Empirical estimates of bonferroni corrections for use in chromosome mapping studies with the BXD recombinant inbred strains

John Belknap

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Most chromosome mapping efforts with the BXD recombinant inbred (RI) strains involve comparisons between a trait of interest and each of a large number of marker loci for evidence of linkage. Such multiple tests or comparisons greatly increase the Type I error rate compared to the single-test situation. Perhaps the most direct way to obtain multiple-test error rates is to employ a Bonferroni correction, where the single-test alpha is multiplied by the number of independent (nonredundant) comparisons (k) to yield a multiple-test alpha that protects against even one fortuitous association with any of the markers. Several empirical estimates of k are discussed for the published BXD marker set of 142 mapped loci and the newer unpublished marker set (October 1991) comprised of 352 marker loci. Reasonable estimates of k appear to be roughly 40 and 65 for these two marker sets, respectively.

Original languageEnglish (US)
Pages (from-to)677-684
Number of pages8
JournalBehavior Genetics
Volume22
Issue number6
DOIs
StatePublished - Nov 1992

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Chromosome Mapping
chromosome mapping
chromosome
testing
loci
linkage (genetics)
marker
test
comparison

Keywords

  • BXD recombinant inbred strains
  • chromosome mapping

ASJC Scopus subject areas

  • Psychology(all)
  • Behavioral Neuroscience
  • Genetics(clinical)
  • Genetics

Cite this

Empirical estimates of bonferroni corrections for use in chromosome mapping studies with the BXD recombinant inbred strains. / Belknap, John.

In: Behavior Genetics, Vol. 22, No. 6, 11.1992, p. 677-684.

Research output: Contribution to journalArticle

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