Efficacy, safety, and pharmacokinetics of candesartan cilexetil in hypertensive children aged 6 to 17 years

Howard Trachtman, James W. Hainer, Jennifer Sugg, Renli Teng, Jonathan M. Sorof, Jerilynn Radcliffe, Johan Vande Walle, Laszio Szabo, Tivadar Tulassay, Sandor Turi, Eva Marova, Alexander Jurko, Maria Horakova, Robert Achtel, John Barcia, Donald Batisky, Patrick Brophy, Bonita Falkner, Joseph Flynn, Randall JenkinsVijay Kusnoor, Kenneth Miller, Ana Paredes, Irene Restaino, Joseph Sherbotie, Gaston Zilleruelo, Myra Chiang, Farahnak Assadi, Shashi Nagaraj, Janice Sullivan, Michael Aigbe, Ronald Portman, Robert Mak, Michael Moritz, Robert Williams, Juan Kupferman, Naomi Neufeld, Jimmy Stewart, Coral Hanevold, Lydia Hazan, Jeffery Blummer, Melissa Henshaw, David Headley, Howard Trachtman, William Primack, L. Richard Feldenberg

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

This 4-week randomized, double blind, placebo-controlled study (N=240), 1-year open label trial (N=233), and single-dose pharmacokinetic study (N=22) evaluated candesartan cilexetil (3 doses) in hypertensive children aged 6 to 17years. Seventy-one percent were 12years of age or older, 71% were male, and 47% were black. Systolic (SBP)/diastolic (DBP) blood pressure declined 8.6/4.8-11.2/8.0mm Hg with candesartan and 3.7/ 1.8mm Hg with placebo (P.05). The response rate (SBP and DBP

Original languageEnglish (US)
Pages (from-to)743-750
Number of pages8
JournalJournal of Clinical Hypertension
Volume10
Issue number10
DOIs
StatePublished - Oct 2008
Externally publishedYes

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Pharmacokinetics
Placebos
Safety
Blood Pressure
candesartan cilexetil
candesartan

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Trachtman, H., Hainer, J. W., Sugg, J., Teng, R., Sorof, J. M., Radcliffe, J., ... Feldenberg, L. R. (2008). Efficacy, safety, and pharmacokinetics of candesartan cilexetil in hypertensive children aged 6 to 17 years. Journal of Clinical Hypertension, 10(10), 743-750. https://doi.org/10.1111/j.1751-7176.2008.00022.x

Efficacy, safety, and pharmacokinetics of candesartan cilexetil in hypertensive children aged 6 to 17 years. / Trachtman, Howard; Hainer, James W.; Sugg, Jennifer; Teng, Renli; Sorof, Jonathan M.; Radcliffe, Jerilynn; Vande Walle, Johan; Szabo, Laszio; Tulassay, Tivadar; Turi, Sandor; Marova, Eva; Jurko, Alexander; Horakova, Maria; Achtel, Robert; Barcia, John; Batisky, Donald; Brophy, Patrick; Falkner, Bonita; Flynn, Joseph; Jenkins, Randall; Kusnoor, Vijay; Miller, Kenneth; Paredes, Ana; Restaino, Irene; Sherbotie, Joseph; Zilleruelo, Gaston; Chiang, Myra; Assadi, Farahnak; Nagaraj, Shashi; Sullivan, Janice; Aigbe, Michael; Portman, Ronald; Mak, Robert; Moritz, Michael; Williams, Robert; Kupferman, Juan; Neufeld, Naomi; Stewart, Jimmy; Hanevold, Coral; Hazan, Lydia; Blummer, Jeffery; Henshaw, Melissa; Headley, David; Trachtman, Howard; Primack, William; Feldenberg, L. Richard.

In: Journal of Clinical Hypertension, Vol. 10, No. 10, 10.2008, p. 743-750.

Research output: Contribution to journalArticle

Trachtman, H, Hainer, JW, Sugg, J, Teng, R, Sorof, JM, Radcliffe, J, Vande Walle, J, Szabo, L, Tulassay, T, Turi, S, Marova, E, Jurko, A, Horakova, M, Achtel, R, Barcia, J, Batisky, D, Brophy, P, Falkner, B, Flynn, J, Jenkins, R, Kusnoor, V, Miller, K, Paredes, A, Restaino, I, Sherbotie, J, Zilleruelo, G, Chiang, M, Assadi, F, Nagaraj, S, Sullivan, J, Aigbe, M, Portman, R, Mak, R, Moritz, M, Williams, R, Kupferman, J, Neufeld, N, Stewart, J, Hanevold, C, Hazan, L, Blummer, J, Henshaw, M, Headley, D, Trachtman, H, Primack, W & Feldenberg, LR 2008, 'Efficacy, safety, and pharmacokinetics of candesartan cilexetil in hypertensive children aged 6 to 17 years', Journal of Clinical Hypertension, vol. 10, no. 10, pp. 743-750. https://doi.org/10.1111/j.1751-7176.2008.00022.x
Trachtman, Howard ; Hainer, James W. ; Sugg, Jennifer ; Teng, Renli ; Sorof, Jonathan M. ; Radcliffe, Jerilynn ; Vande Walle, Johan ; Szabo, Laszio ; Tulassay, Tivadar ; Turi, Sandor ; Marova, Eva ; Jurko, Alexander ; Horakova, Maria ; Achtel, Robert ; Barcia, John ; Batisky, Donald ; Brophy, Patrick ; Falkner, Bonita ; Flynn, Joseph ; Jenkins, Randall ; Kusnoor, Vijay ; Miller, Kenneth ; Paredes, Ana ; Restaino, Irene ; Sherbotie, Joseph ; Zilleruelo, Gaston ; Chiang, Myra ; Assadi, Farahnak ; Nagaraj, Shashi ; Sullivan, Janice ; Aigbe, Michael ; Portman, Ronald ; Mak, Robert ; Moritz, Michael ; Williams, Robert ; Kupferman, Juan ; Neufeld, Naomi ; Stewart, Jimmy ; Hanevold, Coral ; Hazan, Lydia ; Blummer, Jeffery ; Henshaw, Melissa ; Headley, David ; Trachtman, Howard ; Primack, William ; Feldenberg, L. Richard. / Efficacy, safety, and pharmacokinetics of candesartan cilexetil in hypertensive children aged 6 to 17 years. In: Journal of Clinical Hypertension. 2008 ; Vol. 10, No. 10. pp. 743-750.
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