Eosinophil-associated inflammation in bronchial asthma: A connection to the nervous system

Gerald J. Gleich, David Jacoby, Allison Fryer

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Evidence exists that eosinophil cationic proteins damage respiratory epithelium in bronchial asthma. Furthermore, the degree of eosinophilia in the blood and the lung is related to bronchial hyperreactivity. The eosinophil might increase airway irritability by increasing vagal responsiveness. Sensitized challenged guinea pigs develop muscarinic receptor cholinergic dysfunction which is abolished by injection of heparin or polyglutamate and both the eosinophil granule major basic protein and the eosinophil peroxidase act as allosteric M: Receptor antagonists. Thus, eosinophil-associated pulmonary inflammation in asthma may enhance vagally mediated bronchoconstriction.

Original languageEnglish (US)
Pages (from-to)205-207
Number of pages3
JournalInternational Archives of Allergy and Immunology
Volume107
Issue number1-3
DOIs
StatePublished - 1995
Externally publishedYes

Fingerprint

Eosinophils
Nervous System
Eosinophil Major Basic Protein
Asthma
Eosinophil Peroxidase
Polyglutamic Acid
Eosinophil Cationic Protein
Inflammation
Bronchial Hyperreactivity
Respiratory Mucosa
Bronchoconstriction
Eosinophilia
Muscarinic Receptors
Cholinergic Agents
Heparin
Pneumonia
Guinea Pigs
Lung
Injections

Keywords

  • Bronchial asthma
  • Eosinophils
  • Inflammation
  • Muscarinic receptor
  • Vagus nerve

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Eosinophil-associated inflammation in bronchial asthma : A connection to the nervous system. / Gleich, Gerald J.; Jacoby, David; Fryer, Allison.

In: International Archives of Allergy and Immunology, Vol. 107, No. 1-3, 1995, p. 205-207.

Research output: Contribution to journalArticle

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