Eosinophil-associated inflammation in bronchial asthma: A connection to the nervous system

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Evidence exists that eosinophil cationic proteins damage respiratory epithelium in bronchial asthma. Furthermore, the degree of eosinophilia in the blood and the lung is related to bronchial hyperreactivity. The eosinophil might increase airway irritability by increasing vagal responsiveness. Sensitized challenged guinea pigs develop muscarinic receptor cholinergic dysfunction which is abolished by injection of heparin or polyglutamate and both the eosinophil granule major basic protein and the eosinophil peroxidase act as allosteric M: Receptor antagonists. Thus, eosinophil-associated pulmonary inflammation in asthma may enhance vagally mediated bronchoconstriction.

Original languageEnglish (US)
Pages (from-to)205-207
Number of pages3
JournalInternational Archives of Allergy and Immunology
Volume107
Issue number1-3
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

Keywords

  • Bronchial asthma
  • Eosinophils
  • Inflammation
  • Muscarinic receptor
  • Vagus nerve

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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