Electron Beam Irradiated Corneal Versus Gamma-Irradiated Scleral Patch Graft Erosion Rates in Glaucoma Drainage Device Surgery

Ross M. Passo, Zachary B. Hoskins, Khoa D. Tran, Corrina Patzer, Lorna (Beth) Edmunds, John Morrison, Mansi Parikh, Hana Takusagawa, Shandiz Tehrani

Research output: Contribution to journalArticle

Abstract

Introduction: Patch graft erosion and implant exposure is a known complication of glaucoma drainage device (GDD) surgery. Recently, electron beam (e-beam) irradiated corneal tissue has become available; however, limited data exist on the rates of erosion for e-beam irradiated corneal grafts compared to traditional scleral grafts after GDD surgery. Methods: This retrospective study examines the records of 253 eyes from 225 adult subjects who underwent GDD surgery with either e-beam irradiated corneal or scleral grafts at the Casey Eye Institute by five surgeons between April 22, 2014 and October 11, 2017. Surgical procedures and the occurrence of graft erosion were determined using billing codes and verified by manual review of electronic health records. Results: The average age at the time of surgery was 61.3 ± 17.5 years (n = 200) and 60.8 ± 16.8 years (n = 53) for the e-beam irradiated cornea and sclera groups, respectively. The average follow-up time post-surgery was 416 ± 345 days and 495 ± 343 days for the e-beam irradiated cornea and sclera groups, respectively. There were no statistically significant differences in sex, age, follow-up time, and glaucoma diagnosis between the groups; however, the e-beam irradiated cornea group was statistically more likely to have an Ahmed implant as compared to the sclera group. No erosion events were noted in either group. Conclusion: e-Beam irradiated corneal grafts were used 3.8 times more frequently relative to scleral grafts, yet there were no cases of graft erosion in either group during the follow-up period.

Original languageEnglish (US)
Pages (from-to)421-426
Number of pages6
JournalOphthalmology and Therapy
Volume8
Issue number3
DOIs
StatePublished - Sep 1 2019

Fingerprint

Glaucoma
Drainage
Electrons
Transplants
Equipment and Supplies
Sclera
Cornea
Electronic Health Records
Sex Characteristics
Retrospective Studies

Keywords

  • Corneal patch graft
  • Glaucoma drainage device (GDD)
  • Graft erosion
  • Scleral patch graft
  • Tube exposure

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Electron Beam Irradiated Corneal Versus Gamma-Irradiated Scleral Patch Graft Erosion Rates in Glaucoma Drainage Device Surgery. / Passo, Ross M.; Hoskins, Zachary B.; Tran, Khoa D.; Patzer, Corrina; Edmunds, Lorna (Beth); Morrison, John; Parikh, Mansi; Takusagawa, Hana; Tehrani, Shandiz.

In: Ophthalmology and Therapy, Vol. 8, No. 3, 01.09.2019, p. 421-426.

Research output: Contribution to journalArticle

Passo, Ross M. ; Hoskins, Zachary B. ; Tran, Khoa D. ; Patzer, Corrina ; Edmunds, Lorna (Beth) ; Morrison, John ; Parikh, Mansi ; Takusagawa, Hana ; Tehrani, Shandiz. / Electron Beam Irradiated Corneal Versus Gamma-Irradiated Scleral Patch Graft Erosion Rates in Glaucoma Drainage Device Surgery. In: Ophthalmology and Therapy. 2019 ; Vol. 8, No. 3. pp. 421-426.
@article{3af9e125666f40edbb84116d7b1a411a,
title = "Electron Beam Irradiated Corneal Versus Gamma-Irradiated Scleral Patch Graft Erosion Rates in Glaucoma Drainage Device Surgery",
abstract = "Introduction: Patch graft erosion and implant exposure is a known complication of glaucoma drainage device (GDD) surgery. Recently, electron beam (e-beam) irradiated corneal tissue has become available; however, limited data exist on the rates of erosion for e-beam irradiated corneal grafts compared to traditional scleral grafts after GDD surgery. Methods: This retrospective study examines the records of 253 eyes from 225 adult subjects who underwent GDD surgery with either e-beam irradiated corneal or scleral grafts at the Casey Eye Institute by five surgeons between April 22, 2014 and October 11, 2017. Surgical procedures and the occurrence of graft erosion were determined using billing codes and verified by manual review of electronic health records. Results: The average age at the time of surgery was 61.3 ± 17.5 years (n = 200) and 60.8 ± 16.8 years (n = 53) for the e-beam irradiated cornea and sclera groups, respectively. The average follow-up time post-surgery was 416 ± 345 days and 495 ± 343 days for the e-beam irradiated cornea and sclera groups, respectively. There were no statistically significant differences in sex, age, follow-up time, and glaucoma diagnosis between the groups; however, the e-beam irradiated cornea group was statistically more likely to have an Ahmed implant as compared to the sclera group. No erosion events were noted in either group. Conclusion: e-Beam irradiated corneal grafts were used 3.8 times more frequently relative to scleral grafts, yet there were no cases of graft erosion in either group during the follow-up period.",
keywords = "Corneal patch graft, Glaucoma drainage device (GDD), Graft erosion, Scleral patch graft, Tube exposure",
author = "Passo, {Ross M.} and Hoskins, {Zachary B.} and Tran, {Khoa D.} and Corrina Patzer and Edmunds, {Lorna (Beth)} and John Morrison and Mansi Parikh and Hana Takusagawa and Shandiz Tehrani",
year = "2019",
month = "9",
day = "1",
doi = "10.1007/s40123-019-0190-x",
language = "English (US)",
volume = "8",
pages = "421--426",
journal = "Ophthalmology and Therapy",
issn = "2193-8245",
publisher = "Springer London",
number = "3",

