Enantioseparation of the esters of α-N-acetyl amino acids by lipase in ionic liquid

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22 Scopus citations

Abstract

Chiral α-amino acids have been obtained via enzymatic resolution in ionic liquid medium. The acetyl esters of a series of amino acids were separated by enzyme porcine pancreas lipase (PPL) in an aqueous solution of N-ethyl pyridinium trifluoroacetate, [EtPy]+[CF3OO]-. A comparative study with organic solvent acetonitrile shows that the ionic liquids provide a better medium for enzymatic resolution.

Original languageEnglish (US)
Pages (from-to)S240-S242
JournalChirality
Volume17
Issue numberSUPPL.
DOIs
StatePublished - 2005
Externally publishedYes

Keywords

  • Amino acids
  • Enzymatic resolution
  • Ionic liquid
  • Lipases
  • N-ethyl pyridinium trifluoroacetate

ASJC Scopus subject areas

  • Analytical Chemistry
  • Catalysis
  • Pharmacology
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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