Endocrinology: Follicular fluid insulin-like growth factor-I and insulin-like growth factor-II concentrations vary as a function of day 3 serum follicle stimulating hormone

David B. Seifer, Linda C. Giudice, Beth A. Dsupin, Ray V. Haning, Gary N. Frishman, Henry G. Burger

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

We determined follicular fluid concentrations of insulin-like growth factor (IGF)-I, IGF-II and inhibin as a function of day 3 serum follicle stimulating hormone (FSH) in 16 women undergoing follicular fluid aspiration in preparation for in-vitro fertilization and embryo transfer. Follicular fluid concentrations of IGF-I and IGF-II were significantly less in the 'low' FSH group as compared to the 'high' FSH group. The mean IGF-I concentration was 67.6 ng/ml [confidence intervals (CI) 51.6-92.5] in the 'low' FSH group compared to 87.1 ng/ml (CI 72.8-104.2; P < 0.025) in the 'high' FSH group. Mean IGF-II concentrations were 354.8 ng/ml (CI 297.8-422.9) in the 'low' FSH group compared to 489.8 ng/ml (CI 384.6-624.5; P < 0.05) in the 'high' FSH group. Follicular fluid inhibin concentrations did not differ between groups. These differences in follicular fluid IGF as a function of day 3 FSH may raise questions regarding the role growth factors play in the physiological processes of the ageing follicle.

Original languageEnglish (US)
Pages (from-to)804-806
Number of pages3
JournalHuman Reproduction
Volume10
Issue number4
DOIs
StatePublished - Apr 1995

Keywords

  • Follicular fluid
  • Growth factors
  • Ovarian reserve

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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