En face spectral domain optical coherence tomography analysis of lamellar macular holes

Michael F. Clamp, Geoff Wilkes, Laura S. Leis, H. Richard McDonald, Robert N. Johnson, J. Michael Jumper, Arthur D. Fu, Emmett T. Cunningham, Paul J. Stewart, Sara J. Haug, Brandon Lujan

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

PURPOSE: To analyze the anatomical characteristics of lamellar macular holes using cross-sectional and en face spectral domain optical coherence tomography. METHODS: Forty-two lamellar macular holes were retrospectively identified for analysis. The location, cross-sectional length, and area of lamellar holes were measured using B-scans and en face imaging. The presence of photoreceptor inner segment/outer segment disruption and the presence or absence of epiretinal membrane formation were recorded. RESULTS: Forty-two lamellar macular holes were identified. Intraretinal splitting occurred within the outer plexiform layer in 97.6% of eyes. The area of intraretinal splitting in lamellar holes did not correlate with visual acuity. Eyes with inner segment/outer segment disruption had significantly worse mean logMAR visual acuity (0.363 ± 0.169; Snellen = 20/46) than in eyes without inner segment/outer segment disruption (0.203 ± 0.124; Snellen = 20/32) (analysis of variance, P = 0.004). Epiretinal membrane was present in 34 of 42 eyes (81.0%). CONCLUSION: En face imaging allowed for consistent detection and quantification of intraretinal splitting within the outer plexiform layer in patients with lamellar macular holes, supporting the notion that an area of anatomical weakness exists within Henle's fiber layer, presumably at the synaptic connection of these fibers within the outer plexiform layer. However, the en face area of intraretinal splitting did not correlate with visual acuity, disruption of the inner segment/outer segment junction was associated with significantly worse visual acuity in patients with lamellar macular holes.

Original languageEnglish (US)
Pages (from-to)1360-1366
Number of pages7
JournalRetina
Volume34
Issue number7
DOIs
StatePublished - 2014
Externally publishedYes

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Retinal Perforations
Optical Coherence Tomography
Visual Acuity
Epiretinal Membrane
Analysis of Variance

Keywords

  • area
  • epiretinal membrane
  • Henle's fiber layer
  • intraretinal schisis
  • IS/OS disruption
  • outer plexiform layer
  • spectral domain optical coherence tomography

ASJC Scopus subject areas

  • Ophthalmology
  • Medicine(all)

Cite this

Clamp, M. F., Wilkes, G., Leis, L. S., McDonald, H. R., Johnson, R. N., Jumper, J. M., ... Lujan, B. (2014). En face spectral domain optical coherence tomography analysis of lamellar macular holes. Retina, 34(7), 1360-1366. https://doi.org/10.1097/IAE.0000000000000115

En face spectral domain optical coherence tomography analysis of lamellar macular holes. / Clamp, Michael F.; Wilkes, Geoff; Leis, Laura S.; McDonald, H. Richard; Johnson, Robert N.; Jumper, J. Michael; Fu, Arthur D.; Cunningham, Emmett T.; Stewart, Paul J.; Haug, Sara J.; Lujan, Brandon.

In: Retina, Vol. 34, No. 7, 2014, p. 1360-1366.

Research output: Contribution to journalArticle

Clamp, MF, Wilkes, G, Leis, LS, McDonald, HR, Johnson, RN, Jumper, JM, Fu, AD, Cunningham, ET, Stewart, PJ, Haug, SJ & Lujan, B 2014, 'En face spectral domain optical coherence tomography analysis of lamellar macular holes', Retina, vol. 34, no. 7, pp. 1360-1366. https://doi.org/10.1097/IAE.0000000000000115
Clamp MF, Wilkes G, Leis LS, McDonald HR, Johnson RN, Jumper JM et al. En face spectral domain optical coherence tomography analysis of lamellar macular holes. Retina. 2014;34(7):1360-1366. https://doi.org/10.1097/IAE.0000000000000115
Clamp, Michael F. ; Wilkes, Geoff ; Leis, Laura S. ; McDonald, H. Richard ; Johnson, Robert N. ; Jumper, J. Michael ; Fu, Arthur D. ; Cunningham, Emmett T. ; Stewart, Paul J. ; Haug, Sara J. ; Lujan, Brandon. / En face spectral domain optical coherence tomography analysis of lamellar macular holes. In: Retina. 2014 ; Vol. 34, No. 7. pp. 1360-1366.
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abstract = "PURPOSE: To analyze the anatomical characteristics of lamellar macular holes using cross-sectional and en face spectral domain optical coherence tomography. METHODS: Forty-two lamellar macular holes were retrospectively identified for analysis. The location, cross-sectional length, and area of lamellar holes were measured using B-scans and en face imaging. The presence of photoreceptor inner segment/outer segment disruption and the presence or absence of epiretinal membrane formation were recorded. RESULTS: Forty-two lamellar macular holes were identified. Intraretinal splitting occurred within the outer plexiform layer in 97.6{\%} of eyes. The area of intraretinal splitting in lamellar holes did not correlate with visual acuity. Eyes with inner segment/outer segment disruption had significantly worse mean logMAR visual acuity (0.363 ± 0.169; Snellen = 20/46) than in eyes without inner segment/outer segment disruption (0.203 ± 0.124; Snellen = 20/32) (analysis of variance, P = 0.004). Epiretinal membrane was present in 34 of 42 eyes (81.0{\%}). CONCLUSION: En face imaging allowed for consistent detection and quantification of intraretinal splitting within the outer plexiform layer in patients with lamellar macular holes, supporting the notion that an area of anatomical weakness exists within Henle's fiber layer, presumably at the synaptic connection of these fibers within the outer plexiform layer. However, the en face area of intraretinal splitting did not correlate with visual acuity, disruption of the inner segment/outer segment junction was associated with significantly worse visual acuity in patients with lamellar macular holes.",
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AU - Clamp, Michael F.

