Evaluating global and regional left ventricular function in patients with reperfused acute myocardial infarction by 64-slice multidetector CT

A comparison to magnetic resonance imaging

Ammar Sarwar, Michael Shapiro, Khurram Nasir, Koen Nieman, Cesar H. Nomura, Thomas J. Brady, Ricardo C. Cury

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background: A number of studies have compared 64-slice multidetector row computed tomography (MDCT) and magnetic resonance imaging (MRI) for left ventricular (LV) function; however, none were performed in patients with reperfused acute myocardial infarction. Objectives: We compared global and regional LV function assessment by 64-slice CT (MDCT) with cardiac magnetic resonance (CMR) after reperfused ST elevation myocardial infarction. Methods: Twenty-one patients were scanned after reperfusion with contrast-enhanced CMR and MDCT. Reconstructed short axis images were used to assess global (quantitative assessment of LF end-diastolic volume [LVEDV], end-systolic volume [LVESV], stroke volume [LVSV], ejection fraction [LVEF], and mass, by Simpson's method) and regional cardiac function (qualitative assessment on a 4-point scale [4 = normal, 3 = hypokinesia, 2 = dyskinesia, 1 = akinesia]) in a standard 17-segment myocardial model. Results: We scanned 21 persons (age, 60 ± 10 years; 19 men) with CMR and MDCT. Good correlation was observed for all global parameters between MDCT and CMR (LVEF, r = 0.90; LVEDV, r = 0.91; LVESV, r = 0.94; LVSV, r = 0.84; LV mass, r = 0.91). Interobserver agreement for regional function was excellent (weighted κ, 0.81). The interobserver agreement for regional function on MDCT and CMR were comparable (weighted κ of 0.86 and 0.88, respectively). MDCT had a better sensitivity, specificity, positive predictive value, and negative predictive value for akinetic segments on CMR than did hypokinetic segments (71%, 91%, 68%, and 93% versus 84%, 97%, 81%, and 98%, respectively). Conclusion: MDCT provides an accurate and reproducible measurement of regional and global LV function in patients with reperfused acute myocardial infarction.

Original languageEnglish (US)
Pages (from-to)170-177
Number of pages8
JournalJournal of Cardiovascular Computed Tomography
Volume3
Issue number3
DOIs
StatePublished - May 2009
Externally publishedYes

Fingerprint

Multidetector Computed Tomography
Left Ventricular Function
Myocardial Infarction
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Stroke Volume
Hypokinesia
Dyskinesias
Reperfusion
Sensitivity and Specificity

Keywords

  • Cardiac magnetic resonance imaging
  • Left ventricular function
  • Multidetector row computed tomography
  • Myocardial infarction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Evaluating global and regional left ventricular function in patients with reperfused acute myocardial infarction by 64-slice multidetector CT : A comparison to magnetic resonance imaging. / Sarwar, Ammar; Shapiro, Michael; Nasir, Khurram; Nieman, Koen; Nomura, Cesar H.; Brady, Thomas J.; Cury, Ricardo C.

In: Journal of Cardiovascular Computed Tomography, Vol. 3, No. 3, 05.2009, p. 170-177.

Research output: Contribution to journalArticle

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abstract = "Background: A number of studies have compared 64-slice multidetector row computed tomography (MDCT) and magnetic resonance imaging (MRI) for left ventricular (LV) function; however, none were performed in patients with reperfused acute myocardial infarction. Objectives: We compared global and regional LV function assessment by 64-slice CT (MDCT) with cardiac magnetic resonance (CMR) after reperfused ST elevation myocardial infarction. Methods: Twenty-one patients were scanned after reperfusion with contrast-enhanced CMR and MDCT. Reconstructed short axis images were used to assess global (quantitative assessment of LF end-diastolic volume [LVEDV], end-systolic volume [LVESV], stroke volume [LVSV], ejection fraction [LVEF], and mass, by Simpson's method) and regional cardiac function (qualitative assessment on a 4-point scale [4 = normal, 3 = hypokinesia, 2 = dyskinesia, 1 = akinesia]) in a standard 17-segment myocardial model. Results: We scanned 21 persons (age, 60 ± 10 years; 19 men) with CMR and MDCT. Good correlation was observed for all global parameters between MDCT and CMR (LVEF, r = 0.90; LVEDV, r = 0.91; LVESV, r = 0.94; LVSV, r = 0.84; LV mass, r = 0.91). Interobserver agreement for regional function was excellent (weighted κ, 0.81). The interobserver agreement for regional function on MDCT and CMR were comparable (weighted κ of 0.86 and 0.88, respectively). MDCT had a better sensitivity, specificity, positive predictive value, and negative predictive value for akinetic segments on CMR than did hypokinetic segments (71{\%}, 91{\%}, 68{\%}, and 93{\%} versus 84{\%}, 97{\%}, 81{\%}, and 98{\%}, respectively). Conclusion: MDCT provides an accurate and reproducible measurement of regional and global LV function in patients with reperfused acute myocardial infarction.",
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T1 - Evaluating global and regional left ventricular function in patients with reperfused acute myocardial infarction by 64-slice multidetector CT

