Evaluation of aortic regurgitation with digitally determined color Doppler-imaged flow convergence acceleration

A quantitative study in sheep

Takahiro Shiota, Michael Jones, Izumi Yamada, Russell S. Heinrich, Masahiro Ishii, Brian Sinclair, Ajit P. Yoganathan, David Sahn

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Objectives. The aim of the present study was to validate a digital color Doppler-based centerline velocity/distance acceleration profile method for evaluating the severity of aortic regurgitation. Background. Clinical and in vivo experimental applications of the flow convergence axial centerline velocity/distance profile method have recently been used to estimate regurgitant flow rates and regurgitant volumes in the presence of mitral regurgitation. Methods. In six sheep, a total of 19 hemodynamic states were obtained pharmacologically 14 weeks after the original operation in which a portion of the aortic noncoronary (n = 3) or right coronary (n = 3) leaflet was excised to produce aortic regurgitation. Echocardiographic studies were performed to obtain complete proximal axial how acceleration velocity/distance profiles during the time of peak regurgitant flow (usually early in diastole) for each hemodynamic state. For each steady state, the severity of aortic regurgitation was assessed by measurement of the magnitude of the regurgitant flow volume/beat, regurgitant fraction and instantaneous regurgitant flow rates determined by using both aortic and pulmonary artery electromagnetic how probes. Results. Grade I regurgitation (regurgitant volume/beat 30 ml, eight conditions) were clearly separated by using the color Doppler centerline velocity/distance profile domain technique. Additionally, an equation for correlating 'a' (the coefficient from the multiplicative curve fit for the velocity/distance relation) with the peak regurgitant flow rates (Q [liters/min]) was derived shelving a high correlation between calculated peak flow rates by the color Doppler method and the actual peak flow rates (Q = 13a + 1.0, r = 0.95, p <0.0001, SEE = 0.76 liters/min). Conclusions. This study, using quantified aortic regurgitation, demonstrates that the flow convergence axial centerline velocity/distance acceleration profile method can be used to evaluate the severity of aortic regurgitation.

Original languageEnglish (US)
Pages (from-to)203-210
Number of pages8
JournalJournal of the American College of Cardiology
Volume27
Issue number1
DOIs
StatePublished - Jan 1996

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Aortic Valve Insufficiency
Sheep
Color
Hemodynamics
Diastole
Electromagnetic Phenomena
Mitral Valve Insufficiency
Pulmonary Artery

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Evaluation of aortic regurgitation with digitally determined color Doppler-imaged flow convergence acceleration : A quantitative study in sheep. / Shiota, Takahiro; Jones, Michael; Yamada, Izumi; Heinrich, Russell S.; Ishii, Masahiro; Sinclair, Brian; Yoganathan, Ajit P.; Sahn, David.

In: Journal of the American College of Cardiology, Vol. 27, No. 1, 01.1996, p. 203-210.

Research output: Contribution to journalArticle

Shiota, Takahiro ; Jones, Michael ; Yamada, Izumi ; Heinrich, Russell S. ; Ishii, Masahiro ; Sinclair, Brian ; Yoganathan, Ajit P. ; Sahn, David. / Evaluation of aortic regurgitation with digitally determined color Doppler-imaged flow convergence acceleration : A quantitative study in sheep. In: Journal of the American College of Cardiology. 1996 ; Vol. 27, No. 1. pp. 203-210.
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abstract = "Objectives. The aim of the present study was to validate a digital color Doppler-based centerline velocity/distance acceleration profile method for evaluating the severity of aortic regurgitation. Background. Clinical and in vivo experimental applications of the flow convergence axial centerline velocity/distance profile method have recently been used to estimate regurgitant flow rates and regurgitant volumes in the presence of mitral regurgitation. Methods. In six sheep, a total of 19 hemodynamic states were obtained pharmacologically 14 weeks after the original operation in which a portion of the aortic noncoronary (n = 3) or right coronary (n = 3) leaflet was excised to produce aortic regurgitation. Echocardiographic studies were performed to obtain complete proximal axial how acceleration velocity/distance profiles during the time of peak regurgitant flow (usually early in diastole) for each hemodynamic state. For each steady state, the severity of aortic regurgitation was assessed by measurement of the magnitude of the regurgitant flow volume/beat, regurgitant fraction and instantaneous regurgitant flow rates determined by using both aortic and pulmonary artery electromagnetic how probes. Results. Grade I regurgitation (regurgitant volume/beat 30 ml, eight conditions) were clearly separated by using the color Doppler centerline velocity/distance profile domain technique. Additionally, an equation for correlating 'a' (the coefficient from the multiplicative curve fit for the velocity/distance relation) with the peak regurgitant flow rates (Q [liters/min]) was derived shelving a high correlation between calculated peak flow rates by the color Doppler method and the actual peak flow rates (Q = 13a + 1.0, r = 0.95, p <0.0001, SEE = 0.76 liters/min). Conclusions. This study, using quantified aortic regurgitation, demonstrates that the flow convergence axial centerline velocity/distance acceleration profile method can be used to evaluate the severity of aortic regurgitation.",
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