Epigenetic regulation of androgen receptor signaling in prostate cancer

Lina Gao, Joshi Alumkal

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

Prostate cancer is the most common cancer in men in the United States, and it is the second leading cause of cancer-related death in American men. The Androgen receptor (AR), a nuclear hormone and transcription factor, is the most therapeutically relevant target in this disease. While most efforts in the clinic are still directed at lowering levels of androgens that activate AR, resistance to androgen deprivation eventually develops, and most prostate cancer deaths are attributable to this castration-resistant form of this disease. Recent work has shed light on the importance of epigenetic events including facilitation of AR signaling by histone-modifying enzymes and also on the role that enzymes such as HDAC6 play in stabilizing AR in prostate cancer cells. Herein, we summarize recent findings on the role of epigenetic enzymes in AR signaling and highlight examples on how interdiction of critical epigenetic enzymes may attenuate AR action in prostate cancer.

Original languageEnglish (US)
Pages (from-to)100-104
Number of pages5
JournalEpigenetics
Volume5
Issue number2
DOIs
StatePublished - Feb 2010
Externally publishedYes

Keywords

  • AR
  • Epigenetics
  • Histone deacetylase
  • Histone demethylase
  • Prostate cancer

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research

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