Endothelin-1 does not mediate acute hypoxic pulmonary vasoconstriction in the intact newborn lamb

J. Wong, Paula Vanderford, J. W. Winters, R. Chang, S. J. Soifer, J. R. Fineman

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The mechanisms by which acute alveolar hypoxia induces pulmonary vasoconstriction remain unclear. Previous studies suggest that hypoxia- induced vasoconstriction is endothelium-dependent and is associated with the release of endothelin-1 (ET-1), a potent vasoactive paracrine hormone produced by vascular endothelial cells. The vasoconstrictive effects of ET-1 are likely to be mediated by ET(A) receptors located on vascular smooth- muscle cells. BQ-123 is a selective ET(A) receptor antagonist. To determine the role of ET-1 and ET(A) receptors on resting tone and hypoxic pulmonary vasoconstriction, we studied the effects of ET-1 and BQ-123 at rest and during hypoxia-induced pulmonary vasoconstriction in 12 intact newborn lambs (

Original languageEnglish (US)
JournalJournal of Cardiovascular Pharmacology
Volume22
Issue numberSUPPL. 8
StatePublished - 1993
Externally publishedYes

Fingerprint

Endothelin-1
Vasoconstriction
Lung
Vascular Smooth Muscle
Smooth Muscle Myocytes
Endothelium
Endothelial Cells
Hormones
Hypoxia
cyclo(Trp-Asp-Pro-Val-Leu)

Keywords

  • Endothelin receptors
  • Endothelin-1
  • Pulmonary vasoconstriction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology

Cite this

Endothelin-1 does not mediate acute hypoxic pulmonary vasoconstriction in the intact newborn lamb. / Wong, J.; Vanderford, Paula; Winters, J. W.; Chang, R.; Soifer, S. J.; Fineman, J. R.

In: Journal of Cardiovascular Pharmacology, Vol. 22, No. SUPPL. 8, 1993.

Research output: Contribution to journalArticle

Wong, J. ; Vanderford, Paula ; Winters, J. W. ; Chang, R. ; Soifer, S. J. ; Fineman, J. R. / Endothelin-1 does not mediate acute hypoxic pulmonary vasoconstriction in the intact newborn lamb. In: Journal of Cardiovascular Pharmacology. 1993 ; Vol. 22, No. SUPPL. 8.
@article{093b39dbd2de42008d12351d2a01d2c2,
title = "Endothelin-1 does not mediate acute hypoxic pulmonary vasoconstriction in the intact newborn lamb",
abstract = "The mechanisms by which acute alveolar hypoxia induces pulmonary vasoconstriction remain unclear. Previous studies suggest that hypoxia- induced vasoconstriction is endothelium-dependent and is associated with the release of endothelin-1 (ET-1), a potent vasoactive paracrine hormone produced by vascular endothelial cells. The vasoconstrictive effects of ET-1 are likely to be mediated by ET(A) receptors located on vascular smooth- muscle cells. BQ-123 is a selective ET(A) receptor antagonist. To determine the role of ET-1 and ET(A) receptors on resting tone and hypoxic pulmonary vasoconstriction, we studied the effects of ET-1 and BQ-123 at rest and during hypoxia-induced pulmonary vasoconstriction in 12 intact newborn lambs (",
keywords = "Endothelin receptors, Endothelin-1, Pulmonary vasoconstriction",
author = "J. Wong and Paula Vanderford and Winters, {J. W.} and R. Chang and Soifer, {S. J.} and Fineman, {J. R.}",
year = "1993",
language = "English (US)",
volume = "22",
journal = "Journal of Cardiovascular Pharmacology",
issn = "0160-2446",
publisher = "Lippincott Williams and Wilkins",
number = "SUPPL. 8",

}

TY - JOUR

T1 - Endothelin-1 does not mediate acute hypoxic pulmonary vasoconstriction in the intact newborn lamb

AU - Wong, J.

AU - Vanderford, Paula

AU - Winters, J. W.

AU - Chang, R.

AU - Soifer, S. J.

AU - Fineman, J. R.

PY - 1993

Y1 - 1993

N2 - The mechanisms by which acute alveolar hypoxia induces pulmonary vasoconstriction remain unclear. Previous studies suggest that hypoxia- induced vasoconstriction is endothelium-dependent and is associated with the release of endothelin-1 (ET-1), a potent vasoactive paracrine hormone produced by vascular endothelial cells. The vasoconstrictive effects of ET-1 are likely to be mediated by ET(A) receptors located on vascular smooth- muscle cells. BQ-123 is a selective ET(A) receptor antagonist. To determine the role of ET-1 and ET(A) receptors on resting tone and hypoxic pulmonary vasoconstriction, we studied the effects of ET-1 and BQ-123 at rest and during hypoxia-induced pulmonary vasoconstriction in 12 intact newborn lambs (

AB - The mechanisms by which acute alveolar hypoxia induces pulmonary vasoconstriction remain unclear. Previous studies suggest that hypoxia- induced vasoconstriction is endothelium-dependent and is associated with the release of endothelin-1 (ET-1), a potent vasoactive paracrine hormone produced by vascular endothelial cells. The vasoconstrictive effects of ET-1 are likely to be mediated by ET(A) receptors located on vascular smooth- muscle cells. BQ-123 is a selective ET(A) receptor antagonist. To determine the role of ET-1 and ET(A) receptors on resting tone and hypoxic pulmonary vasoconstriction, we studied the effects of ET-1 and BQ-123 at rest and during hypoxia-induced pulmonary vasoconstriction in 12 intact newborn lambs (

KW - Endothelin receptors

KW - Endothelin-1

KW - Pulmonary vasoconstriction

UR - http://www.scopus.com/inward/record.url?scp=0027723611&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027723611&partnerID=8YFLogxK

M3 - Article

VL - 22

JO - Journal of Cardiovascular Pharmacology

JF - Journal of Cardiovascular Pharmacology

SN - 0160-2446

IS - SUPPL. 8

ER -