Estrogen modulation of G-protein-coupled receptors

Martin Kelly, Edward J. Wagner

Research output: Contribution to journalArticle

186 Citations (Scopus)

Abstract

Estrogen exerts long-term effects in almost every cell through regulation of gene transcription. However, it has been known for some time that estrogen can rapidly alter neuronal firing within seconds, indicating that some cellular effects of estrogen could occur via non-genomic mechanisms. G-protein-coupled receptors (GPCRs) are the largest class of membrane-bound receptors, and it appears that many of the rapid effects mediated by estrogen could involve changes in GPCR-effector system coupling in excitable cells within the reproductive axis.

Original languageEnglish (US)
Pages (from-to)369-374
Number of pages6
JournalTrends in Endocrinology and Metabolism
Volume10
Issue number9
DOIs
StatePublished - Nov 1 1999

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G-Protein-Coupled Receptors
Estrogens
Membranes
Genes

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Estrogen modulation of G-protein-coupled receptors. / Kelly, Martin; Wagner, Edward J.

In: Trends in Endocrinology and Metabolism, Vol. 10, No. 9, 01.11.1999, p. 369-374.

Research output: Contribution to journalArticle

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