Electroencephalographic effects of laudanosine in an animal model of epilepsy

Akio Tateishi, Mark Zornow, Mark S. Scheller, P. Claver Canfell

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We examined the effects of laudanosine, one of the principal metabolites of atracurium. on the electroencephalogram (EEG) in an animal model of induced epilepsy. Fourteen rabbits were anaesthetized with 4% halothane in oxygen, the trachea intubated and the lungs ventilated mechanically with 30% oxygen and 1% halothane in nitrogen. Animals were assigned randomly to receive either an in fusion of laudanosine (laudanosine group, n = 7) at a rate calculated to produce plasma concentrations similar to those found following the clinical use of atracurium, or an equal volume of normal saline (control group, n = 7). To induce an epileptogenic focus, gel-foam sponges soaked in a pH-adjusted 4% cefazolin solution were applied bilaterally to the parietal cortical surface. This resulted in the production of spike and burst EEG activity in all animals. However, scoring the frequency of the spikes and bursts revealed no significant differences between the laudanosine and control groups. We conclude that, in this animal model of epilepsy, no increased incidence of seizure activity was produced by mean plasma laudanosine concentrations as great as 0.8 μg ml-1. These results suggest that the routine use of atracurium is unlikely to provoke seizures, even in the presence of an epileptogenic focus.

Original languageEnglish (US)
Pages (from-to)548-552
Number of pages5
JournalBritish Journal of Anaesthesia
Volume62
Issue number5
DOIs
StatePublished - May 1989
Externally publishedYes

Fingerprint

Atracurium
Animal Model
Epilepsy
electroencephalography
epilepsy
halothane
seizures
Animals
Animal Models
Halothane
animal models
cefazolin
Burst
Spike
oxygen
trachea (vertebrates)
Oxygen
Plasma
foams
Electroencephalography

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Mathematics(all)
  • Statistics and Probability
  • Agricultural and Biological Sciences (miscellaneous)
  • Anesthesiology and Pain Medicine

Cite this

Electroencephalographic effects of laudanosine in an animal model of epilepsy. / Tateishi, Akio; Zornow, Mark; Scheller, Mark S.; Canfell, P. Claver.

In: British Journal of Anaesthesia, Vol. 62, No. 5, 05.1989, p. 548-552.

Research output: Contribution to journalArticle

Tateishi, Akio ; Zornow, Mark ; Scheller, Mark S. ; Canfell, P. Claver. / Electroencephalographic effects of laudanosine in an animal model of epilepsy. In: British Journal of Anaesthesia. 1989 ; Vol. 62, No. 5. pp. 548-552.
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