Engaging neuroscience to advance translational research in brain barrier biology

Edward Neuwelt, Björn Bauer, Christoph Fahlke, Gert Fricker, Constantino Iadecola, Damir Janigro, Luc Leybaert, Zoltán Molnár, Martha E. O'Donnell, John T. Povlishock, Norman R. Saunders, Frank Sharp, Danica Stanimirovic, Ryan J. Watts, Lester R. Drewes

Research output: Contribution to journalArticle

320 Citations (Scopus)

Abstract

The delivery of many potentially therapeutic and diagnostic compounds to specific areas of the brain is restricted by brain barriers, of which the most well known are the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier. Recent studies have shown numerous additional roles of these barriers, including an involvement in neurodevelopment, in the control of cerebral blood flow, and - when barrier integrity is impaired - in the pathology of many common CNS disorders such as Alzheimer's disease, Parkinson's disease and stroke.

Original languageEnglish (US)
Pages (from-to)169-182
Number of pages14
JournalNature Reviews Neuroscience
Volume12
Issue number3
DOIs
StatePublished - Mar 2011

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Translational Medical Research
Neurosciences
Cerebrovascular Circulation
Brain
Blood-Brain Barrier
Parkinson Disease
Cerebrospinal Fluid
Alzheimer Disease
Stroke
Pathology
Therapeutics

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Neuwelt, E., Bauer, B., Fahlke, C., Fricker, G., Iadecola, C., Janigro, D., ... Drewes, L. R. (2011). Engaging neuroscience to advance translational research in brain barrier biology. Nature Reviews Neuroscience, 12(3), 169-182. https://doi.org/10.1038/nrn2995

Engaging neuroscience to advance translational research in brain barrier biology. / Neuwelt, Edward; Bauer, Björn; Fahlke, Christoph; Fricker, Gert; Iadecola, Constantino; Janigro, Damir; Leybaert, Luc; Molnár, Zoltán; O'Donnell, Martha E.; Povlishock, John T.; Saunders, Norman R.; Sharp, Frank; Stanimirovic, Danica; Watts, Ryan J.; Drewes, Lester R.

In: Nature Reviews Neuroscience, Vol. 12, No. 3, 03.2011, p. 169-182.

Research output: Contribution to journalArticle

Neuwelt, E, Bauer, B, Fahlke, C, Fricker, G, Iadecola, C, Janigro, D, Leybaert, L, Molnár, Z, O'Donnell, ME, Povlishock, JT, Saunders, NR, Sharp, F, Stanimirovic, D, Watts, RJ & Drewes, LR 2011, 'Engaging neuroscience to advance translational research in brain barrier biology', Nature Reviews Neuroscience, vol. 12, no. 3, pp. 169-182. https://doi.org/10.1038/nrn2995
Neuwelt, Edward ; Bauer, Björn ; Fahlke, Christoph ; Fricker, Gert ; Iadecola, Constantino ; Janigro, Damir ; Leybaert, Luc ; Molnár, Zoltán ; O'Donnell, Martha E. ; Povlishock, John T. ; Saunders, Norman R. ; Sharp, Frank ; Stanimirovic, Danica ; Watts, Ryan J. ; Drewes, Lester R. / Engaging neuroscience to advance translational research in brain barrier biology. In: Nature Reviews Neuroscience. 2011 ; Vol. 12, No. 3. pp. 169-182.
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