Abstract
This 4-week randomized, double blind, placebo-controlled study (N=240), 1-year open label trial (N=233), and single-dose pharmacokinetic study (N=22) evaluated candesartan cilexetil (3 doses) in hypertensive children aged 6 to 17years. Seventy-one percent were 12years of age or older, 71% were male, and 47% were black. Systolic (SBP)/diastolic (DBP) blood pressure declined 8.6/4.8-11.2/8.0mm Hg with candesartan and 3.7/ 1.8mm Hg with placebo (P.05). The response rate (SBP and DBP
| Original language | English (US) |
|---|---|
| Pages (from-to) | 743-750 |
| Number of pages | 8 |
| Journal | Journal of Clinical Hypertension |
| Volume | 10 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 2008 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Internal Medicine
- Cardiology and Cardiovascular Medicine
Cite this
Efficacy, safety, and pharmacokinetics of candesartan cilexetil in hypertensive children aged 6 to 17 years. / Trachtman, Howard; Hainer, James W.; Sugg, Jennifer; Teng, Renli; Sorof, Jonathan M.; Radcliffe, Jerilynn; Vande Walle, Johan; Szabo, Laszio; Tulassay, Tivadar; Turi, Sandor; Marova, Eva; Jurko, Alexander; Horakova, Maria; Achtel, Robert; Barcia, John; Batisky, Donald; Brophy, Patrick; Falkner, Bonita; Flynn, Joseph; Jenkins, Randall; Kusnoor, Vijay; Miller, Kenneth; Paredes, Ana; Restaino, Irene; Sherbotie, Joseph; Zilleruelo, Gaston; Chiang, Myra; Assadi, Farahnak; Nagaraj, Shashi; Sullivan, Janice; Aigbe, Michael; Portman, Ronald; Mak, Robert; Moritz, Michael; Williams, Robert; Kupferman, Juan; Neufeld, Naomi; Stewart, Jimmy; Hanevold, Coral; Hazan, Lydia; Blummer, Jeffery; Henshaw, Melissa; Headley, David; Trachtman, Howard; Primack, William; Feldenberg, L. Richard.
In: Journal of Clinical Hypertension, Vol. 10, No. 10, 10.2008, p. 743-750.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Efficacy, safety, and pharmacokinetics of candesartan cilexetil in hypertensive children aged 6 to 17 years
AU - Trachtman, Howard
AU - Hainer, James W.
AU - Sugg, Jennifer
AU - Teng, Renli
AU - Sorof, Jonathan M.
AU - Radcliffe, Jerilynn
AU - Vande Walle, Johan
AU - Szabo, Laszio
AU - Tulassay, Tivadar
AU - Turi, Sandor
AU - Marova, Eva
AU - Jurko, Alexander
AU - Horakova, Maria
AU - Achtel, Robert
AU - Barcia, John
AU - Batisky, Donald
AU - Brophy, Patrick
AU - Falkner, Bonita
AU - Flynn, Joseph
AU - Jenkins, Randall
AU - Kusnoor, Vijay
AU - Miller, Kenneth
AU - Paredes, Ana
AU - Restaino, Irene
AU - Sherbotie, Joseph
AU - Zilleruelo, Gaston
AU - Chiang, Myra
AU - Assadi, Farahnak
AU - Nagaraj, Shashi
AU - Sullivan, Janice
AU - Aigbe, Michael
AU - Portman, Ronald
AU - Mak, Robert
AU - Moritz, Michael
AU - Williams, Robert
AU - Kupferman, Juan
AU - Neufeld, Naomi
AU - Stewart, Jimmy
AU - Hanevold, Coral
AU - Hazan, Lydia
AU - Blummer, Jeffery
AU - Henshaw, Melissa
AU - Headley, David
AU - Trachtman, Howard
AU - Primack, William
AU - Feldenberg, L. Richard
PY - 2008/10
Y1 - 2008/10
N2 - This 4-week randomized, double blind, placebo-controlled study (N=240), 1-year open label trial (N=233), and single-dose pharmacokinetic study (N=22) evaluated candesartan cilexetil (3 doses) in hypertensive children aged 6 to 17years. Seventy-one percent were 12years of age or older, 71% were male, and 47% were black. Systolic (SBP)/diastolic (DBP) blood pressure declined 8.6/4.8-11.2/8.0mm Hg with candesartan and 3.7/ 1.8mm Hg with placebo (P.05). The response rate (SBP and DBP
AB - This 4-week randomized, double blind, placebo-controlled study (N=240), 1-year open label trial (N=233), and single-dose pharmacokinetic study (N=22) evaluated candesartan cilexetil (3 doses) in hypertensive children aged 6 to 17years. Seventy-one percent were 12years of age or older, 71% were male, and 47% were black. Systolic (SBP)/diastolic (DBP) blood pressure declined 8.6/4.8-11.2/8.0mm Hg with candesartan and 3.7/ 1.8mm Hg with placebo (P.05). The response rate (SBP and DBP
UR - http://www.scopus.com/inward/record.url?scp=58949094116&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=58949094116&partnerID=8YFLogxK
U2 - 10.1111/j.1751-7176.2008.00022.x
DO - 10.1111/j.1751-7176.2008.00022.x
M3 - Article
VL - 10
SP - 743
EP - 750
JO - Journal of Clinical Hypertension
JF - Journal of Clinical Hypertension
SN - 1524-6175
IS - 10
ER -