AU - Wilkes, Geoff

AU - Leis, Laura S.

AU - McDonald, H. Richard

AU - Johnson, Robert N.

AU - Jumper, J. Michael

AU - Fu, Arthur D.

AU - Cunningham, Emmett T.

AU - Stewart, Paul J.

AU - Haug, Sara J.

AU - Lujan, Brandon

PY - 2014

Y1 - 2014

N2 - PURPOSE: To analyze the anatomical characteristics of lamellar macular holes using cross-sectional and en face spectral domain optical coherence tomography. METHODS: Forty-two lamellar macular holes were retrospectively identified for analysis. The location, cross-sectional length, and area of lamellar holes were measured using B-scans and en face imaging. The presence of photoreceptor inner segment/outer segment disruption and the presence or absence of epiretinal membrane formation were recorded. RESULTS: Forty-two lamellar macular holes were identified. Intraretinal splitting occurred within the outer plexiform layer in 97.6% of eyes. The area of intraretinal splitting in lamellar holes did not correlate with visual acuity. Eyes with inner segment/outer segment disruption had significantly worse mean logMAR visual acuity (0.363 ± 0.169; Snellen = 20/46) than in eyes without inner segment/outer segment disruption (0.203 ± 0.124; Snellen = 20/32) (analysis of variance, P = 0.004). Epiretinal membrane was present in 34 of 42 eyes (81.0%). CONCLUSION: En face imaging allowed for consistent detection and quantification of intraretinal splitting within the outer plexiform layer in patients with lamellar macular holes, supporting the notion that an area of anatomical weakness exists within Henle's fiber layer, presumably at the synaptic connection of these fibers within the outer plexiform layer. However, the en face area of intraretinal splitting did not correlate with visual acuity, disruption of the inner segment/outer segment junction was associated with significantly worse visual acuity in patients with lamellar macular holes.

AB - PURPOSE: To analyze the anatomical characteristics of lamellar macular holes using cross-sectional and en face spectral domain optical coherence tomography. METHODS: Forty-two lamellar macular holes were retrospectively identified for analysis. The location, cross-sectional length, and area of lamellar holes were measured using B-scans and en face imaging. The presence of photoreceptor inner segment/outer segment disruption and the presence or absence of epiretinal membrane formation were recorded. RESULTS: Forty-two lamellar macular holes were identified. Intraretinal splitting occurred within the outer plexiform layer in 97.6% of eyes. The area of intraretinal splitting in lamellar holes did not correlate with visual acuity. Eyes with inner segment/outer segment disruption had significantly worse mean logMAR visual acuity (0.363 ± 0.169; Snellen = 20/46) than in eyes without inner segment/outer segment disruption (0.203 ± 0.124; Snellen = 20/32) (analysis of variance, P = 0.004). Epiretinal membrane was present in 34 of 42 eyes (81.0%). CONCLUSION: En face imaging allowed for consistent detection and quantification of intraretinal splitting within the outer plexiform layer in patients with lamellar macular holes, supporting the notion that an area of anatomical weakness exists within Henle's fiber layer, presumably at the synaptic connection of these fibers within the outer plexiform layer. However, the en face area of intraretinal splitting did not correlate with visual acuity, disruption of the inner segment/outer segment junction was associated with significantly worse visual acuity in patients with lamellar macular holes.

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KW - epiretinal membrane

KW - Henle's fiber layer

KW - intraretinal schisis

KW - IS/OS disruption

KW - outer plexiform layer

KW - spectral domain optical coherence tomography

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