Epithelial cell surfaces induce Salmonella proteins required for bacterial adherence and invasion

B. Brett Finlay, Fred Heffron, Stanley Falkow

    Research output: Contribution to journalArticle

    107 Scopus citations

    Abstract

    Salmonella bacteria are capable ofentering (invading) and multiplying within eukaryotic cells. Stable adherence to and invasion of epithelial cells by S. choleraesuis and S. typhimurium were found to require de novo synthesis of several new bacterial proteins. This inducible event appears to be a coordinately regulated system dependent on trypsin- and neuraminidase-sensitive structures present on the epithelial cell surface. Mutants of S. choleraesuis and S. typhimurium were unable to synthesize these proteins and did not stably adhere to nor invade eukaryotic cells. Two such S. typhimurium mutants were avirulent in mice, an indication that these proteins are required for Salmonella virulence.

    Original languageEnglish (US)
    Pages (from-to)940-943
    Number of pages4
    JournalScience
    Volume243
    Issue number4893
    DOIs
    StatePublished - 1989

    ASJC Scopus subject areas

    • General

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