}

TY - JOUR

T1 - Electron Beam Irradiated Corneal Versus Gamma-Irradiated Scleral Patch Graft Erosion Rates in Glaucoma Drainage Device Surgery

AU - Passo, Ross M.

AU - Hoskins, Zachary B.

AU - Tran, Khoa D.

AU - Patzer, Corrina

AU - Edmunds, Lorna (Beth)

AU - Morrison, John

AU - Parikh, Mansi

AU - Takusagawa, Hana

AU - Tehrani, Shandiz

PY - 2019/9/1

Y1 - 2019/9/1

N2 - Introduction: Patch graft erosion and implant exposure is a known complication of glaucoma drainage device (GDD) surgery. Recently, electron beam (e-beam) irradiated corneal tissue has become available; however, limited data exist on the rates of erosion for e-beam irradiated corneal grafts compared to traditional scleral grafts after GDD surgery. Methods: This retrospective study examines the records of 253 eyes from 225 adult subjects who underwent GDD surgery with either e-beam irradiated corneal or scleral grafts at the Casey Eye Institute by five surgeons between April 22, 2014 and October 11, 2017. Surgical procedures and the occurrence of graft erosion were determined using billing codes and verified by manual review of electronic health records. Results: The average age at the time of surgery was 61.3 ± 17.5 years (n = 200) and 60.8 ± 16.8 years (n = 53) for the e-beam irradiated cornea and sclera groups, respectively. The average follow-up time post-surgery was 416 ± 345 days and 495 ± 343 days for the e-beam irradiated cornea and sclera groups, respectively. There were no statistically significant differences in sex, age, follow-up time, and glaucoma diagnosis between the groups; however, the e-beam irradiated cornea group was statistically more likely to have an Ahmed implant as compared to the sclera group. No erosion events were noted in either group. Conclusion: e-Beam irradiated corneal grafts were used 3.8 times more frequently relative to scleral grafts, yet there were no cases of graft erosion in either group during the follow-up period.

AB - Introduction: Patch graft erosion and implant exposure is a known complication of glaucoma drainage device (GDD) surgery. Recently, electron beam (e-beam) irradiated corneal tissue has become available; however, limited data exist on the rates of erosion for e-beam irradiated corneal grafts compared to traditional scleral grafts after GDD surgery. Methods: This retrospective study examines the records of 253 eyes from 225 adult subjects who underwent GDD surgery with either e-beam irradiated corneal or scleral grafts at the Casey Eye Institute by five surgeons between April 22, 2014 and October 11, 2017. Surgical procedures and the occurrence of graft erosion were determined using billing codes and verified by manual review of electronic health records. Results: The average age at the time of surgery was 61.3 ± 17.5 years (n = 200) and 60.8 ± 16.8 years (n = 53) for the e-beam irradiated cornea and sclera groups, respectively. The average follow-up time post-surgery was 416 ± 345 days and 495 ± 343 days for the e-beam irradiated cornea and sclera groups, respectively. There were no statistically significant differences in sex, age, follow-up time, and glaucoma diagnosis between the groups; however, the e-beam irradiated cornea group was statistically more likely to have an Ahmed implant as compared to the sclera group. No erosion events were noted in either group. Conclusion: e-Beam irradiated corneal grafts were used 3.8 times more frequently relative to scleral grafts, yet there were no cases of graft erosion in either group during the follow-up period.

KW - Corneal patch graft

KW - Glaucoma drainage device (GDD)

KW - Graft erosion

KW - Scleral patch graft

KW - Tube exposure

UR - http://www.scopus.com/inward/record.url?scp=85070724122&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85070724122&partnerID=8YFLogxK

U2 - 10.1007/s40123-019-0190-x

DO - 10.1007/s40123-019-0190-x

M3 - Article

VL - 8

SP - 421

EP - 426

JO - Ophthalmology and Therapy

JF - Ophthalmology and Therapy

SN - 2193-8245

IS - 3

ER -