Ethanol-related traits in mice selectively bred for differential sensitivity to methamphetamine-induced activation

Helen M. Kamens, Sue Burkhart-Kasch, Carrie S. McKinnon, Na Li, Cheryl Reed, Tamara J. Phillips

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Acute drug stimulation has been proposed to be an endophenotype for drug abuse. The authors previously reported the short-term selective breeding of lines of mice for low (LMACT) and high (HMACT) stimulation to methamphetamine (MA). These mice were used to examine whether common genes influence the locomotor response to MA and ethanol. Additionally, the authors tested these mice for ethanol drinking, locomotor sensitization, and clearance. LMACT mice were less stimulated by ethanol and consumed more ethanol than HMACT mice, but the lines did not differ in ethanol-induced sensitization. A small difference in ethanol clearance rate (0.1 mg/ml/h) likely had little impact on behavior. Some common genes may influence the locomotor response to MA and ethanol, as well as ethanol drinking. (PsycINFO Database Record (c) 2006 APA, all rights reserved).

Original languageEnglish (US)
Pages (from-to)1356-1366
Number of pages11
JournalBehavioral Neuroscience
Volume120
Issue number6
DOIs
StatePublished - Dec 1 2006

Keywords

  • Drinking
  • Locomotor activity
  • Selective breeding
  • Sensitization
  • Stimulation

ASJC Scopus subject areas

  • Behavioral Neuroscience

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