Etiology of xerostomia and dental caries among methamphetamine abusers.

Tarnjit Saini, Paul C. Edwards, Nicole Kimmes, Lucinda R. Carroll, John W. Shaner, Frank J. Dowd

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

This study reviews the peripheral effects of methamphetamine on the salivary acini, the pathogenesis of methamphetamine-induced xerostomia, and its anecdotal relationship to dental caries. Methamphetamine is a sympathomimetic central stimulant which is abused for its euphoric effects. Its pharmacological action is exerted indirectly by sustaining high levels of catecholamines in the synaptic cleft and directly by binding to the postsynaptic adrenergic receptors. Methamphetamine abusers report subjective perception of xerostomia, which cannot be explained by the direct peripheral action of methamphetamine on the secretory acini. The drug may cause a decrease in salivary flow rate by centrally inhibiting salivatory nuclei via stimulation of alpha-2 receptors in the brain. Drug mediated dehydration state may influence the perception of dry mouth in abusers. The decreased salivary flow rate, either due to a central inhibitory action of methamphetamine or generalised dehydration, likely contributes to the increased occurrence of dental caries. Five cases of methamphetamine abuse are presented, three of whom experienced rampant dental caries. A direct association between methamphetamine abuse and the occurrence of rampant caries was not clear.

Original languageEnglish (US)
Pages (from-to)189-195
Number of pages7
JournalOral health & preventive dentistry
Volume3
Issue number3
StatePublished - 2005
Externally publishedYes

Fingerprint

Xerostomia
Methamphetamine
Dental Caries
Dehydration
Central Nervous System Stimulants
Sympathomimetics
Pharmaceutical Preparations
Adrenergic Receptors
Catecholamines
Mouth
Pharmacology
Brain

Cite this

Saini, T., Edwards, P. C., Kimmes, N., Carroll, L. R., Shaner, J. W., & Dowd, F. J. (2005). Etiology of xerostomia and dental caries among methamphetamine abusers. Oral health & preventive dentistry, 3(3), 189-195.

Etiology of xerostomia and dental caries among methamphetamine abusers. / Saini, Tarnjit; Edwards, Paul C.; Kimmes, Nicole; Carroll, Lucinda R.; Shaner, John W.; Dowd, Frank J.

In: Oral health & preventive dentistry, Vol. 3, No. 3, 2005, p. 189-195.

Research output: Contribution to journalArticle

Saini, T, Edwards, PC, Kimmes, N, Carroll, LR, Shaner, JW & Dowd, FJ 2005, 'Etiology of xerostomia and dental caries among methamphetamine abusers.', Oral health & preventive dentistry, vol. 3, no. 3, pp. 189-195.
Saini T, Edwards PC, Kimmes N, Carroll LR, Shaner JW, Dowd FJ. Etiology of xerostomia and dental caries among methamphetamine abusers. Oral health & preventive dentistry. 2005;3(3):189-195.
Saini, Tarnjit ; Edwards, Paul C. ; Kimmes, Nicole ; Carroll, Lucinda R. ; Shaner, John W. ; Dowd, Frank J. / Etiology of xerostomia and dental caries among methamphetamine abusers. In: Oral health & preventive dentistry. 2005 ; Vol. 3, No. 3. pp. 189-195.
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