Energy metabolism and contractile function after 15 beats of moderate myocardial ischemia

Andrew E. Arai, George Pantely, William J. Thoma, Cheryl G. Anselone, J. David Bristow

    Research output: Contribution to journalArticle

    20 Citations (Scopus)

    Abstract

    Difficulties in studying myocardial metabolism with adequate time resolution have led to contradictory conclusions regarding the mechanisms causing contractile abnormalities during the early stages of ischemia. In acutely instrumented swine, we investigated whether abnormalities in subendocardial ATP, phosphocreatine, or lactate content develop rapidly enough during the first few heart beats after onset of partial myocardial ischemia to contribute to contractile failure. Within the first 15 beats of a 40-50% reduction in left anterior descending coronary artery blood flow, regional myocardial function was significantly reduced but continuing to deteriorate. Rapidly frozen transmural left ventricular biopsies obtained on the 15th heart beat (±1.5 beats) after the onset of ischemia revealed significant decrements in subendocardial phosphocreatine and ATP levels to 77% (p

    Original languageEnglish (US)
    Pages (from-to)1137-1145
    Number of pages9
    JournalCirculation Research
    Volume70
    Issue number6
    StatePublished - 1990

    Fingerprint

    Phosphocreatine
    Energy Metabolism
    Myocardial Ischemia
    Ischemia
    Adenosine Triphosphate
    Regional Blood Flow
    Lactic Acid
    Coronary Vessels
    Swine
    Biopsy

    Keywords

    • ATP
    • Ischemia
    • Lactate
    • Myocardial metabolism
    • Phosphocreatine

    ASJC Scopus subject areas

    • Physiology
    • Cardiology and Cardiovascular Medicine

    Cite this

    Arai, A. E., Pantely, G., Thoma, W. J., Anselone, C. G., & Bristow, J. D. (1990). Energy metabolism and contractile function after 15 beats of moderate myocardial ischemia. Circulation Research, 70(6), 1137-1145.

    Energy metabolism and contractile function after 15 beats of moderate myocardial ischemia. / Arai, Andrew E.; Pantely, George; Thoma, William J.; Anselone, Cheryl G.; Bristow, J. David.

    In: Circulation Research, Vol. 70, No. 6, 1990, p. 1137-1145.

    Research output: Contribution to journalArticle

    Arai, AE, Pantely, G, Thoma, WJ, Anselone, CG & Bristow, JD 1990, 'Energy metabolism and contractile function after 15 beats of moderate myocardial ischemia', Circulation Research, vol. 70, no. 6, pp. 1137-1145.
    Arai AE, Pantely G, Thoma WJ, Anselone CG, Bristow JD. Energy metabolism and contractile function after 15 beats of moderate myocardial ischemia. Circulation Research. 1990;70(6):1137-1145.
    Arai, Andrew E. ; Pantely, George ; Thoma, William J. ; Anselone, Cheryl G. ; Bristow, J. David. / Energy metabolism and contractile function after 15 beats of moderate myocardial ischemia. In: Circulation Research. 1990 ; Vol. 70, No. 6. pp. 1137-1145.
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