Essential roles in synaptic plasticity for synaptogyrin I and synaptophysin I

Roger Janz, Thomas C. Südhof, Robert E. Hammer, Vivek Unni, Steven A. Siegelbaum, Vadim Y. Bolshakov

Research output: Contribution to journalArticle

216 Citations (Scopus)

Abstract

We have generated mice lacking synaptogyrin I and synaptophysin I to explore the functions of these abundant tyrosine-phosphorylated proteins of synaptic vesicles. Single and double knockout mice were alive and fertile without significant morphological or biochemical changes. Electrophysiological recordings in the hippocampal CA1 region revealed that short-term and long-term synaptic plasticity were severely reduced in the synaptophysin/synaptogyrin double knockout mice. LTP was decreased independent of the induction protocol, suggesting that the defect in LTP was not caused by insufficient induction. Our data show that synaptogyrin I and synaptophysin I perform redundant and essential functions in synaptic plasticity without being required for neurotransmitter release itself.

Original languageEnglish (US)
Pages (from-to)687-700
Number of pages14
JournalNeuron
Volume24
Issue number3
StatePublished - Nov 1999
Externally publishedYes

Fingerprint

Synaptogyrins
Synaptophysin
Neuronal Plasticity
Knockout Mice
Hippocampal CA1 Region
Synaptic Vesicles
Neurotransmitter Agents
Tyrosine
Proteins

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Janz, R., Südhof, T. C., Hammer, R. E., Unni, V., Siegelbaum, S. A., & Bolshakov, V. Y. (1999). Essential roles in synaptic plasticity for synaptogyrin I and synaptophysin I. Neuron, 24(3), 687-700.

Essential roles in synaptic plasticity for synaptogyrin I and synaptophysin I. / Janz, Roger; Südhof, Thomas C.; Hammer, Robert E.; Unni, Vivek; Siegelbaum, Steven A.; Bolshakov, Vadim Y.

In: Neuron, Vol. 24, No. 3, 11.1999, p. 687-700.

Research output: Contribution to journalArticle

Janz, R, Südhof, TC, Hammer, RE, Unni, V, Siegelbaum, SA & Bolshakov, VY 1999, 'Essential roles in synaptic plasticity for synaptogyrin I and synaptophysin I', Neuron, vol. 24, no. 3, pp. 687-700.
Janz R, Südhof TC, Hammer RE, Unni V, Siegelbaum SA, Bolshakov VY. Essential roles in synaptic plasticity for synaptogyrin I and synaptophysin I. Neuron. 1999 Nov;24(3):687-700.
Janz, Roger ; Südhof, Thomas C. ; Hammer, Robert E. ; Unni, Vivek ; Siegelbaum, Steven A. ; Bolshakov, Vadim Y. / Essential roles in synaptic plasticity for synaptogyrin I and synaptophysin I. In: Neuron. 1999 ; Vol. 24, No. 3. pp. 687-700.
@article{b157b24c318f44d6a0a10150cc4f3643,
title = "Essential roles in synaptic plasticity for synaptogyrin I and synaptophysin I",
abstract = "We have generated mice lacking synaptogyrin I and synaptophysin I to explore the functions of these abundant tyrosine-phosphorylated proteins of synaptic vesicles. Single and double knockout mice were alive and fertile without significant morphological or biochemical changes. Electrophysiological recordings in the hippocampal CA1 region revealed that short-term and long-term synaptic plasticity were severely reduced in the synaptophysin/synaptogyrin double knockout mice. LTP was decreased independent of the induction protocol, suggesting that the defect in LTP was not caused by insufficient induction. Our data show that synaptogyrin I and synaptophysin I perform redundant and essential functions in synaptic plasticity without being required for neurotransmitter release itself.",
author = "Roger Janz and S{\"u}dhof, {Thomas C.} and Hammer, {Robert E.} and Vivek Unni and Siegelbaum, {Steven A.} and Bolshakov, {Vadim Y.}",
year = "1999",
month = "11",
language = "English (US)",
volume = "24",
pages = "687--700",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "3",

}

TY - JOUR

T1 - Essential roles in synaptic plasticity for synaptogyrin I and synaptophysin I

AU - Janz, Roger

AU - Südhof, Thomas C.

AU - Hammer, Robert E.

AU - Unni, Vivek

AU - Siegelbaum, Steven A.

AU - Bolshakov, Vadim Y.

PY - 1999/11

Y1 - 1999/11

N2 - We have generated mice lacking synaptogyrin I and synaptophysin I to explore the functions of these abundant tyrosine-phosphorylated proteins of synaptic vesicles. Single and double knockout mice were alive and fertile without significant morphological or biochemical changes. Electrophysiological recordings in the hippocampal CA1 region revealed that short-term and long-term synaptic plasticity were severely reduced in the synaptophysin/synaptogyrin double knockout mice. LTP was decreased independent of the induction protocol, suggesting that the defect in LTP was not caused by insufficient induction. Our data show that synaptogyrin I and synaptophysin I perform redundant and essential functions in synaptic plasticity without being required for neurotransmitter release itself.

AB - We have generated mice lacking synaptogyrin I and synaptophysin I to explore the functions of these abundant tyrosine-phosphorylated proteins of synaptic vesicles. Single and double knockout mice were alive and fertile without significant morphological or biochemical changes. Electrophysiological recordings in the hippocampal CA1 region revealed that short-term and long-term synaptic plasticity were severely reduced in the synaptophysin/synaptogyrin double knockout mice. LTP was decreased independent of the induction protocol, suggesting that the defect in LTP was not caused by insufficient induction. Our data show that synaptogyrin I and synaptophysin I perform redundant and essential functions in synaptic plasticity without being required for neurotransmitter release itself.

UR - http://www.scopus.com/inward/record.url?scp=0033230745&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033230745&partnerID=8YFLogxK

M3 - Article

C2 - 10595519

AN - SCOPUS:0033230745

VL - 24

SP - 687

EP - 700

JO - Neuron

JF - Neuron

SN - 0896-6273

IS - 3

ER -