Estrogen Signaling in the Hypothalamus

Research output: Chapter in Book/Report/Conference proceedingChapter

37 Scopus citations

Abstract

Estrogen has multifaceted effects on the hypothalamus that regulate a number of homeostatic functions including reproduction, temperature, energy balance, stress, and motivated behaviors. Estrogen targets all of the major hypothalamic neuroendocrine and autonomic cellular groups to activate multiple signaling pathways. Originally it was thought that all of these actions of estrogen could be ascribed to its binding to its "classical" intracellular receptor and to alterations in gene transcription. However, we now know that this steroid hormone activates multiple signaling pathways to affect neuronal excitability and gene transcription. Although the "classical" genomic signaling pathway has been recognized for almost half a century, until recently little attention has been paid to the rapid membrane-initiated signaling by estrogen in neurons. It has been known since the 1970s that estrogen can rapidly alter neuronal firing within seconds, indicating that some cellular effects of estrogen could occur via rapid, nontranscriptional mechanisms. Therefore, this chapter reviews the current status of estrogen signaling in the hypothalamus via membrane-initiated and nuclear-mediated events that affect the excitability of hypothalamic neurons and, ultimately, neuroendocrine and autonomic functions.

Original languageEnglish (US)
Title of host publicationVitamins and Hormones
EditorsGerald Litwack
Pages123-145
Number of pages23
DOIs
StatePublished - Dec 1 2005

Publication series

NameVitamins and Hormones
Volume71
ISSN (Print)0083-6729

ASJC Scopus subject areas

  • Physiology
  • Endocrinology

Fingerprint Dive into the research topics of 'Estrogen Signaling in the Hypothalamus'. Together they form a unique fingerprint.

Cite this