T2 - A comparison to magnetic resonance imaging

AU - Sarwar, Ammar

AU - Shapiro, Michael

AU - Nasir, Khurram

AU - Nieman, Koen

AU - Nomura, Cesar H.

AU - Brady, Thomas J.

AU - Cury, Ricardo C.

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N2 - Background: A number of studies have compared 64-slice multidetector row computed tomography (MDCT) and magnetic resonance imaging (MRI) for left ventricular (LV) function; however, none were performed in patients with reperfused acute myocardial infarction. Objectives: We compared global and regional LV function assessment by 64-slice CT (MDCT) with cardiac magnetic resonance (CMR) after reperfused ST elevation myocardial infarction. Methods: Twenty-one patients were scanned after reperfusion with contrast-enhanced CMR and MDCT. Reconstructed short axis images were used to assess global (quantitative assessment of LF end-diastolic volume [LVEDV], end-systolic volume [LVESV], stroke volume [LVSV], ejection fraction [LVEF], and mass, by Simpson's method) and regional cardiac function (qualitative assessment on a 4-point scale [4 = normal, 3 = hypokinesia, 2 = dyskinesia, 1 = akinesia]) in a standard 17-segment myocardial model. Results: We scanned 21 persons (age, 60 ± 10 years; 19 men) with CMR and MDCT. Good correlation was observed for all global parameters between MDCT and CMR (LVEF, r = 0.90; LVEDV, r = 0.91; LVESV, r = 0.94; LVSV, r = 0.84; LV mass, r = 0.91). Interobserver agreement for regional function was excellent (weighted κ, 0.81). The interobserver agreement for regional function on MDCT and CMR were comparable (weighted κ of 0.86 and 0.88, respectively). MDCT had a better sensitivity, specificity, positive predictive value, and negative predictive value for akinetic segments on CMR than did hypokinetic segments (71%, 91%, 68%, and 93% versus 84%, 97%, 81%, and 98%, respectively). Conclusion: MDCT provides an accurate and reproducible measurement of regional and global LV function in patients with reperfused acute myocardial infarction.

AB - Background: A number of studies have compared 64-slice multidetector row computed tomography (MDCT) and magnetic resonance imaging (MRI) for left ventricular (LV) function; however, none were performed in patients with reperfused acute myocardial infarction. Objectives: We compared global and regional LV function assessment by 64-slice CT (MDCT) with cardiac magnetic resonance (CMR) after reperfused ST elevation myocardial infarction. Methods: Twenty-one patients were scanned after reperfusion with contrast-enhanced CMR and MDCT. Reconstructed short axis images were used to assess global (quantitative assessment of LF end-diastolic volume [LVEDV], end-systolic volume [LVESV], stroke volume [LVSV], ejection fraction [LVEF], and mass, by Simpson's method) and regional cardiac function (qualitative assessment on a 4-point scale [4 = normal, 3 = hypokinesia, 2 = dyskinesia, 1 = akinesia]) in a standard 17-segment myocardial model. Results: We scanned 21 persons (age, 60 ± 10 years; 19 men) with CMR and MDCT. Good correlation was observed for all global parameters between MDCT and CMR (LVEF, r = 0.90; LVEDV, r = 0.91; LVESV, r = 0.94; LVSV, r = 0.84; LV mass, r = 0.91). Interobserver agreement for regional function was excellent (weighted κ, 0.81). The interobserver agreement for regional function on MDCT and CMR were comparable (weighted κ of 0.86 and 0.88, respectively). MDCT had a better sensitivity, specificity, positive predictive value, and negative predictive value for akinetic segments on CMR than did hypokinetic segments (71%, 91%, 68%, and 93% versus 84%, 97%, 81%, and 98%, respectively). Conclusion: MDCT provides an accurate and reproducible measurement of regional and global LV function in patients with reperfused acute myocardial infarction.

KW - Cardiac magnetic resonance imaging

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KW - Multidetector row computed tomography

KW - Myocardial infarction

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