Abstract
Neural encoding of sensory stimuli is typically studied by averaging neural signals across repetitions of the same stimulus. However, recent work has suggested that the variance of neural activity across repeated trials can also depend on sensory inputs. Here we characterize how intertrial variance of the local field potential (LFP) in primary auditory cortex of awake ferrets is affected by continuous natural sound stimuli. We find that natural sounds often suppress the intertrial variance of low-frequency LFP (<16 Hz). However, the amount of the variance reduction is not significantly correlated with the amplitude of the mean response at the same recording site. Moreover, the variance changes occur with longer latency than the mean response. Although the dynamics of the mean response and intertrial variance differ, spectro-temporal receptive field analysis reveals that changes in LFP variance have frequency tuning similar to multiunit activity at the same recording site, suggesting a local origin for changes in LFP variance. In summary, the spectral tuning of LFP intertrial variance and the absence of a correlation with the amplitude of the mean evoked LFP suggest substantial heterogeneity in the interaction between spontaneous and stimulus-driven activity across local neural populations in auditory cortex.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2389-2398 |
| Number of pages | 10 |
| Journal | Journal of Neurophysiology |
| Volume | 115 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 1 2016 |
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Keywords
- Auditory cortex
- Local field potential
- Response variance
- Spectrotemporal receptive field
- Speech
ASJC Scopus subject areas
- Neuroscience(all)
- Physiology
- Medicine(all)
Cite this
Encoding of natural sounds by variance of the cortical local field potential. / Ding, Nai; Simon, Jonathan Z.; Shamma, Shihab A.; David, Stephen.
In: Journal of Neurophysiology, Vol. 115, No. 5, 01.05.2016, p. 2389-2398.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Encoding of natural sounds by variance of the cortical local field potential
AU - Ding, Nai
AU - Simon, Jonathan Z.
AU - Shamma, Shihab A.
AU - David, Stephen
PY - 2016/5/1
Y1 - 2016/5/1
N2 - Neural encoding of sensory stimuli is typically studied by averaging neural signals across repetitions of the same stimulus. However, recent work has suggested that the variance of neural activity across repeated trials can also depend on sensory inputs. Here we characterize how intertrial variance of the local field potential (LFP) in primary auditory cortex of awake ferrets is affected by continuous natural sound stimuli. We find that natural sounds often suppress the intertrial variance of low-frequency LFP (<16 Hz). However, the amount of the variance reduction is not significantly correlated with the amplitude of the mean response at the same recording site. Moreover, the variance changes occur with longer latency than the mean response. Although the dynamics of the mean response and intertrial variance differ, spectro-temporal receptive field analysis reveals that changes in LFP variance have frequency tuning similar to multiunit activity at the same recording site, suggesting a local origin for changes in LFP variance. In summary, the spectral tuning of LFP intertrial variance and the absence of a correlation with the amplitude of the mean evoked LFP suggest substantial heterogeneity in the interaction between spontaneous and stimulus-driven activity across local neural populations in auditory cortex.
AB - Neural encoding of sensory stimuli is typically studied by averaging neural signals across repetitions of the same stimulus. However, recent work has suggested that the variance of neural activity across repeated trials can also depend on sensory inputs. Here we characterize how intertrial variance of the local field potential (LFP) in primary auditory cortex of awake ferrets is affected by continuous natural sound stimuli. We find that natural sounds often suppress the intertrial variance of low-frequency LFP (<16 Hz). However, the amount of the variance reduction is not significantly correlated with the amplitude of the mean response at the same recording site. Moreover, the variance changes occur with longer latency than the mean response. Although the dynamics of the mean response and intertrial variance differ, spectro-temporal receptive field analysis reveals that changes in LFP variance have frequency tuning similar to multiunit activity at the same recording site, suggesting a local origin for changes in LFP variance. In summary, the spectral tuning of LFP intertrial variance and the absence of a correlation with the amplitude of the mean evoked LFP suggest substantial heterogeneity in the interaction between spontaneous and stimulus-driven activity across local neural populations in auditory cortex.
KW - Auditory cortex
KW - Local field potential
KW - Response variance
KW - Spectrotemporal receptive field
KW - Speech
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U2 - 10.1152/jn.00652.2015
DO - 10.1152/jn.00652.2015
M3 - Article
C2 - 26912594
AN - SCOPUS:84984823944
VL - 115
SP - 2389
EP - 2398
JO - Journal of Neurophysiology
JF - Journal of Neurophysiology
SN - 0022-3077
IS - 5
ER -