plasma homocysteine levels were measured at two centers in 934 individuals who were participating in an ancillary study of the Age-Related Eye Disease Study. There were 547 cases and 387 control subjects, who were determined by fundus photography. Conditional logistic regression analyses were conducted to assess the association of homocysteine with AMD. RESULTS: Median values of homocysteine were higher among advanced AMD cases (9.51 mmol/l) compared with persons with no AMD (8.81 mmol/l; P = .01). Values of >12 mmol/l vs ≤12 mmol/l were also associated with an increased risk of AMD (P = .023), when controlled for other covariates. CONCLUSION: Results are consistent with a possible small, independent association between higher homocysteine levels and AMD. Homocysteine may be a modifiable risk factor for AMD.

AB - PURPOSE: To assess the relationship between plasma levels of homocysteine and age-related macular degeneration (AMD). DESIGN: Cross-sectional, case-control study. METHODS: Fasting plasma homocysteine levels were measured at two centers in 934 individuals who were participating in an ancillary study of the Age-Related Eye Disease Study. There were 547 cases and 387 control subjects, who were determined by fundus photography. Conditional logistic regression analyses were conducted to assess the association of homocysteine with AMD. RESULTS: Median values of homocysteine were higher among advanced AMD cases (9.51 mmol/l) compared with persons with no AMD (8.81 mmol/l; P = .01). Values of >12 mmol/l vs ≤12 mmol/l were also associated with an increased risk of AMD (P = .023), when controlled for other covariates. CONCLUSION: Results are consistent with a possible small, independent association between higher homocysteine levels and AMD. Homocysteine may be a modifiable risk factor for AMD.

UR - http://www.scopus.com/inward/record.url?scp=29544443447&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=29544443447&partnerID=8YFLogxK

U2 - 10.1016/j.ajo.2005.07.059

DO - 10.1016/j.ajo.2005.07.059

M3 - Article

VL - 141

SP - 201

EP - 203

JO - American Journal of Ophthalmology

JF - American Journal of Ophthalmology

SN - 0002-9394

IS - 1

ER -